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Published in: Updates in Surgery 3/2021

Open Access 01-06-2021 | Pancreatoduodenostomy | Review Article

State of the art of robotic pancreatoduodenectomy

Authors: Niccolò Napoli, Emanuele F. Kauffmann, Fabio Vistoli, Gabriella Amorese, Ugo Boggi

Published in: Updates in Surgery | Issue 3/2021

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Abstract

Current evidence shows that robotic pancreatoduodenectomy (RPD) is feasible with a safety profile equivalent to either open pancreatoduodenectomy (OPD) or laparoscopic pancreatoduodenectomy (LPD). However, major intraoperative bleeding can occur and emergency conversion to OPD may be required. RPD reduces the risk of emergency conversion when compared to LPD. The learning curve of RPD ranges from 20 to 40 procedures, but proficiency is reached only after 250 operations. Once proficiency is achieved, the results of RPD may be superior to those of OPD. As for now, RPD is at least equivalent to OPD and LPD with respect to incidence and severity of POPF, incidence and severity of post-operative complications, and post-operative mortality. A minimal annual number of 20 procedures per center is recommended. In pancreatic cancer (versus OPD), RPD is associated with similar rates of R0 resections, but higher number of examined lymph nodes, lower blood loss, and lower need of blood transfusions. Multivariable analysis shows that RPD could improve patient survival. Data from selected centers show that vein resection and reconstruction is feasible during RPD, but at the price of high conversion rates and frequent use of small tangential resections. The true Achilles heel of RPD is higher operative costs that limit wider implementation of the procedure and accumulation of a large experience at most single centers. In conclusion, when proficiency is achieved, RPD may be superior to OPD with respect to CR-POPF and oncologic outcomes. Achievement of proficiency requires commitment, dedication, and truly high volumes.
Literature
6.
go back to reference Giulianotti PC, Coratti A, Angelini M, Sbrana F, Cecconi S, Balestracci T, Caravaglios G (2003) Robotics in general surgery: personal experience in a large community hospital. Arch Surg 138:777–784CrossRefPubMed Giulianotti PC, Coratti A, Angelini M, Sbrana F, Cecconi S, Balestracci T, Caravaglios G (2003) Robotics in general surgery: personal experience in a large community hospital. Arch Surg 138:777–784CrossRefPubMed
8.
go back to reference Giulianotti PC, Mangano A, Bustos RE, Gheza F, Fernandes E, Masrur MA, Gangemi A, Bianco FM (2018) Operative technique in robotic pancreaticoduodenectomy (RPD) at University of Illinois at Chicago (UIC): 17 steps standardized technique : lessons learned since the first worldwide RPD performed in the year 2001. SurgEndosc 32:4329–4336. https://doi.org/10.1007/s00464-018-6228-7CrossRef Giulianotti PC, Mangano A, Bustos RE, Gheza F, Fernandes E, Masrur MA, Gangemi A, Bianco FM (2018) Operative technique in robotic pancreaticoduodenectomy (RPD) at University of Illinois at Chicago (UIC): 17 steps standardized technique : lessons learned since the first worldwide RPD performed in the year 2001. SurgEndosc 32:4329–4336. https://​doi.​org/​10.​1007/​s00464-018-6228-7CrossRef
18.
go back to reference Kauffmann EF, Napoli N, Menonna F, Iacopi S, Lombardo C, Bernardini J, Amorese G, CacciatoInsilla A, Funel N, Campani D, Cappelli C, Caramella D, Boggi U (2019) A propensity score-matched analysis of robotic versus open pancreatoduodenectomy for pancreatic cancer based on margin status. SurgEndosc 33:234–242. https://doi.org/10.1007/s00464-018-6301-2CrossRef Kauffmann EF, Napoli N, Menonna F, Iacopi S, Lombardo C, Bernardini J, Amorese G, CacciatoInsilla A, Funel N, Campani D, Cappelli C, Caramella D, Boggi U (2019) A propensity score-matched analysis of robotic versus open pancreatoduodenectomy for pancreatic cancer based on margin status. SurgEndosc 33:234–242. https://​doi.​org/​10.​1007/​s00464-018-6301-2CrossRef
19.
go back to reference van Hilst J, de Rooij T, Bosscha K, Brinkman DJ, van Dieren S, Dijkgraaf MG, Gerhards MF, de Hingh IH, Karsten TM, Lips DJ, Luyer MD, Busch OR, Festen S, Besselink MG; Dutch Pancreatic Cancer Group. Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2): a multicentre, patient-blinded, randomised controlled phase 2/3 trial. Lancet Gastroenterol Hepatol. 2019;4(3):199–207. doi: https://doi.org/10.1016/S2468-1253(19)30004-4. van Hilst J, de Rooij T, Bosscha K, Brinkman DJ, van Dieren S, Dijkgraaf MG, Gerhards MF, de Hingh IH, Karsten TM, Lips DJ, Luyer MD, Busch OR, Festen S, Besselink MG; Dutch Pancreatic Cancer Group. Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2): a multicentre, patient-blinded, randomised controlled phase 2/3 trial. Lancet Gastroenterol Hepatol. 2019;4(3):199–207. doi: https://​doi.​org/​10.​1016/​S2468-1253(19)30004-4.
20.
go back to reference Lof S, Vissers FL, Klompmaker S, Berti S, Boggi U, Coratti A, Dokmak S, Fara R, Festen S, D’Hondt M, Khatkov I, Lips D, Luyer M, Manzoni A, Rosso E, Saint-Marc O, Besselink MG, Abu Hilal M, European consortium on Minimally Invasive Pancreatic Surgery (E-MIPS), (2021) Risk of conversion to open surgery during robotic and laparoscopic pancreatoduodenectomy and effect on outcomes: international propensity score-matched comparison study. Br J Surg 108:80–87. https://doi.org/10.1093/bjs/znaa026CrossRefPubMed Lof S, Vissers FL, Klompmaker S, Berti S, Boggi U, Coratti A, Dokmak S, Fara R, Festen S, D’Hondt M, Khatkov I, Lips D, Luyer M, Manzoni A, Rosso E, Saint-Marc O, Besselink MG, Abu Hilal M, European consortium on Minimally Invasive Pancreatic Surgery (E-MIPS), (2021) Risk of conversion to open surgery during robotic and laparoscopic pancreatoduodenectomy and effect on outcomes: international propensity score-matched comparison study. Br J Surg 108:80–87. https://​doi.​org/​10.​1093/​bjs/​znaa026CrossRefPubMed
23.
go back to reference Kim H, Park SY, Park Y, Kwon J, Lee W, Song KB, Hwang DW, Kim SC, Lee JH (2020) Assessment of learning curve and oncologic feasibility of robotic pancreaticoduodenectomy: a propensity score-based comparison with open approach. J HepatobiliaryPancreatSci. https://doi.org/10.1002/jhbp.837CrossRef Kim H, Park SY, Park Y, Kwon J, Lee W, Song KB, Hwang DW, Kim SC, Lee JH (2020) Assessment of learning curve and oncologic feasibility of robotic pancreaticoduodenectomy: a propensity score-based comparison with open approach. J HepatobiliaryPancreatSci. https://​doi.​org/​10.​1002/​jhbp.​837CrossRef
32.
go back to reference Liu R, Zhang T, Zhao ZM, Tan XL, Zhao GD, Zhang X, Xu Y (2017) The surgical outcomes of robot-assisted laparoscopic pancreaticoduodenectomy versus laparoscopic pancreaticoduodenectomy for periampullary neoplasms: a comparative study of a single center. SurgEndosc 31:2380–2386 Liu R, Zhang T, Zhao ZM, Tan XL, Zhao GD, Zhang X, Xu Y (2017) The surgical outcomes of robot-assisted laparoscopic pancreaticoduodenectomy versus laparoscopic pancreaticoduodenectomy for periampullary neoplasms: a comparative study of a single center. SurgEndosc 31:2380–2386
36.
go back to reference Klompmaker S, van Hilst J, Wellner UF, Busch OR, Coratti A, D'Hondt M, Dokmak S, Festen S, Kerem M, Khatkov I, Lips DJ, Lombardo C, Luyer M, Manzoni A, Molenaar IQ, Rosso E, Saint-Marc O, Vansteenkiste F, Wittel UA, Bonsing B, Groot Koerkamp B, Abu Hilal M, Fuks D, Poves I, Keck T, Boggi U, Besselink MG; European consortium on Minimally Invasive Pancreatic Surgery (E-MIPS) (2020). Outcomes after minimally-invasive versus open pancreatoduodenectomy: a pan-european propensity score matched study. Ann Surg 271:356-363. doi: https://doi.org/10.1097/SLA.0000000000002850 Klompmaker S, van Hilst J, Wellner UF, Busch OR, Coratti A, D'Hondt M, Dokmak S, Festen S, Kerem M, Khatkov I, Lips DJ, Lombardo C, Luyer M, Manzoni A, Molenaar IQ, Rosso E, Saint-Marc O, Vansteenkiste F, Wittel UA, Bonsing B, Groot Koerkamp B, Abu Hilal M, Fuks D, Poves I, Keck T, Boggi U, Besselink MG; European consortium on Minimally Invasive Pancreatic Surgery (E-MIPS) (2020). Outcomes after minimally-invasive versus open pancreatoduodenectomy: a pan-european propensity score matched study. Ann Surg 271:356-363. doi: https://​doi.​org/​10.​1097/​SLA.​0000000000002850​
37.
go back to reference Mungroop TH, Klompmaker S, Wellner UF, Steyerberg EW, Coratti A, D'Hondt M, de Pastena M, Dokmak S, Khatov I, Saint-Marc O, Wittel U, Abu Hilal M, Fuks D, Poves I, Keck T, Boggi U, Besselink MG; European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS) (2021). Updated Alternative Fistula Risk Score (ua-FRS) to Include Minimally Invasive Pancreatoduodenectomy: Pan-European Validation. Ann Surg 273:334-340. doi: https://doi.org/10.1097/SLA.0000000000003234 Mungroop TH, Klompmaker S, Wellner UF, Steyerberg EW, Coratti A, D'Hondt M, de Pastena M, Dokmak S, Khatov I, Saint-Marc O, Wittel U, Abu Hilal M, Fuks D, Poves I, Keck T, Boggi U, Besselink MG; European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS) (2021). Updated Alternative Fistula Risk Score (ua-FRS) to Include Minimally Invasive Pancreatoduodenectomy: Pan-European Validation. Ann Surg 273:334-340. doi: https://​doi.​org/​10.​1097/​SLA.​0000000000003234​
39.
go back to reference Vining CC, Kuchta K, Schuitevoerder D, Paterakos P, Berger Y, Roggin KK, Talamonti MS, Hogg ME (2020) Risk factors for complications in patients undergoing pancreaticoduodenectomy: A NSQIP analysis with propensity score matching. J SurgOncol 122:183–194. https://doi.org/10.1002/jso.25942CrossRef Vining CC, Kuchta K, Schuitevoerder D, Paterakos P, Berger Y, Roggin KK, Talamonti MS, Hogg ME (2020) Risk factors for complications in patients undergoing pancreaticoduodenectomy: A NSQIP analysis with propensity score matching. J SurgOncol 122:183–194. https://​doi.​org/​10.​1002/​jso.​25942CrossRef
46.
go back to reference Nassour I, Winters SB, Hoehn R, Tohme S, Adam MA, Bartlett DL, Lee KK, Paniccia A, Zureikat AH (2020) Long-term oncologic outcomes of robotic and open pancreatectomy in a national cohort of pancreatic adenocarcinoma. J SurgOncol 122:234–242. https://doi.org/10.1002/jso.25958CrossRef Nassour I, Winters SB, Hoehn R, Tohme S, Adam MA, Bartlett DL, Lee KK, Paniccia A, Zureikat AH (2020) Long-term oncologic outcomes of robotic and open pancreatectomy in a national cohort of pancreatic adenocarcinoma. J SurgOncol 122:234–242. https://​doi.​org/​10.​1002/​jso.​25958CrossRef
51.
53.
go back to reference Bassi C, Marchegiani G, Giuliani T, Di Gioia A, Andrianello S, Zingaretti CC, Brentegani G, De Pastena M, Fontana M, Pea A, Paiella S, Malleo G, Tuveri M, Landoni L, Esposito A, Casetti L, Butturini G, Falconi M, Salvia R (2021) Pancreatoduodenectomy at the Verona Pancreas Institute: the evolution of indications, surgical techniques and outcomes: a retrospective analysis of 3000 consecutive cases. Ann Surg. https://doi.org/10.1097/SLA.0000000000004753CrossRefPubMed Bassi C, Marchegiani G, Giuliani T, Di Gioia A, Andrianello S, Zingaretti CC, Brentegani G, De Pastena M, Fontana M, Pea A, Paiella S, Malleo G, Tuveri M, Landoni L, Esposito A, Casetti L, Butturini G, Falconi M, Salvia R (2021) Pancreatoduodenectomy at the Verona Pancreas Institute: the evolution of indications, surgical techniques and outcomes: a retrospective analysis of 3000 consecutive cases. Ann Surg. https://​doi.​org/​10.​1097/​SLA.​0000000000004753​CrossRefPubMed
Metadata
Title
State of the art of robotic pancreatoduodenectomy
Authors
Niccolò Napoli
Emanuele F. Kauffmann
Fabio Vistoli
Gabriella Amorese
Ugo Boggi
Publication date
01-06-2021
Publisher
Springer International Publishing
Published in
Updates in Surgery / Issue 3/2021
Print ISSN: 2038-131X
Electronic ISSN: 2038-3312
DOI
https://doi.org/10.1007/s13304-021-01058-8

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