Cardiac ¹⁸F-dopamine positron emission tomography predicts the type of phenoconversion of pure autonomic failure

go back to reference Bradbury S, Eggleston C (1925) Postural hypotension: a report of three cases. Am Heart J 1:73–86CrossRef Bradbury S, Eggleston C (1925) Postural hypotension: a report of three cases. Am Heart J 1:73–86CrossRef

go back to reference Chia R, Sabir MS, Bandres-Ciga S, Saez-Atienzar S, Reynolds RH, Gustavsson E, Walton RL, Ahmed S, Viollet C, Ding J, Makarious MB, Diez-Fairen M, Portley MK, Shah Z, Abramzon Y, Hernandez DG, Blauwendraat C, Stone DJ, Eicher J, Parkkinen L, Ansorge O, Clark L, Honig LS, Marder K, Lemstra A, St George-Hyslop P, Londos E, Morgan K, Lashley T, Warner TT, Jaunmuktane Z, Galasko D, Santana I, Tienari PJ, Myllykangas L, Oinas M, Cairns NJ, Morris JC, Halliday GM, Van Deerlin VM, Trojanowski JQ, Grassano M, Calvo A, Mora G, Canosa A, Floris G, Bohannan RC, Brett F, Gan-Or Z, Geiger JT, Moore A, May P, Kruger R, Goldstein DS, Lopez G, Tayebi N, Sidransky E, American Genome C, Norcliffe-Kaufmann L, Palma JA, Kaufmann H, Shakkottai VG, Perkins M, Newell KL, Gasser T, Schulte C, Landi F, Salvi E, Cusi D, Masliah E, Kim RC, Caraway CA, Monuki ES, Brunetti M, Dawson TM, Rosenthal LS, Albert MS, Pletnikova O, Troncoso JC, Flanagan ME, Mao Q, Bigio EH, Rodriguez-Rodriguez E, Infante J, Lage C, Gonzalez-Aramburu I, Sanchez-Juan P, Ghetti B, Keith J, Black SE, Masellis M, Rogaeva E, Duyckaerts C, Brice A, Lesage S, Xiromerisiou G, Barrett MJ, Tilley BS, Gentleman S, Logroscino G et al (2021) Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nat Genet 53:294–303PubMedPubMedCentralCrossRef Chia R, Sabir MS, Bandres-Ciga S, Saez-Atienzar S, Reynolds RH, Gustavsson E, Walton RL, Ahmed S, Viollet C, Ding J, Makarious MB, Diez-Fairen M, Portley MK, Shah Z, Abramzon Y, Hernandez DG, Blauwendraat C, Stone DJ, Eicher J, Parkkinen L, Ansorge O, Clark L, Honig LS, Marder K, Lemstra A, St George-Hyslop P, Londos E, Morgan K, Lashley T, Warner TT, Jaunmuktane Z, Galasko D, Santana I, Tienari PJ, Myllykangas L, Oinas M, Cairns NJ, Morris JC, Halliday GM, Van Deerlin VM, Trojanowski JQ, Grassano M, Calvo A, Mora G, Canosa A, Floris G, Bohannan RC, Brett F, Gan-Or Z, Geiger JT, Moore A, May P, Kruger R, Goldstein DS, Lopez G, Tayebi N, Sidransky E, American Genome C, Norcliffe-Kaufmann L, Palma JA, Kaufmann H, Shakkottai VG, Perkins M, Newell KL, Gasser T, Schulte C, Landi F, Salvi E, Cusi D, Masliah E, Kim RC, Caraway CA, Monuki ES, Brunetti M, Dawson TM, Rosenthal LS, Albert MS, Pletnikova O, Troncoso JC, Flanagan ME, Mao Q, Bigio EH, Rodriguez-Rodriguez E, Infante J, Lage C, Gonzalez-Aramburu I, Sanchez-Juan P, Ghetti B, Keith J, Black SE, Masellis M, Rogaeva E, Duyckaerts C, Brice A, Lesage S, Xiromerisiou G, Barrett MJ, Tilley BS, Gentleman S, Logroscino G et al (2021) Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nat Genet 53:294–303PubMedPubMedCentralCrossRef

go back to reference Cook GA, Sullivan P, Holmes C, Goldstein DS (2014) Cardiac sympathetic denervation without lewy bodies in a case of multiple system atrophy. Parkinsonism Relat Disord 20:926–928PubMedPubMedCentralCrossRef Cook GA, Sullivan P, Holmes C, Goldstein DS (2014) Cardiac sympathetic denervation without lewy bodies in a case of multiple system atrophy. Parkinsonism Relat Disord 20:926–928PubMedPubMedCentralCrossRef

go back to reference Coon EA, Mandrekar JN, Berini SE, Benarroch EE, Sandroni P, Low PA, Singer W (2020) Predicting phenoconversion in pure autonomic failure. Neurology 95:e889–e897PubMedPubMedCentralCrossRef Coon EA, Mandrekar JN, Berini SE, Benarroch EE, Sandroni P, Low PA, Singer W (2020) Predicting phenoconversion in pure autonomic failure. Neurology 95:e889–e897PubMedPubMedCentralCrossRef

go back to reference de Natale ER, Wilson H, Politis M (2022) Predictors of RBD progression and conversion to synucleinopathies. Curr Neurol Neurosci Rep 22:93–104PubMedPubMedCentralCrossRef de Natale ER, Wilson H, Politis M (2022) Predictors of RBD progression and conversion to synucleinopathies. Curr Neurol Neurosci Rep 22:93–104PubMedPubMedCentralCrossRef

go back to reference Del Tredici K, Braak H (2013) Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson’s disease-related dementia. J Neurol Neurosurg Psychiatry 84:774–783PubMedCrossRef Del Tredici K, Braak H (2013) Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson’s disease-related dementia. J Neurol Neurosurg Psychiatry 84:774–783PubMedCrossRef

go back to reference Dickson DW (2012) Parkinson’s disease and parkinsonism: neuropathology. Cold Spring Harb Perspect Med 2:a009258 Dickson DW (2012) Parkinson’s disease and parkinsonism: neuropathology. Cold Spring Harb Perspect Med 2:a009258

go back to reference Donadio V (2019) Skin nerve alpha-synuclein deposits in Parkinson’s disease and other synucleinopathies: a review. Clin Auton Res 29:577–585PubMedCrossRef Donadio V (2019) Skin nerve alpha-synuclein deposits in Parkinson’s disease and other synucleinopathies: a review. Clin Auton Res 29:577–585PubMedCrossRef

go back to reference Donadio V, Incensi A, Rizzo G, Westermark GT, Devigili G, De Micco R, Tessitore A, Nyholm D, Parisini S, Nyman D, Tedeschi G, Eleopra R, Ingelsson M, Liguori R (2023) Phosphorylated alpha-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy. Brain 146:1065–1074PubMedCrossRef Donadio V, Incensi A, Rizzo G, Westermark GT, Devigili G, De Micco R, Tessitore A, Nyholm D, Parisini S, Nyman D, Tedeschi G, Eleopra R, Ingelsson M, Liguori R (2023) Phosphorylated alpha-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy. Brain 146:1065–1074PubMedCrossRef

go back to reference Doppler CEJ, Kinnerup MB, Brune C, Farrher E, Betts M, Fedorova TD, Schaldemose JL, Knudsen K, Ismail R, Seger AD, Hansen AK, Staer K, Fink GR, Brooks DJ, Nahimi A, Borghammer P, Sommerauer M (2021) Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease. Brain 144:2732–2744PubMedCrossRef Doppler CEJ, Kinnerup MB, Brune C, Farrher E, Betts M, Fedorova TD, Schaldemose JL, Knudsen K, Ismail R, Seger AD, Hansen AK, Staer K, Fink GR, Brooks DJ, Nahimi A, Borghammer P, Sommerauer M (2021) Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease. Brain 144:2732–2744PubMedCrossRef

go back to reference Freeman R (2014) Diabetic autonomic neuropathy. Handb Clin Neurol 126:63–79PubMedCrossRef Freeman R (2014) Diabetic autonomic neuropathy. Handb Clin Neurol 126:63–79PubMedCrossRef

go back to reference Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz I, Schondorff R, Stewart JM, van Dijk JG (2011) Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res 21:69–72PubMedCrossRef Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz I, Schondorff R, Stewart JM, van Dijk JG (2011) Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res 21:69–72PubMedCrossRef

go back to reference Giannini G, Calandra-Buonaura G, Asioli GM, Cecere A, Barletta G, Mignani F, Ratti S, Guaraldi P, Provini F, Cortelli P (2018) The natural history of idiopathic autonomic failure: the IAF-BO cohort study. Neurology 91:e1245–e1254PubMedCrossRef Giannini G, Calandra-Buonaura G, Asioli GM, Cecere A, Barletta G, Mignani F, Ratti S, Guaraldi P, Provini F, Cortelli P (2018) The natural history of idiopathic autonomic failure: the IAF-BO cohort study. Neurology 91:e1245–e1254PubMedCrossRef

go back to reference Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, Durr A, Fowler CJ, Kaufmann H, Klockgether T, Lees A, Poewe W, Quinn N, Revesz T, Robertson D, Sandroni P, Seppi K, Vidailhet M (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71:670–676PubMedPubMedCentralCrossRef Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, Durr A, Fowler CJ, Kaufmann H, Klockgether T, Lees A, Poewe W, Quinn N, Revesz T, Robertson D, Sandroni P, Seppi K, Vidailhet M (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71:670–676PubMedPubMedCentralCrossRef

go back to reference Goldstein DS (2006) Orthostatic hypotension as an early finding in Parkinson’s disease. Clin Auton Res 16:46–54PubMedCrossRef Goldstein DS (2006) Orthostatic hypotension as an early finding in Parkinson’s disease. Clin Auton Res 16:46–54PubMedCrossRef

go back to reference Goldstein DS, Holmes C, Bentho O, Sato T, Moak J, Sharabi Y, Imrich R, Conant S, Eldadah BA (2008) Biomarkers to detect central dopamine deficiency and distinguish Parkinson disease from multiple system atrophy. Parkinsonism Relat Disord 14:600–607PubMedPubMedCentralCrossRef Goldstein DS, Holmes C, Bentho O, Sato T, Moak J, Sharabi Y, Imrich R, Conant S, Eldadah BA (2008) Biomarkers to detect central dopamine deficiency and distinguish Parkinson disease from multiple system atrophy. Parkinsonism Relat Disord 14:600–607PubMedPubMedCentralCrossRef

go back to reference Goldstein DS, Holmes C, Cannon RO 3rd, Eisenhofer G, Kopin IJ (1997) Sympathetic cardioneuropathy in dysautonomias. N Engl J Med 336:696–702PubMedCrossRef Goldstein DS, Holmes C, Cannon RO 3rd, Eisenhofer G, Kopin IJ (1997) Sympathetic cardioneuropathy in dysautonomias. N Engl J Med 336:696–702PubMedCrossRef

go back to reference Goldstein DS, Holmes C, Dendi R, Li ST, Brentzel S, Vernino S (2002) Pandysautonomia associated with impaired ganglionic neurotransmission and circulating antibody to the neuronal nicotinic receptor. Clin Auton Res 12:281–285PubMedCrossRef Goldstein DS, Holmes C, Dendi R, Li ST, Brentzel S, Vernino S (2002) Pandysautonomia associated with impaired ganglionic neurotransmission and circulating antibody to the neuronal nicotinic receptor. Clin Auton Res 12:281–285PubMedCrossRef

go back to reference Goldstein DS, Holmes C, Li ST, Bruce S, Metman LV, Cannon RO 3rd (2000) Cardiac sympathetic denervation in Parkinson disease. Ann Intern Med 133:338–347PubMedCrossRef Goldstein DS, Holmes C, Li ST, Bruce S, Metman LV, Cannon RO 3rd (2000) Cardiac sympathetic denervation in Parkinson disease. Ann Intern Med 133:338–347PubMedCrossRef

go back to reference Goldstein DS, Holmes C, Lopez GJ, Wu T, Sharabi Y (2018) Cardiac sympathetic denervation predicts PD in at-risk individuals. Parkinsonism Relat Disord 52:90–93PubMedCrossRef Goldstein DS, Holmes C, Lopez GJ, Wu T, Sharabi Y (2018) Cardiac sympathetic denervation predicts PD in at-risk individuals. Parkinsonism Relat Disord 52:90–93PubMedCrossRef

go back to reference Goldstein DS, Holmes C, Lopez GJ, Wu T, Sharabi Y (2018) Cerebrospinal fluid biomarkers of central dopamine deficiency predict Parkinson’s disease. Parkinsonism Relat Disord 50:108–112PubMedPubMedCentralCrossRef Goldstein DS, Holmes C, Lopez GJ, Wu T, Sharabi Y (2018) Cerebrospinal fluid biomarkers of central dopamine deficiency predict Parkinson’s disease. Parkinsonism Relat Disord 50:108–112PubMedPubMedCentralCrossRef

go back to reference Goldstein DS, Holmes C, Sharabi Y (2012) Cerebrospinal fluid biomarkers of central catecholamine deficiency in Parkinson’s disease and other synucleinopathies. Brain 135:1900–1913PubMedPubMedCentralCrossRef Goldstein DS, Holmes C, Sharabi Y (2012) Cerebrospinal fluid biomarkers of central catecholamine deficiency in Parkinson’s disease and other synucleinopathies. Brain 135:1900–1913PubMedPubMedCentralCrossRef

go back to reference Goldstein DS, Holmes C, Sharabi Y, Brentzel S, Eisenhofer G (2003) Plasma levels of catechols and metanephrines in neurogenic orthostatic hypotension. Neurology 60:1327–1332PubMedCrossRef Goldstein DS, Holmes C, Sharabi Y, Brentzel S, Eisenhofer G (2003) Plasma levels of catechols and metanephrines in neurogenic orthostatic hypotension. Neurology 60:1327–1332PubMedCrossRef

go back to reference Goldstein DS, Holmes C, Sharabi Y, Wu T (2015) Survival in synucleinopathies: a prospective cohort study. Neurology 85:1554–1561PubMedPubMedCentralCrossRef Goldstein DS, Holmes C, Sharabi Y, Wu T (2015) Survival in synucleinopathies: a prospective cohort study. Neurology 85:1554–1561PubMedPubMedCentralCrossRef

go back to reference Goldstein DS, Holmes C, Sullivan P, Donadio V, Isonaka R, Zhong E, Pourier B, Vernino S, Kopin IJ, Sharabi Y (2017) Autoimmunity-associated autonomic failure with sympathetic denervation. Clin Auton Res 27:57–62PubMedCrossRef Goldstein DS, Holmes C, Sullivan P, Donadio V, Isonaka R, Zhong E, Pourier B, Vernino S, Kopin IJ, Sharabi Y (2017) Autoimmunity-associated autonomic failure with sympathetic denervation. Clin Auton Res 27:57–62PubMedCrossRef

go back to reference Goldstein DS, Sullivan P, Holmes C, Lamotte G, Lenka A, Sharabi Y (2021) Differential abnormalities of cerebrospinal fluid dopaminergic versus noradrenergic indices in synucleinopathies. J Neurochem 158:554–568PubMedPubMedCentralCrossRef Goldstein DS, Sullivan P, Holmes C, Lamotte G, Lenka A, Sharabi Y (2021) Differential abnormalities of cerebrospinal fluid dopaminergic versus noradrenergic indices in synucleinopathies. J Neurochem 158:554–568PubMedPubMedCentralCrossRef

go back to reference Goldstein DS, Tack C (2000) Non-invasive detection of sympathetic neurocirculatory failure. Clin Auton Res 10:285–291PubMedCrossRef Goldstein DS, Tack C (2000) Non-invasive detection of sympathetic neurocirculatory failure. Clin Auton Res 10:285–291PubMedCrossRef

go back to reference Holmes C, Eisenhofer G, Goldstein DS (1994) Improved assay for plasma dihydroxyphenylacetic acid and other catechols using high-performance liquid chromatography with electrochemical detection. J Chromatogr B Biomed Appl 653:131–138PubMedCrossRef Holmes C, Eisenhofer G, Goldstein DS (1994) Improved assay for plasma dihydroxyphenylacetic acid and other catechols using high-performance liquid chromatography with electrochemical detection. J Chromatogr B Biomed Appl 653:131–138PubMedCrossRef

go back to reference Horsager J, Knudsen K, Sommerauer M (2022) Clinical and imaging evidence of brain-first and body-first Parkinson’s disease. Neurobiol Dis 164:105626PubMedCrossRef Horsager J, Knudsen K, Sommerauer M (2022) Clinical and imaging evidence of brain-first and body-first Parkinson’s disease. Neurobiol Dis 164:105626PubMedCrossRef

go back to reference Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184PubMedPubMedCentralCrossRef Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181–184PubMedPubMedCentralCrossRef

go back to reference Isonaka R, Holmes C, Cook GA, Sullivan P, Sharabi Y, Goldstein DS (2017) Pure autonomic failure without synucleinopathy. Clin Auton Res 27:97–101PubMedCrossRef Isonaka R, Holmes C, Cook GA, Sullivan P, Sharabi Y, Goldstein DS (2017) Pure autonomic failure without synucleinopathy. Clin Auton Res 27:97–101PubMedCrossRef

go back to reference Isonaka R, Rosenberg AZ, Sullivan P, Corrales A, Holmes C, Sharabi Y, Goldstein DS (2019) Alpha-Synuclein deposition within sympathetic noradrenergic neurons is associated with myocardial noradrenergic deficiency in neurogenic orthostatic hypotension. Hypertension 73:910–918PubMedCrossRef Isonaka R, Rosenberg AZ, Sullivan P, Corrales A, Holmes C, Sharabi Y, Goldstein DS (2019) Alpha-Synuclein deposition within sympathetic noradrenergic neurons is associated with myocardial noradrenergic deficiency in neurogenic orthostatic hypotension. Hypertension 73:910–918PubMedCrossRef

go back to reference Jellinger KA (2003) Neuropathological spectrum of synucleinopathies. Mov Disord 18(Suppl 6):S2-12PubMedCrossRef Jellinger KA (2003) Neuropathological spectrum of synucleinopathies. Mov Disord 18(Suppl 6):S2-12PubMedCrossRef

go back to reference Kaufmann H (1996) Consensus statement on the definition of orthostatic hypotension, pure autonomic failure and multiple system atrophy. Clin Auton Res 6:125–126PubMedCrossRef Kaufmann H (1996) Consensus statement on the definition of orthostatic hypotension, pure autonomic failure and multiple system atrophy. Clin Auton Res 6:125–126PubMedCrossRef

go back to reference Kaufmann H, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Low PA, Singer W, Goldstein DS, Peltier AC, Shibao CA, Gibbons CH, Freeman R, Robertson D (2017) Natural history of pure autonomic failure: a United States prospective cohort. Ann Neurol 81:287–297PubMedPubMedCentralCrossRef Kaufmann H, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Low PA, Singer W, Goldstein DS, Peltier AC, Shibao CA, Gibbons CH, Freeman R, Robertson D (2017) Natural history of pure autonomic failure: a United States prospective cohort. Ann Neurol 81:287–297PubMedPubMedCentralCrossRef

go back to reference Lamotte G, Holmes C, Wu T, Goldstein DS (2019) Long-term trends in myocardial sympathetic innervation and function in synucleinopathies. Parkinsonism Relat Disord 67:27–33PubMedPubMedCentralCrossRef Lamotte G, Holmes C, Wu T, Goldstein DS (2019) Long-term trends in myocardial sympathetic innervation and function in synucleinopathies. Parkinsonism Relat Disord 67:27–33PubMedPubMedCentralCrossRef

go back to reference Lee PH, Yeo SH, Kim HJ, Youm HY (2006) Correlation between cardiac 123I-MIBG and odor identification in patients with Parkinson’s disease and multiple system atrophy. Mov Disord 21:1975–1977PubMedCrossRef Lee PH, Yeo SH, Kim HJ, Youm HY (2006) Correlation between cardiac 123I-MIBG and odor identification in patients with Parkinson’s disease and multiple system atrophy. Mov Disord 21:1975–1977PubMedCrossRef

go back to reference Lenka A, Lamotte G, Goldstein DS (2021) Cardiac (18) F-dopamine PET distinguishes PD with orthostatic hypotension from Parkinsonian MSA. Mov Disord Clin Pract 8:582–586PubMedPubMedCentralCrossRef Lenka A, Lamotte G, Goldstein DS (2021) Cardiac (18) F-dopamine PET distinguishes PD with orthostatic hypotension from Parkinsonian MSA. Mov Disord Clin Pract 8:582–586PubMedPubMedCentralCrossRef

go back to reference McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M, Consortium on DLB (2005) Diagnosis and management of dementia with lewy bodies: third report of the DLB consortium. Neurology 65:1863–1872PubMedCrossRef McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M, Consortium on DLB (2005) Diagnosis and management of dementia with lewy bodies: third report of the DLB consortium. Neurology 65:1863–1872PubMedCrossRef

go back to reference Muller A, Mungersdorf M, Reichmann H, Strehle G, Hummel T (2002) Olfactory function in Parkinsonian syndromes. J Clin Neurosci 9:521–524PubMedCrossRef Muller A, Mungersdorf M, Reichmann H, Strehle G, Hummel T (2002) Olfactory function in Parkinsonian syndromes. J Clin Neurosci 9:521–524PubMedCrossRef

go back to reference Nalls MA, Duran R, Lopez G, Kurzawa-Akanbi M, McKeith IG, Chinnery PF, Morris CM, Theuns J, Crosiers D, Cras P, Engelborghs S, De Deyn PP, Van Broeckhoven C, Mann DM, Snowden J, Pickering-Brown S, Halliwell N, Davidson Y, Gibbons L, Harris J, Sheerin UM, Bras J, Hardy J, Clark L, Marder K, Honig LS, Berg D, Maetzler W, Brockmann K, Gasser T, Novellino F, Quattrone A, Annesi G, De Marco EV, Rogaeva E, Masellis M, Black SE, Bilbao JM, Foroud T, Ghetti B, Nichols WC, Pankratz N, Halliday G, Lesage S, Klebe S, Durr A, Duyckaerts C, Brice A, Giasson BI, Trojanowski JQ, Hurtig HI, Tayebi N, Landazabal C, Knight MA, Keller M, Singleton AB, Wolfsberg TG, Sidransky E (2013) A multicenter study of glucocerebrosidase mutations in dementia with lewy bodies. JAMA Neurol. https://doi.org/10.1001/jamaneurol.2013.1925CrossRefPubMedPubMedCentral Nalls MA, Duran R, Lopez G, Kurzawa-Akanbi M, McKeith IG, Chinnery PF, Morris CM, Theuns J, Crosiers D, Cras P, Engelborghs S, De Deyn PP, Van Broeckhoven C, Mann DM, Snowden J, Pickering-Brown S, Halliwell N, Davidson Y, Gibbons L, Harris J, Sheerin UM, Bras J, Hardy J, Clark L, Marder K, Honig LS, Berg D, Maetzler W, Brockmann K, Gasser T, Novellino F, Quattrone A, Annesi G, De Marco EV, Rogaeva E, Masellis M, Black SE, Bilbao JM, Foroud T, Ghetti B, Nichols WC, Pankratz N, Halliday G, Lesage S, Klebe S, Durr A, Duyckaerts C, Brice A, Giasson BI, Trojanowski JQ, Hurtig HI, Tayebi N, Landazabal C, Knight MA, Keller M, Singleton AB, Wolfsberg TG, Sidransky E (2013) A multicenter study of glucocerebrosidase mutations in dementia with lewy bodies. JAMA Neurol. https://​doi.​org/​10.​1001/​jamaneurol.​2013.​1925CrossRefPubMedPubMedCentral

go back to reference Nylin G, Levander M (1948) Studies on the circulation with the aid of tagged erythrocytes in a case of orthostatic hypotension (asympathicotonic hypotension). Ann Intern Med 28:723–746PubMedCrossRef Nylin G, Levander M (1948) Studies on the circulation with the aid of tagged erythrocytes in a case of orthostatic hypotension (asympathicotonic hypotension). Ann Intern Med 28:723–746PubMedCrossRef

go back to reference Orimo S, Kanazawa T, Nakamura A, Uchihara T, Mori F, Kakita A, Wakabayashi K, Takahashi H (2007) Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy. Acta Neuropathol 113:81–86PubMedCrossRef Orimo S, Kanazawa T, Nakamura A, Uchihara T, Mori F, Kakita A, Wakabayashi K, Takahashi H (2007) Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy. Acta Neuropathol 113:81–86PubMedCrossRef

go back to reference Palma JA, Gonzalez-Duarte A, Kaufmann H (2019) Orthostatic hypotension in hereditary transthyretin amyloidosis: epidemiology, diagnosis and management. Clin Auton Res 29:33–44PubMedPubMedCentralCrossRef Palma JA, Gonzalez-Duarte A, Kaufmann H (2019) Orthostatic hypotension in hereditary transthyretin amyloidosis: epidemiology, diagnosis and management. Clin Auton Res 29:33–44PubMedPubMedCentralCrossRef

go back to reference Park DG, Kim JY, Kim MS, Kim MH, An YS, Chang J, Yoon JH (2023) Neurofilament light chain and cardiac MIBG uptake as predictors for phenoconversion in isolated REM sleep behavior disorder. J Neurol. https://doi.org/10.1007/s00415-023-11785-0CrossRefPubMed Park DG, Kim JY, Kim MS, Kim MH, An YS, Chang J, Yoon JH (2023) Neurofilament light chain and cardiac MIBG uptake as predictors for phenoconversion in isolated REM sleep behavior disorder. J Neurol. https://​doi.​org/​10.​1007/​s00415-023-11785-0CrossRefPubMed

go back to reference Senard JM, Arias A, Berlan M, Tran MA, Rascol A, Montastruc JL (1991) Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report. Eur J Clin Pharmacol 41:593–596PubMedCrossRef Senard JM, Arias A, Berlan M, Tran MA, Rascol A, Montastruc JL (1991) Pharmacological evidence of alpha 1- and alpha 2-adrenergic supersensitivity in orthostatic hypotension due to spinal cord injury: a case report. Eur J Clin Pharmacol 41:593–596PubMedCrossRef

go back to reference Singer W, Schmeichel AM, Shahnawaz M, Schmelzer JD, Sletten DM, Gehrking TL, Gehrking JA, Olson AD, Suarez MD, Misra PP, Soto C, Low PA (2021) Alpha-synuclein oligomers and neurofilament light chain predict phenoconversion of pure autonomic failure. Ann Neurol 89:1212–1220PubMedPubMedCentralCrossRef Singer W, Schmeichel AM, Shahnawaz M, Schmelzer JD, Sletten DM, Gehrking TL, Gehrking JA, Olson AD, Suarez MD, Misra PP, Soto C, Low PA (2021) Alpha-synuclein oligomers and neurofilament light chain predict phenoconversion of pure autonomic failure. Ann Neurol 89:1212–1220PubMedPubMedCentralCrossRef

go back to reference Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M (1998) Alpha-synuclein in filamentous inclusions of lewy bodies from Parkinson’s disease and dementia with lewy bodies. Proc Natl Acad Sci USA 95:6469–6473PubMedPubMedCentralCrossRef Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M (1998) Alpha-synuclein in filamentous inclusions of lewy bodies from Parkinson’s disease and dementia with lewy bodies. Proc Natl Acad Sci USA 95:6469–6473PubMedPubMedCentralCrossRef

go back to reference Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (1997) Alpha-synuclein in lewy bodies. Nature 388:839–840PubMedCrossRef Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (1997) Alpha-synuclein in lewy bodies. Nature 388:839–840PubMedCrossRef

go back to reference Wakabayashi K, Yoshimoto M, Tsuji S, Takahashi H (1998) Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 249:180–182PubMedCrossRef Wakabayashi K, Yoshimoto M, Tsuji S, Takahashi H (1998) Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 249:180–182PubMedCrossRef

go back to reference Wenning GK, Ben Shlomo Y, Magalhaes M, Daniel SE, Quinn NP (1994) Clinical features and natural history of multiple system atrophy. an analysis of 100 cases. Brain 117:835–845PubMedCrossRef Wenning GK, Ben Shlomo Y, Magalhaes M, Daniel SE, Quinn NP (1994) Clinical features and natural history of multiple system atrophy. an analysis of 100 cases. Brain 117:835–845PubMedCrossRef

go back to reference Ziegler MG, Lake CR, Kopin IJ (1977) The sympathetic-nervous-system defect in primary orthostatic hypotension. N Engl J Med 296:293–297PubMedCrossRef Ziegler MG, Lake CR, Kopin IJ (1977) The sympathetic-nervous-system defect in primary orthostatic hypotension. N Engl J Med 296:293–297PubMedCrossRef