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Open Access 01-12-2021 | Pancreatic Cancer | Review

Current understanding of ferroptosis in the progression and treatment of pancreatic cancer

Authors: Shi Dong, Xin Li, Wenkai Jiang, Zhou Chen, Wence Zhou

Published in: Cancer Cell International | Issue 1/2021

Abstract

Pancreatic cancer is a highly malignant tumour of the digestive tract. Despite advances in treatment, its 5-year survival rate remains low, and its prognosis is the worst among all cancers; innovative therapeutic methods are needed. Ferroptosis is a form of regulatory cell death driven by iron accumulation and lipid peroxidation. Recent studies have found that ferroptosis plays an important role in the development and treatment response of tumours, particularly pancreatic cancer. This article reviews the current understanding of the mechanism of ferroptosis and ferroptosis-related treatment in pancreatic cancer.

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Title: Current understanding of ferroptosis in the progression and treatment of pancreatic cancer
Authors: Shi Dong
Xin Li
Wenkai Jiang
Zhou Chen
Wence Zhou
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Pancreatic Cancer
Pancreatic Cancer
Published in: Cancer Cell International / Issue 1/2021
Electronic ISSN: 1475-2867
DOI: https://doi.org/10.1186/s12935-021-02166-6

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