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Published in: Pain and Therapy 1/2018

Open Access 01-06-2018 | Review

Pain in Platin-Induced Neuropathies: A Systematic Review and Meta-Analysis

Authors: Vasiliki Brozou, Athina Vadalouca, Panagiotis Zis

Published in: Pain and Therapy | Issue 1/2018

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Abstract

Introduction

Platin-induced peripheral neuropathy (PIPN) is a common cause of PN in cancer patients. The aim of this paper is to systematically review the current literature regarding PIPN, with a particular focus on epidemiological and clinical characteristics of painful PIPN, and to discuss relevant management strategies.

Methods

A systematic computer-based literature search was conducted on the PubMed database.

Results

This search strategy resulted in the identification of 353 articles. After the eligibility assessment, 282 articles were excluded. An additional 24 papers were identified by scanning the reference lists. In total, 95 papers met the inclusion criteria and were used for this review. The prevalence of neuropathic symptoms due to acute toxicity of oxaliplatin was estimated at 84.6%, whereas PN established after chemotherapy with platins was estimated at 74.9%. Specifically regarding pain, the reported prevalence of pain due to acute toxicity of oxaliplatin was estimated at 55.6%, whereas the reported prevalence of chronic peripheral neuropathic pain in PIPN was estimated at 49.2%.

Conclusion

Peripheral neuropathy is a common complication in patients receiving platins and can be particularly painful. There is significant heterogeneity among studies regarding the method for diagnosing peripheral neuropathy. Nerve conduction studies are the gold standard and should be performed in patients receiving platins and complaining of neuropathic symptoms post-treatment.
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Metadata
Title
Pain in Platin-Induced Neuropathies: A Systematic Review and Meta-Analysis
Authors
Vasiliki Brozou
Athina Vadalouca
Panagiotis Zis
Publication date
01-06-2018
Publisher
Springer Healthcare
Published in
Pain and Therapy / Issue 1/2018
Print ISSN: 2193-8237
Electronic ISSN: 2193-651X
DOI
https://doi.org/10.1007/s40122-017-0092-3

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