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Open Access 01-12-2012 | Review

Parkinson’s disease and immune system: is the culprit LRRKing in the periphery?

Authors: Elisa Greggio, Laura Civiero, Marco Bisaglia, Luigi Bubacco

Published in: Journal of Neuroinflammation | Issue 1/2012

Abstract

Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain kinase/GTPase that has been recently linked to three pathological conditions: Parkinson’s disease; Crohn’s disease; and leprosy. Although LRRK2 physiological function is poorly understood, a potential role in inflammatory response is suggested by its high expression in immune cells and tissues, its up-regulation by interferon γ, and its function as negative regulator of the immune response transcription factor NFAT1. In this review we discuss the most recent findings regarding how LRRK2 could be a player in the inflammatory response and we propose a scenario where the detrimental effects mediated by Parkinson’s disease LRRK2 mutations may initiate in the periphery and extend to the central nervous system as a consequence of increased levels of pro-inflammatory factors permeable to the blood brain barrier.

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Title: Parkinson’s disease and immune system: is the culprit LRRKing in the periphery?
Authors: Elisa Greggio
Laura Civiero
Marco Bisaglia
Luigi Bubacco
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Journal of Neuroinflammation / Issue 1/2012
Electronic ISSN: 1742-2094
DOI: https://doi.org/10.1186/1742-2094-9-94

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Parkinson’s disease and immune system: is the culprit LRRKing in the periphery?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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