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Published in: Archives of Gynecology and Obstetrics 1/2012

01-01-2012 | General Gynecology

Intravenous ascorbic acid (vitamin C) administration in myomectomy: a prospective, randomized, clinical trial

Authors: Elham Pourmatroud, Leila Hormozi, Masoud Hemadi, Roza Golshahi

Published in: Archives of Gynecology and Obstetrics | Issue 1/2012

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Abstract

Background

To assess the usefulness of using ascorbic acid (vitamin C) administration in abdominal myomectomy.

Materials and methods

A total of 102 patients were divided two groups in this prospective, clinical trial. Group A had received 2 g of ascorbic acid during a myomectomy, and group B had a myomectomy without any interventions. The operative time, blood loss, days of hospitalization, post-operative complications and rate of blood transfusions were compared between the two groups.

Results

The blood loss (521.44 ± 199.24 vs. 932.9 ± 264.38 ml; p value <0.001), duration of the operation time (42 ± 13.9 vs. 68 ± 21.7 min; p value <0.001), days of hospitalization (2.7 ± 0.69 vs. 3.1 ± 0.59 days; p value 0.002) in group A were significantly less than in group B (p value 0.001). The chance risk ratio of a blood transfusion in group A was 0.4 (7.7 vs. 18% 95% CI of 0.1–1; p value 0.07). There was a significant correlation between the volume of bleeding and post-operative complications in both groups (p value in group A = 0.03; in group B = 0.004).

Conclusion

The administration of ascorbic acid (vitamin C) in abdominal myomectomy could reduce the blood loss during the procedure, operation time and days of hospitalization.
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Metadata
Title
Intravenous ascorbic acid (vitamin C) administration in myomectomy: a prospective, randomized, clinical trial
Authors
Elham Pourmatroud
Leila Hormozi
Masoud Hemadi
Roza Golshahi
Publication date
01-01-2012
Publisher
Springer-Verlag
Published in
Archives of Gynecology and Obstetrics / Issue 1/2012
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-011-1897-7

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