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Published in: Pediatric Radiology 4/2021

01-04-2021 | Minisymposium: Specialist Pediatric Radiology — Does it add value?

Paediatric gastrointestinal and hepatobiliary radiology: why do we need subspecialists, and what is new?

Authors: Tom A. Watson, Joy Barber, Helen Woodley

Published in: Pediatric Radiology | Issue 4/2021

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Abstract

We present the case for subspecialisation in paediatric gastrointestinal and hepato-pancreatico-biliary radiology. We frame the discussion around a number of questions: What is different about the paediatric patient and paediatric gastrointestinal system? What does the radiologist need to do differently? And finally, what can be translated from these subspecialty areas into everyday practice? We cover conditions that the sub-specialist might encounter, focusing on entities such as inflammatory bowel disease and hepatic vascular anomalies. We also highlight novel imaging techniques that are a focus of research in the subspecialties, including contrast-enhanced ultrasound, MRI motility, magnetisation transfer factor, and magnetic resonance elastography.
Literature
1.
go back to reference Cassel CK, Reuben DB (2011) Specialization, subspecialization, and subsubspecialization in internal medicine. N Engl J Med 364:1169–1173PubMedCrossRef Cassel CK, Reuben DB (2011) Specialization, subspecialization, and subsubspecialization in internal medicine. N Engl J Med 364:1169–1173PubMedCrossRef
2.
go back to reference Smith GG, Thrall JH, Pentecost MJ et al (2009) Subspecialization in radiology and radiation oncology. J Am Coll Radiol 6:147–159PubMedCrossRef Smith GG, Thrall JH, Pentecost MJ et al (2009) Subspecialization in radiology and radiation oncology. J Am Coll Radiol 6:147–159PubMedCrossRef
4.
go back to reference Yoon HM, Suh CH, Kim JR et al (2017) Diagnostic performance of sonographic features in patients with biliary atresia: a systematic review and meta-analysis. J Ultrasound Med 36:2027–2038CrossRef Yoon HM, Suh CH, Kim JR et al (2017) Diagnostic performance of sonographic features in patients with biliary atresia: a systematic review and meta-analysis. J Ultrasound Med 36:2027–2038CrossRef
5.
go back to reference Chavhan GB, Shelmerdine S, Jhaveri K, Babyn PS (2016) Liver MR imaging in children: current concepts and technique. Radiographics 36:1517–1532PubMedCrossRef Chavhan GB, Shelmerdine S, Jhaveri K, Babyn PS (2016) Liver MR imaging in children: current concepts and technique. Radiographics 36:1517–1532PubMedCrossRef
6.
go back to reference Nehra D, Goldstein AM (2011) Intestinal malrotation: varied clinical presentation from infancy through adulthood. Surgery 149:386–393PubMedCrossRef Nehra D, Goldstein AM (2011) Intestinal malrotation: varied clinical presentation from infancy through adulthood. Surgery 149:386–393PubMedCrossRef
7.
go back to reference Konuş ÖL, Özdemir A, Akkaya A et al (1998) Normal liver, spleen, and kidney dimensions in neonates, infants, and children: evaluation with sonography. AJR Am J Roentgenol 171:1693–1698PubMedCrossRef Konuş ÖL, Özdemir A, Akkaya A et al (1998) Normal liver, spleen, and kidney dimensions in neonates, infants, and children: evaluation with sonography. AJR Am J Roentgenol 171:1693–1698PubMedCrossRef
8.
go back to reference Hernanz-Schulman M, Ambrosino MM, Freeman PC, Quinn CB (1995) Common bile duct in children: sonographic dimensions. Radiology 195:193–195PubMedCrossRef Hernanz-Schulman M, Ambrosino MM, Freeman PC, Quinn CB (1995) Common bile duct in children: sonographic dimensions. Radiology 195:193–195PubMedCrossRef
9.
go back to reference Mesquita RD, Sousa M, Vilaverde F, Cardoso R (2018) Abernethy malformation: beware in cases of unexplained hepatic encephalopathy in adults — case report and review of the relevant literature. BJR Case Rep 4:20170054PubMed Mesquita RD, Sousa M, Vilaverde F, Cardoso R (2018) Abernethy malformation: beware in cases of unexplained hepatic encephalopathy in adults — case report and review of the relevant literature. BJR Case Rep 4:20170054PubMed
10.
go back to reference Chira RI, Calauz A, Manole S et al (2017) Unusual discovery after an examination for abdominal pain: Abernethy 1b malformation and liver adenomatosis. A case report. J Gastrointest Liver Dis 26:85–88 Chira RI, Calauz A, Manole S et al (2017) Unusual discovery after an examination for abdominal pain: Abernethy 1b malformation and liver adenomatosis. A case report. J Gastrointest Liver Dis 26:85–88
11.
go back to reference Sorkin T, Strautnieks S, Foskett P et al (2016) Multiple β-catenin mutations in hepatocellular lesions arising in Abernethy malformation. Hum Pathol 53:153–158PubMedCrossRef Sorkin T, Strautnieks S, Foskett P et al (2016) Multiple β-catenin mutations in hepatocellular lesions arising in Abernethy malformation. Hum Pathol 53:153–158PubMedCrossRef
12.
go back to reference Vade A, Lim-Dunham J, Iqbal N (2001) Imaging of the ductus venosus in neonates: from patency to closure. J Ultrasound Med 20:681–687PubMedCrossRef Vade A, Lim-Dunham J, Iqbal N (2001) Imaging of the ductus venosus in neonates: from patency to closure. J Ultrasound Med 20:681–687PubMedCrossRef
13.
go back to reference Chaturvedi A, Klionsky NB, Saul D (2018) Ultrasound with Doppler evaluation of congenital hepatic vascular shunts. Pediatr Radiol 48:1658–1671PubMedCrossRef Chaturvedi A, Klionsky NB, Saul D (2018) Ultrasound with Doppler evaluation of congenital hepatic vascular shunts. Pediatr Radiol 48:1658–1671PubMedCrossRef
14.
go back to reference Barber JL, Maclachlan J, Planche K et al (2017) There is good agreement between MR enterography and bowel ultrasound with regards to disease location and activity in paediatric inflammatory bowel disease. Clin Radiol 72:590–597PubMedCrossRef Barber JL, Maclachlan J, Planche K et al (2017) There is good agreement between MR enterography and bowel ultrasound with regards to disease location and activity in paediatric inflammatory bowel disease. Clin Radiol 72:590–597PubMedCrossRef
15.
go back to reference Miller CR (2007) Ultrasound in the assessment of the acute abdomen in children: its advantages and its limitations. Ultrasound Clin 2:525–540CrossRef Miller CR (2007) Ultrasound in the assessment of the acute abdomen in children: its advantages and its limitations. Ultrasound Clin 2:525–540CrossRef
16.
go back to reference Cornes JS (1965) Number, size, and distribution of Peyer’s patches in the human small intestine: Part I the development of Peyer’s patches. Gut 6:225–229 Cornes JS (1965) Number, size, and distribution of Peyer’s patches in the human small intestine: Part I the development of Peyer’s patches. Gut 6:225–229
17.
go back to reference Barber JL, Zambrano-Perez A, Olsen ØE et al (2018) Detecting inflammation in inflammatory bowel disease — how does ultrasound compare to magnetic resonance enterography using standardised scoring systems? Pediatr Radiol 48:843–851PubMedCrossRef Barber JL, Zambrano-Perez A, Olsen ØE et al (2018) Detecting inflammation in inflammatory bowel disease — how does ultrasound compare to magnetic resonance enterography using standardised scoring systems? Pediatr Radiol 48:843–851PubMedCrossRef
18.
go back to reference Chung EM, Lattin GE, Cube R et al (2011) From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation Part 2. Malignant tumors. Radiographics 31:483–507 Chung EM, Lattin GE, Cube R et al (2011) From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation Part 2. Malignant tumors. Radiographics 31:483–507
19.
go back to reference Chung EM, Cube R, Lewis RB, Conran RM (2010) From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation Part 1. Benign tumors. Radiographics 30:801–826 Chung EM, Cube R, Lewis RB, Conran RM (2010) From the archives of the AFIP: pediatric liver masses: radiologic-pathologic correlation Part 1. Benign tumors. Radiographics 30:801–826
20.
go back to reference Sieders E, Peeters PMJG, Ten Vergert EM et al (2000) Early vascular complications after pediatric liver transplantation. Liver Transpl 6:326–332PubMedCrossRef Sieders E, Peeters PMJG, Ten Vergert EM et al (2000) Early vascular complications after pediatric liver transplantation. Liver Transpl 6:326–332PubMedCrossRef
21.
go back to reference Feier FH, Da Fonseca EA, Seda-Neto J, Chapchap P (2015) Biliary complications after pediatric liver transplantation: risk factors, diagnosis and management. World J Hepatol 7:2162–2170PubMedPubMedCentralCrossRef Feier FH, Da Fonseca EA, Seda-Neto J, Chapchap P (2015) Biliary complications after pediatric liver transplantation: risk factors, diagnosis and management. World J Hepatol 7:2162–2170PubMedPubMedCentralCrossRef
22.
go back to reference Horvat N, Marcelino ASZ, Horvat JV et al (2017) Pediatric liver transplant: techniques and complications. Radiographics 37:1612–1631PubMedCrossRef Horvat N, Marcelino ASZ, Horvat JV et al (2017) Pediatric liver transplant: techniques and complications. Radiographics 37:1612–1631PubMedCrossRef
23.
go back to reference Gore RM, Pickhardt PJ, Mortele KJ et al (2017) Management of incidental liver lesions on CT: a white paper of the ACR incidental findings committee. J Am Coll Radiol 14:1429–1437PubMedCrossRef Gore RM, Pickhardt PJ, Mortele KJ et al (2017) Management of incidental liver lesions on CT: a white paper of the ACR incidental findings committee. J Am Coll Radiol 14:1429–1437PubMedCrossRef
24.
go back to reference Adeyiga AO, Lee EY, Eisenberg RL (2012) Focal hepatic masses in pediatric patients. AJR Am J Roentgenol 199:W422–W440PubMedCrossRef Adeyiga AO, Lee EY, Eisenberg RL (2012) Focal hepatic masses in pediatric patients. AJR Am J Roentgenol 199:W422–W440PubMedCrossRef
25.
go back to reference Malviya S, Voepel-Lewis T, Eldevik OP et al (2000) Sedation and general anaesthesia in children undergoing MRI and CT: adverse events and outcomes. Br J Anaesth 84:743–748PubMedCrossRef Malviya S, Voepel-Lewis T, Eldevik OP et al (2000) Sedation and general anaesthesia in children undergoing MRI and CT: adverse events and outcomes. Br J Anaesth 84:743–748PubMedCrossRef
26.
go back to reference Davidson AJ, Disma N, De Graaff JC et al (2016) Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial. Lancet 387:239–250PubMedCrossRef Davidson AJ, Disma N, De Graaff JC et al (2016) Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial. Lancet 387:239–250PubMedCrossRef
27.
go back to reference Nardone B, Saddleton E, Laumann AE et al (2014) Pediatric nephrogenic systemic fibrosis is rarely reported: a RADAR report. Pediatr Radiol 44:173–180PubMedCrossRef Nardone B, Saddleton E, Laumann AE et al (2014) Pediatric nephrogenic systemic fibrosis is rarely reported: a RADAR report. Pediatr Radiol 44:173–180PubMedCrossRef
28.
go back to reference Blumfield E, Swenson DW, Iyer RS, Stanescu AL (2019) Gadolinium-based contrast agents — review of recent literature on magnetic resonance imaging signal intensity changes and tissue deposits, with emphasis on pediatric patients. Pediatr Radiol 49:448–457PubMedCrossRef Blumfield E, Swenson DW, Iyer RS, Stanescu AL (2019) Gadolinium-based contrast agents — review of recent literature on magnetic resonance imaging signal intensity changes and tissue deposits, with emphasis on pediatric patients. Pediatr Radiol 49:448–457PubMedCrossRef
29.
go back to reference Neri E, Bali MA, Ba-Ssalamah A et al (2016) ESGAR consensus statement on liver MR imaging and clinical use of liver-specific contrast agents. Eur Radiol 26:921–931CrossRefPubMed Neri E, Bali MA, Ba-Ssalamah A et al (2016) ESGAR consensus statement on liver MR imaging and clinical use of liver-specific contrast agents. Eur Radiol 26:921–931CrossRefPubMed
30.
go back to reference Meyers AB, Towbin AJ, Serai S et al (2011) Characterization of pediatric liver lesions with gadoxetate disodium. Pediatr Radiol 41:1183–1197PubMedCrossRef Meyers AB, Towbin AJ, Serai S et al (2011) Characterization of pediatric liver lesions with gadoxetate disodium. Pediatr Radiol 41:1183–1197PubMedCrossRef
31.
go back to reference Lauenstein T, Ramirez-Garrido F, Kim YH et al (2015) Nephrogenic systemic fibrosis risk after liver magnetic resonance imaging with gadoxetate disodium in patients with moderate to severe renal impairment: results of a prospective, open-label, multicenter study. Investig Radiol 50:416–422CrossRef Lauenstein T, Ramirez-Garrido F, Kim YH et al (2015) Nephrogenic systemic fibrosis risk after liver magnetic resonance imaging with gadoxetate disodium in patients with moderate to severe renal impairment: results of a prospective, open-label, multicenter study. Investig Radiol 50:416–422CrossRef
32.
go back to reference Barber JL, Shah N, Watson TA (2018) Early onset inflammatory bowel disease — what the radiologist needs to know. Eur J Radiol 106:173–182PubMedCrossRef Barber JL, Shah N, Watson TA (2018) Early onset inflammatory bowel disease — what the radiologist needs to know. Eur J Radiol 106:173–182PubMedCrossRef
33.
go back to reference Sadigh S, Chopra M, Sury MR et al (2017) Paediatric magnetic resonance enteroclysis under general anaesthesia — initial experience. Pediatr Radiol 47:877–883PubMedCrossRef Sadigh S, Chopra M, Sury MR et al (2017) Paediatric magnetic resonance enteroclysis under general anaesthesia — initial experience. Pediatr Radiol 47:877–883PubMedCrossRef
34.
go back to reference Mathews JD, Forsythe AV, Brady Z et al (2013) Cancer risk in 680,000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians. BMJ 346:f2360PubMedPubMedCentralCrossRef Mathews JD, Forsythe AV, Brady Z et al (2013) Cancer risk in 680,000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians. BMJ 346:f2360PubMedPubMedCentralCrossRef
35.
go back to reference De Gonzalez AB, Salotti JA, McHugh K et al (2016) Relationship between paediatric CT scans and subsequent risk of leukaemia and brain tumours: assessment of the impact of underlying conditions. Br J Cancer 114:388–394PubMedCentralCrossRef De Gonzalez AB, Salotti JA, McHugh K et al (2016) Relationship between paediatric CT scans and subsequent risk of leukaemia and brain tumours: assessment of the impact of underlying conditions. Br J Cancer 114:388–394PubMedCentralCrossRef
36.
go back to reference Singh S, Kalra MK, Shenoy-Bhangle AS et al (2012) Radiation dose reduction with hybrid iterative reconstruction for pediatric CT. Radiology 263:537–546PubMedCrossRef Singh S, Kalra MK, Shenoy-Bhangle AS et al (2012) Radiation dose reduction with hybrid iterative reconstruction for pediatric CT. Radiology 263:537–546PubMedCrossRef
37.
go back to reference Nievelstein RAJ, Robben SGF, Blickman JG (2011) Hepatobiliary and pancreatic imaging in children — techniques and an overview of non-neoplastic disease entities. Pediatr Radiol 41:55–75PubMedCrossRef Nievelstein RAJ, Robben SGF, Blickman JG (2011) Hepatobiliary and pancreatic imaging in children — techniques and an overview of non-neoplastic disease entities. Pediatr Radiol 41:55–75PubMedCrossRef
38.
go back to reference Rozell JM, Catanzano T, Polansky SM et al (2014) Primary liver tumors in pediatric patients: proper imaging technique for diagnosis and staging. Semin Ultrasound CT MRI 35:382–393CrossRef Rozell JM, Catanzano T, Polansky SM et al (2014) Primary liver tumors in pediatric patients: proper imaging technique for diagnosis and staging. Semin Ultrasound CT MRI 35:382–393CrossRef
39.
go back to reference Ntoulia A, Back SJ, Shellikeri S et al (2018) Contrast-enhanced voiding urosonography (ceVUS) with the intravesical administration of the ultrasound contrast agent Optison™ for vesicoureteral reflux detection in children: a prospective clinical trial. Pediatr Radiol 48:216–226PubMedCrossRef Ntoulia A, Back SJ, Shellikeri S et al (2018) Contrast-enhanced voiding urosonography (ceVUS) with the intravesical administration of the ultrasound contrast agent Optison™ for vesicoureteral reflux detection in children: a prospective clinical trial. Pediatr Radiol 48:216–226PubMedCrossRef
40.
go back to reference Claudon M, Dietrich CF, Choi BI et al (2013) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver — update 2012. A WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultrasound Med Biol 39:187–210PubMedCrossRef Claudon M, Dietrich CF, Choi BI et al (2013) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver — update 2012. A WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultrasound Med Biol 39:187–210PubMedCrossRef
41.
go back to reference Claudon M, Cosgrove D, Albrecht T et al (2008) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) — update 2008. Ultraschall Med 29:28–44PubMedCrossRef Claudon M, Cosgrove D, Albrecht T et al (2008) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) — update 2008. Ultraschall Med 29:28–44PubMedCrossRef
42.
go back to reference Strobel D, Seitz K, Blank W et al (2008) Contrast-enhanced ultrasound for the characterization of focal liver lesions — diagnostic accuracy in clinical practice (DEGUM multicenter trial). Ultraschall Med 29:499–505PubMedCrossRef Strobel D, Seitz K, Blank W et al (2008) Contrast-enhanced ultrasound for the characterization of focal liver lesions — diagnostic accuracy in clinical practice (DEGUM multicenter trial). Ultraschall Med 29:499–505PubMedCrossRef
43.
go back to reference Chiorean L, Cui XW, Tannapfel A et al (2015) Benign liver tumors in pediatric patients — review with emphasis on imaging features. World J Gastroenterol 21:8541–8561PubMedPubMedCentralCrossRef Chiorean L, Cui XW, Tannapfel A et al (2015) Benign liver tumors in pediatric patients — review with emphasis on imaging features. World J Gastroenterol 21:8541–8561PubMedPubMedCentralCrossRef
44.
go back to reference Jacob J, Deganello A, Sellars ME et al (2013) Contrast enhanced ultrasound (CEUS) characterization of grey-scale sonographic indeterminate focal liver lesions in pediatric practice. Ultraschall Med 34:529–540PubMedCrossRef Jacob J, Deganello A, Sellars ME et al (2013) Contrast enhanced ultrasound (CEUS) characterization of grey-scale sonographic indeterminate focal liver lesions in pediatric practice. Ultraschall Med 34:529–540PubMedCrossRef
45.
go back to reference Bonini G, Pezzotta G, Morzenti C et al (2007) Contrast-enhanced ultrasound with SonoVue in the evaluation of postoperative complications in pediatric liver transplant recipients. J Ultrasound 10:99–106PubMedPubMedCentralCrossRef Bonini G, Pezzotta G, Morzenti C et al (2007) Contrast-enhanced ultrasound with SonoVue in the evaluation of postoperative complications in pediatric liver transplant recipients. J Ultrasound 10:99–106PubMedPubMedCentralCrossRef
46.
go back to reference Rennert J, Dornia C, Georgieva M et al (2012) Identification of early complications following liver transplantation using contrast enhanced ultrasound (CEUS). First results. J Gastrointest Liver Dis 21:407–412 Rennert J, Dornia C, Georgieva M et al (2012) Identification of early complications following liver transplantation using contrast enhanced ultrasound (CEUS). First results. J Gastrointest Liver Dis 21:407–412
47.
go back to reference Valentino M, Serra C, Pavlica P et al (2008) Blunt abdominal trauma: diagnostic performance of contrast-enhanced US in children — initial experience. Radiology 246:903–909PubMedCrossRef Valentino M, Serra C, Pavlica P et al (2008) Blunt abdominal trauma: diagnostic performance of contrast-enhanced US in children — initial experience. Radiology 246:903–909PubMedCrossRef
48.
go back to reference Menichini G, Sessa B, Trinci M et al (2015) Accuracy of contrast-enhanced ultrasound (CEUS) in the identification and characterization of traumatic solid organ lesions in children: a retrospective comparison with baseline US and CE-MDCT. Radiol Med 120:989–1001PubMedCrossRef Menichini G, Sessa B, Trinci M et al (2015) Accuracy of contrast-enhanced ultrasound (CEUS) in the identification and characterization of traumatic solid organ lesions in children: a retrospective comparison with baseline US and CE-MDCT. Radiol Med 120:989–1001PubMedCrossRef
49.
go back to reference Medellin-Kowalewski A, Wilkens R, Wilson A et al (2016) Quantitative contrast-enhanced ultrasound parameters in Crohn disease: their role in disease activity determination with ultrasound. AJR Am J Roentgenol 206:64–73PubMedCrossRef Medellin-Kowalewski A, Wilkens R, Wilson A et al (2016) Quantitative contrast-enhanced ultrasound parameters in Crohn disease: their role in disease activity determination with ultrasound. AJR Am J Roentgenol 206:64–73PubMedCrossRef
50.
go back to reference Fontanilla T, Cañas T, Macia A et al (2014) Normal values of liver shear wave velocity in healthy children assessed by acoustic radiation force impulse imaging using a convex probe and a linear probe. Ultrasound Med Biol 40:470–477PubMedCrossRef Fontanilla T, Cañas T, Macia A et al (2014) Normal values of liver shear wave velocity in healthy children assessed by acoustic radiation force impulse imaging using a convex probe and a linear probe. Ultrasound Med Biol 40:470–477PubMedCrossRef
51.
go back to reference Yoon JH, Lee JM, Han JK, Choi BI (2014) Shear wave elastography for liver stiffness measurement in clinical sonographic examinations: evaluation of intraobserver reproducibility, technical failure, and unreliable stiffness measurements. J Ultrasound Med 33:437–447PubMedCrossRef Yoon JH, Lee JM, Han JK, Choi BI (2014) Shear wave elastography for liver stiffness measurement in clinical sonographic examinations: evaluation of intraobserver reproducibility, technical failure, and unreliable stiffness measurements. J Ultrasound Med 33:437–447PubMedCrossRef
52.
go back to reference Dillman JR, Heider A, Bilhartz JL et al (2015) Ultrasound shear wave speed measurements correlate with liver fibrosis in children. Pediatr Radiol 45:1480–1488PubMedPubMedCentralCrossRef Dillman JR, Heider A, Bilhartz JL et al (2015) Ultrasound shear wave speed measurements correlate with liver fibrosis in children. Pediatr Radiol 45:1480–1488PubMedPubMedCentralCrossRef
53.
go back to reference Franchi-Abella S, Corno L, Gonzales E et al (2016) Feasibility and diagnostic accuracy of supersonic shear-wave elastography for the assessment of liver stiffness and liver fibrosis in children: a pilot study of 96 patients. Radiology 278:554–562PubMedCrossRef Franchi-Abella S, Corno L, Gonzales E et al (2016) Feasibility and diagnostic accuracy of supersonic shear-wave elastography for the assessment of liver stiffness and liver fibrosis in children: a pilot study of 96 patients. Radiology 278:554–562PubMedCrossRef
54.
go back to reference Özkan MB, Bilgici MC, Eren E et al (2017) Role of point shear wave elastography in the determination of the severity of fibrosis in pediatric liver diseases with pathologic correlations. J Ultrasound Med 36:2337–2344PubMedCrossRef Özkan MB, Bilgici MC, Eren E et al (2017) Role of point shear wave elastography in the determination of the severity of fibrosis in pediatric liver diseases with pathologic correlations. J Ultrasound Med 36:2337–2344PubMedCrossRef
55.
go back to reference Fierbinteanu-Braticevici C, Andronescu D, Usvat R et al (2009) Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis. World J Gastroenterol 15:5525–5532PubMedPubMedCentralCrossRef Fierbinteanu-Braticevici C, Andronescu D, Usvat R et al (2009) Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis. World J Gastroenterol 15:5525–5532PubMedPubMedCentralCrossRef
56.
go back to reference Summers JA, Radhakrishnan M, Morris E et al (2017) Virtual Touch™ quantification to diagnose and monitor liver fibrosis in Hepatitis B and Hepatitis C: a NICE medical technology guidance. Appl Health Econ Health Policy 15:139–154 Summers JA, Radhakrishnan M, Morris E et al (2017) Virtual Touch™ quantification to diagnose and monitor liver fibrosis in Hepatitis B and Hepatitis C: a NICE medical technology guidance. Appl Health Econ Health Policy 15:139–154
57.
go back to reference Hanquinet S, Courvoisier DS, Rougemont AL et al (2016) Acoustic radiation force impulse sonography in assessing children with biliary atresia for liver transplantation. Pediatr Radiol 46:1011–1016PubMedCrossRef Hanquinet S, Courvoisier DS, Rougemont AL et al (2016) Acoustic radiation force impulse sonography in assessing children with biliary atresia for liver transplantation. Pediatr Radiol 46:1011–1016PubMedCrossRef
58.
go back to reference Zhou L-Y, Jiang H, Shan Q-Y et al (2017) Liver stiffness measurements with supersonic shear wave elastography in the diagnosis of biliary atresia: a comparative study with grey-scale US. Eur Radiol 27:3474–3484PubMedCrossRef Zhou L-Y, Jiang H, Shan Q-Y et al (2017) Liver stiffness measurements with supersonic shear wave elastography in the diagnosis of biliary atresia: a comparative study with grey-scale US. Eur Radiol 27:3474–3484PubMedCrossRef
59.
go back to reference Dillman JR, Stidham RW, Higgins PDR et al (2013) US elastography-derived shear wave velocity helps distinguish acutely inflamed from fibrotic bowel in a Crohn disease animal model. Radiology 267:757–766PubMedCrossRef Dillman JR, Stidham RW, Higgins PDR et al (2013) US elastography-derived shear wave velocity helps distinguish acutely inflamed from fibrotic bowel in a Crohn disease animal model. Radiology 267:757–766PubMedCrossRef
60.
go back to reference Taylor SA, Mallett S, Bhatnagar G et al (2018) Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed Crohn’s disease (METRIC): a multicentre trial. Lancet Gastroenterol Hepatol 3:548–558PubMedPubMedCentralCrossRef Taylor SA, Mallett S, Bhatnagar G et al (2018) Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed Crohn’s disease (METRIC): a multicentre trial. Lancet Gastroenterol Hepatol 3:548–558PubMedPubMedCentralCrossRef
62.
go back to reference Ream JM, Dillman JR, Adler J et al (2013) MRI diffusion-weighted imaging (DWI) in pediatric small bowel Crohn disease: correlation with MRI findings of active bowel wall inflammation. Pediatr Radiol 43:1077–1085PubMedCrossRef Ream JM, Dillman JR, Adler J et al (2013) MRI diffusion-weighted imaging (DWI) in pediatric small bowel Crohn disease: correlation with MRI findings of active bowel wall inflammation. Pediatr Radiol 43:1077–1085PubMedCrossRef
63.
go back to reference Watson T, Calder A, Barber JL (2018) Quantitative bowel apparent diffusion coefficient measurements in children with inflammatory bowel disease are not reproducible. Clin Radiol 73:574–579PubMedCrossRef Watson T, Calder A, Barber JL (2018) Quantitative bowel apparent diffusion coefficient measurements in children with inflammatory bowel disease are not reproducible. Clin Radiol 73:574–579PubMedCrossRef
64.
go back to reference Khachab F, Loundou A, Roman C et al (2018) Can diffusion weighting replace gadolinium enhancement in magnetic resonance enterography for inflammatory bowel disease in children? Pediatr Radiol 48:1432–1440PubMedCrossRef Khachab F, Loundou A, Roman C et al (2018) Can diffusion weighting replace gadolinium enhancement in magnetic resonance enterography for inflammatory bowel disease in children? Pediatr Radiol 48:1432–1440PubMedCrossRef
65.
go back to reference Parikh T, Drew SJ, Lee VS et al (2008) Focal liver lesion detection and characterization with diffusion-weighted MR imaging: comparison with standard breath-hold T2-weighted imaging. Radiology 246:812–822PubMedCrossRef Parikh T, Drew SJ, Lee VS et al (2008) Focal liver lesion detection and characterization with diffusion-weighted MR imaging: comparison with standard breath-hold T2-weighted imaging. Radiology 246:812–822PubMedCrossRef
66.
go back to reference Caro-Domínguez P, Gupta AA, Chavhan GB (2018) Can diffusion-weighted imaging distinguish between benign and malignant pediatric liver tumors? Pediatr Radiol 48:85–93PubMedCrossRef Caro-Domínguez P, Gupta AA, Chavhan GB (2018) Can diffusion-weighted imaging distinguish between benign and malignant pediatric liver tumors? Pediatr Radiol 48:85–93PubMedCrossRef
67.
go back to reference Froehlich JM, Waldherr C, Stoupis C et al (2010) MR motility imaging in Crohn’s disease improves lesion detection compared with standard MR imaging. Eur Radiol 20:1945–1951PubMedCrossRef Froehlich JM, Waldherr C, Stoupis C et al (2010) MR motility imaging in Crohn’s disease improves lesion detection compared with standard MR imaging. Eur Radiol 20:1945–1951PubMedCrossRef
68.
go back to reference Menys A, Puylaert C, Tutein Nolthenius CE et al (2018) Quantified terminal ileal motility during MR enterography as a biomarker of Crohn disease activity: prospective multi-institution study. Radiology 289:428–435PubMedCrossRef Menys A, Puylaert C, Tutein Nolthenius CE et al (2018) Quantified terminal ileal motility during MR enterography as a biomarker of Crohn disease activity: prospective multi-institution study. Radiology 289:428–435PubMedCrossRef
69.
go back to reference Plumb AA, Menys A, Russo E et al (2015) Magnetic resonance imaging-quantified small bowel motility is a sensitive marker of response to medical therapy in Crohn’s disease. Aliment Pharmacol Ther 42:343–355PubMedCrossRef Plumb AA, Menys A, Russo E et al (2015) Magnetic resonance imaging-quantified small bowel motility is a sensitive marker of response to medical therapy in Crohn’s disease. Aliment Pharmacol Ther 42:343–355PubMedCrossRef
70.
go back to reference Menys A, Hoad C, Spiller R et al (2019) Spatio-temporal motility MRI analysis of the stomach and colon. Neurogastroenterol Motil 31:e13557PubMedCrossRef Menys A, Hoad C, Spiller R et al (2019) Spatio-temporal motility MRI analysis of the stomach and colon. Neurogastroenterol Motil 31:e13557PubMedCrossRef
71.
go back to reference Menys A, Keszthelyi D, Fitzke H et al (2017) A magnetic resonance imaging study of gastric motor function in patients with dyspepsia associated with Ehlers-Danlos syndrome-hypermobility type: a feasibility study. Neurogastroenterol Motil 29:e13090CrossRef Menys A, Keszthelyi D, Fitzke H et al (2017) A magnetic resonance imaging study of gastric motor function in patients with dyspepsia associated with Ehlers-Danlos syndrome-hypermobility type: a feasibility study. Neurogastroenterol Motil 29:e13090CrossRef
72.
go back to reference Adler J, Swanson SD, Rahal K et al (2011) Magnetization transfer MRI detects change in bowel wall fibrosis with TNFα antagonist therapy in a rat model of Crohn’s disease. Gastroenterology 140:S761CrossRef Adler J, Swanson SD, Rahal K et al (2011) Magnetization transfer MRI detects change in bowel wall fibrosis with TNFα antagonist therapy in a rat model of Crohn’s disease. Gastroenterology 140:S761CrossRef
73.
go back to reference Li X, Mao R, Huang S et al (2018) Characterization of degree of intestinal fibrosis in patients with Crohn disease by using magnetization transfer MR imaging. Radiology 287:494–503PubMedCrossRef Li X, Mao R, Huang S et al (2018) Characterization of degree of intestinal fibrosis in patients with Crohn disease by using magnetization transfer MR imaging. Radiology 287:494–503PubMedCrossRef
74.
go back to reference Donato H, França M, Candelária I, Caseiro-Alves F (2017) Liver MRI: from basic protocol to advanced techniques. Eur J Radiol 93:30–39PubMedCrossRef Donato H, França M, Candelária I, Caseiro-Alves F (2017) Liver MRI: from basic protocol to advanced techniques. Eur J Radiol 93:30–39PubMedCrossRef
75.
go back to reference Henninger B, Alustiza J, Garbowski M, Gandon Y (2020) Practical guide to quantification of hepatic iron with MRI. Eur Radiol 30:383–393PubMedCrossRef Henninger B, Alustiza J, Garbowski M, Gandon Y (2020) Practical guide to quantification of hepatic iron with MRI. Eur Radiol 30:383–393PubMedCrossRef
76.
go back to reference Dillman JR, Trout AT, Costello EN et al (2018) Quantitative liver MRI–biopsy correlation in pediatric and young adult patients with nonalcoholic fatty liver disease: can one be used to predict the other? AJR Am J Roentgenol 210:166–174PubMedCrossRef Dillman JR, Trout AT, Costello EN et al (2018) Quantitative liver MRI–biopsy correlation in pediatric and young adult patients with nonalcoholic fatty liver disease: can one be used to predict the other? AJR Am J Roentgenol 210:166–174PubMedCrossRef
77.
go back to reference Tang A, Tan J, Sun M et al (2013) Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis. Radiology 267:422–431PubMedPubMedCentralCrossRef Tang A, Tan J, Sun M et al (2013) Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis. Radiology 267:422–431PubMedPubMedCentralCrossRef
78.
go back to reference Verlhac S, Morel M, Bernaudin F et al (2015) Liver iron overload assessment by MRI R2∗ relaxometry in highly transfused pediatric patients: an agreement and reproducibility study. Diagn Interv Imaging 96:259–264PubMedCrossRef Verlhac S, Morel M, Bernaudin F et al (2015) Liver iron overload assessment by MRI R2∗ relaxometry in highly transfused pediatric patients: an agreement and reproducibility study. Diagn Interv Imaging 96:259–264PubMedCrossRef
79.
80.
go back to reference Serai SD, Towbin AJ, Podberesky DJ (2012) Pediatric liver MR elastography. Dig Dis Sci 57:2713–2719PubMedCrossRef Serai SD, Towbin AJ, Podberesky DJ (2012) Pediatric liver MR elastography. Dig Dis Sci 57:2713–2719PubMedCrossRef
81.
go back to reference Xanthakos SA, Podberesky DJ, Serai SD et al (2014) Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease. J Pediatr 164:186–188PubMedCrossRef Xanthakos SA, Podberesky DJ, Serai SD et al (2014) Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease. J Pediatr 164:186–188PubMedCrossRef
82.
go back to reference Joshi M, Dillman JR, Towbin AJ et al (2017) MR elastography: high rate of technical success in pediatric and young adult patients. Pediatr Radiol 47:838–843PubMedCrossRef Joshi M, Dillman JR, Towbin AJ et al (2017) MR elastography: high rate of technical success in pediatric and young adult patients. Pediatr Radiol 47:838–843PubMedCrossRef
83.
go back to reference Schechter T, Perez-Albuerne E, Lin TF et al (2018) Veno-occlusive disease after high-dose busulfan–melphalan in neuroblastoma. Bone Marrow Transplant 55:531–537PubMedCrossRef Schechter T, Perez-Albuerne E, Lin TF et al (2018) Veno-occlusive disease after high-dose busulfan–melphalan in neuroblastoma. Bone Marrow Transplant 55:531–537PubMedCrossRef
84.
go back to reference McCarville MB, Hoffer FA, Howard SC et al (2001) Hepatic veno-occlusive disease in children undergoing bone-marrow transplantation: usefulness of sonographic findings. Pediatr Radiol 31:102–105PubMedCrossRef McCarville MB, Hoffer FA, Howard SC et al (2001) Hepatic veno-occlusive disease in children undergoing bone-marrow transplantation: usefulness of sonographic findings. Pediatr Radiol 31:102–105PubMedCrossRef
85.
go back to reference Lassau N, Auperin A, Leclere J et al (2002) Prognostic value of Doppler-ultrasonography in hepatic veno-occlusive disease. Transplantation 74:60–66PubMedCrossRef Lassau N, Auperin A, Leclere J et al (2002) Prognostic value of Doppler-ultrasonography in hepatic veno-occlusive disease. Transplantation 74:60–66PubMedCrossRef
86.
go back to reference Fontanilla T, Hernando CG, Claros JCV et al (2011) Acoustic radiation force impulse elastography and contrast-enhanced sonography of sinusoidal obstructive syndrome (veno-occlusive disease): preliminary results. J Ultrasound Med 30:1593–1598PubMedCrossRef Fontanilla T, Hernando CG, Claros JCV et al (2011) Acoustic radiation force impulse elastography and contrast-enhanced sonography of sinusoidal obstructive syndrome (veno-occlusive disease): preliminary results. J Ultrasound Med 30:1593–1598PubMedCrossRef
87.
go back to reference Lubner MG, Menias CO, Agrons M et al (2017) Imaging of abdominal and pelvic manifestations of graft-versus-host disease after hematopoietic stem cell transplant. AJR Am J Roentgenol 209:33–45PubMedCrossRef Lubner MG, Menias CO, Agrons M et al (2017) Imaging of abdominal and pelvic manifestations of graft-versus-host disease after hematopoietic stem cell transplant. AJR Am J Roentgenol 209:33–45PubMedCrossRef
88.
go back to reference Brodoefel H, Bethge W, Vogel M et al (2010) Early and late-onset acute GvHD following hematopoietic cell transplantation: CT features of gastrointestinal involvement with clinical and pathological correlation. Eur J Radiol 73:594–600PubMedCrossRef Brodoefel H, Bethge W, Vogel M et al (2010) Early and late-onset acute GvHD following hematopoietic cell transplantation: CT features of gastrointestinal involvement with clinical and pathological correlation. Eur J Radiol 73:594–600PubMedCrossRef
89.
go back to reference Nishida M, Shigematsu A, Sato M et al (2015) Ultrasonographic evaluation of gastrointestinal graft-versus-host disease after hematopoietic stem cell transplantation. Clin Transpl 29:697–704CrossRef Nishida M, Shigematsu A, Sato M et al (2015) Ultrasonographic evaluation of gastrointestinal graft-versus-host disease after hematopoietic stem cell transplantation. Clin Transpl 29:697–704CrossRef
90.
go back to reference Sebire NJ, Malone M, Risdon RA, Ramsay AD (2005) Epstein-Barr virus-associated lymphoproliferative disorder presenting as apparently isolated gastrointestinal lesions in childhood. Pediatr Dev Pathol 8:88–91PubMedCrossRef Sebire NJ, Malone M, Risdon RA, Ramsay AD (2005) Epstein-Barr virus-associated lymphoproliferative disorder presenting as apparently isolated gastrointestinal lesions in childhood. Pediatr Dev Pathol 8:88–91PubMedCrossRef
Metadata
Title
Paediatric gastrointestinal and hepatobiliary radiology: why do we need subspecialists, and what is new?
Authors
Tom A. Watson
Joy Barber
Helen Woodley
Publication date
01-04-2021
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Radiology / Issue 4/2021
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-020-04778-y

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