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26-07-2023 | Parathyroid Cancer | Case Report

Case presentation of the smallest non-functional parathyroid carcinoma and review of the literature

Authors: S. Ivaniš, M. Jovanović, D. Dunđerović, G. Zorić, B. Odalović, N. Slijepčević, K. Taušanović, B. Rovčanin, M. Buzejić, D. Vučen, B. Stepanović, J. Ilić, M. Parezanović, M. Marinković, M. Stojanović, A. Tošković, I. Mojsić, V. Živaljević

Published in: European Archives of Oto-Rhino-Laryngology | Issue 12/2023

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Abstract

Introduction

Non functional parathyroid carcinoma (PC) is one of the rarest malignant neoplasms. Due to the lack of symptoms and laboratory findings, it is mostly diagnosed in late AQ2 stages, when local invasion and dissemination are already present. However, our case is an exception, because it was detected in early stage, with no local invasion present. We present a case of the smallest non-functional PC yet reported and review of the literature.

Case presentation

A 47-year-old woman was admitted to outpatient Clinic where fine-needle aspiration biopsy (FNAB) of bilateral thyroid nodules (slide 1) and central neck mass (slide 2), which was suspected to be an enlarged lymphatic nodule or parathyroid gland was performed. Results came back as Bethesda I-colloid (slide 1), and Bethesda IV (slide 2), stating that it is hard to distinguish thyroid gland oxyphil lesions from parathyroid cells. Total thyroidectomy was performed as well as excision of the left central neck mass, without any involvement of surrounding structures. Pathological examination revealed bilateral thyroid follicular nodular disease, papillary microcarcinoma, and parathyroid carcinoma with vascular and capsular invasion, measuring 10 × 8 × 7 mm. The immunohistochemical profile included positive PTH, Chromogranin A, and negative TTF1.

Conclusion

Non-functional PC is usually diagnosed in advanced stages, already involving adjacent structures; however, this case presents a rare example. It is important not to exclude PC as a differential diagnosis in the absence of elevated Ca and PTH serum levels. Follow-up will be difficult, since there are no prognostic parameters to rely on.
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Metadata
Title
Case presentation of the smallest non-functional parathyroid carcinoma and review of the literature
Authors
S. Ivaniš
M. Jovanović
D. Dunđerović
G. Zorić
B. Odalović
N. Slijepčević
K. Taušanović
B. Rovčanin
M. Buzejić
D. Vučen
B. Stepanović
J. Ilić
M. Parezanović
M. Marinković
M. Stojanović
A. Tošković
I. Mojsić
V. Živaljević
Publication date
26-07-2023
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 12/2023
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-023-08137-z

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