ASO Author Reflections: Impact of Myosteatosis and Creatinine-to-Cystatin C Ratio on Prognosis After Pancreatic Radical Surgery

Excerpt

Pancreatic cancer (PC) is a fatal malignancy with a 5-year survival rate of 6%;¹ surgery is the only curative therapy for PC. Conventional indexes are insufficient to accurately define the postoperative prognosis, such as TNM stage and CA19-9, therefore novel personalized prognostic indicators are urgently needed. In pathological conditions, patients are more susceptible to myosteatosis due to nutritional deficiencies, metabolic abnormalities, autoimmune derangement, and cachexia. Furthermore, myosteatosis is correlated with poor prognosis in some malignancies.^2,3 The creatinine-to-cystatin ratio (CCR) has been employed to estimate nutritional and metabolic status;⁴ however, the prognostic abilities of CCR and the combination of CCR and myosteatosis in patients with PC who underwent radical surgery remains unclear. …