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Archives of Gynecology and Obstetrics

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01-01-2019 | General Gynecology

Oxytocin infusion reduces bleeding during abdominal myomectomies: a randomized controlled trial

Authors: Berna Aslan Çetin, Begüm Aydoğan Mathyk, Nadiye Köroğlu, Ali Soydar, Gökhan Demirayak, Tayfur Çift

Published in: Archives of Gynecology and Obstetrics | Issue 1/2019

Abstract

Purpose

To evaluate the effectiveness of oxytocin infusion to reduce intraoperative bleeding during abdominal myomectomies.

Methods

This randomized, parallel group, blinded study was conducted between October 2017 and May 2018. Patients undergoing abdominal myomectomies were randomized 1:1 either to the oxytocin group or to the control group (saline). In the oxytocin group, 10 IU oxytocin in 500 ml of saline at a rate of 120 ml/h was given during the course of the operation. The primary outcome of this study was to measure intraoperative blood loss between the study groups. Correlation and multiple regression analysis were performed to illustrate factors associated with intraoperative blood loss during the myomectomy.

Results

The mean intraoperative blood loss during the surgery was 489.20 ± 239.72 ml in the oxytocin group and was 641.40 ± 288.21 ml in the control group. The hemoglobin decline was more evident in the control group than in the oxytocin group. Positive correlations were also observed between the intraoperative blood loss and number of fibroids removed during the surgery, largest fibroid removed and weight of fibroids removed. The use of oxytocin infusion during the myomectomy resulted in a reduction of bleeding in the regression model.

Conclusion

Intravenous oxytocin infusion is a safe and practical method to reduce intraoperative blood loss during the abdominal myomectomy.

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Title: Oxytocin infusion reduces bleeding during abdominal myomectomies: a randomized controlled trial
Authors: Berna Aslan Çetin
Begüm Aydoğan Mathyk
Nadiye Köroğlu
Ali Soydar
Gökhan Demirayak
Tayfur Çift
Publication date: 01-01-2019
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 1/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-4944-9

At a glance: The STEP trials

Springer Medicine

Oxytocin infusion reduces bleeding during abdominal myomectomies: a randomized controlled trial

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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