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Cancer Cell International
Published in: Cancer Cell International 1/2020

01-12-2020 | Ovarian Cancer | Review

Insight into the role of p62 in the cisplatin resistant mechanisms of ovarian cancer

Authors: Xiao-Yu Yan, Xian-Zhi Qu, Long Xu, Si-Hang Yu, Rui Tian, Xin-Ru Zhong, Lian-Kun Sun, Jing Su

Published in: Cancer Cell International | Issue 1/2020

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Abstract

Cisplatin is a platinum-based first-line drug for treating ovarian cancer. However, chemotherapy tolerance has limited the efficacy of cisplatin for ovarian cancer patients. Research has demonstrated that cisplatin causes changes in cell survival and death signaling pathways through its interaction with macromolecules and organelles, which indicates that investigation into the DNA off-target effects of cisplatin may provide critical insights into the mechanisms underlying drug resistance. The multifunctional protein p62 works as a signaling hub in the regulation of pro-survival transcriptional factors NF-κB and Nrf2 and connects autophagy and apoptotic signals, which play important roles in maintaining cell homeostasis. In this review, we discuss the role of p62 in cisplatin resistance by exploring p62-associated signaling pathways based on current studies and our work. Insights into these resistance mechanisms may lead to more effective therapeutic strategies for ovarian cancer by targeting p62.
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Metadata
Title
Insight into the role of p62 in the cisplatin resistant mechanisms of ovarian cancer
Authors
Xiao-Yu Yan
Xian-Zhi Qu
Long Xu
Si-Hang Yu
Rui Tian
Xin-Ru Zhong
Lian-Kun Sun
Jing Su
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2020
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-020-01196-w

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