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International Archives of Occupational and Environmental Health

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Open Access 01-04-2021 | Original Article

Parental occupational exposure and congenital heart diseases in a Hungarian case–control study

Authors: Vince Fazekas-Pongor, Mónika Fekete, Melinda Csáky-Szunyogh, Károly Cseh, Melinda Pénzes

Published in: International Archives of Occupational and Environmental Health | Issue 3/2021

Abstract

Purpose

Our study aimed to explore the effect of parental occupational exposure to endocrine disrupting chemicals (EDCs) on the development of congenital heart diseases (CHDs) in the offspring, and to compare job-exposure matrix (JEM)-assessed and self-reported occupational exposures with each other.

Methods

Live-born infants born in 2007–2008 were selected from the population-based Hungarian Case–Control Surveillance of Congenital Abnormalities Study. 577 cases with any CHDs were compared to 1731 matched controls. Parental periconceptional occupational exposure to EDCs was assessed by a JEM and by questionnaire-based self-reporting of parents. Multivariate conditional logistic regression analyses were conducted to explore associations between parental occupational exposure to EDCs and the entire spectrum of CHDs and by CHD subtypes in the offspring. Kappa statistics were also performed to determine the consistency among JEM-assessed and self-reported occupational exposure of parents.

Results

JEM-assessed paternal exposure to polychlorinated organic substances, phthalates, biphenolic compounds, and solvents were significantly associated with the entire spectrum of CHDs. Ventricular septal defects were significantly associated with paternal self-reported exposure to pesticides, while atrial septal defects were significantly associated to paternal JEM-assessed phthalate exposure. Paternal solvent exposure was significantly associated with atrial septal defects and right ventricle outflow tract obstructions. JEM-assessed and self-reported exposures to pesticides, heavy metals, and solvents exhibited poor agreement for mothers and slight agreement for fathers.

Conclusion

Even though parental occupational exposure to EDCs seems to have a minor impact on the occurrence of CHDs, the results of biological and environmental monitoring should be taken into consideration as well.

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Title: Parental occupational exposure and congenital heart diseases in a Hungarian case–control study
Authors: Vince Fazekas-Pongor
Mónika Fekete
Melinda Csáky-Szunyogh
Károly Cseh
Melinda Pénzes
Publication date: 01-04-2021
Publisher: Springer Berlin Heidelberg
Published in: International Archives of Occupational and Environmental Health / Issue 3/2021
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-020-01589-4

At a glance: The STEP trials

Springer Medicine

Parental occupational exposure and congenital heart diseases in a Hungarian case–control study

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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