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Archives of Gynecology and Obstetrics

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01-03-2019 | Ovarian Cancer | Review

Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis

Authors: Xiaqin Huo, Liang Yao, Xue Han, Wen Li, Junjuan Liu, Lijun Zhou, Yuanfeng Gou, Kehu Yang, Huiling Liu

Published in: Archives of Gynecology and Obstetrics | Issue 3/2019

Abstract

Purpose

The association between hysterectomy for benign gynecologic disease and ovarian cancer risk was controversial. Thus, we perform a systematic review and meta-analysis to evaluate the effect of hysterectomy and ovarian cancer risk.

Methods

PubMed, Cochrane Library, and Embase were searched from 2000 toJanuary 2018. A random-effect model was used to obtain the summary odds risks (ORs) and 95% confidence intervals (CIs).

Results

A total of 18 case–control studies were included in the meta-analysis. We found that there was no statistical significance for ovarian cancer risk following hysterectomy (OR 0.97, 95% CI 0.83–1.12). And in subgroup analysis, the protective effects were observed for invasive endometrioid/clear cell carcinomas after hysterectomy (OR 0.70, 95% CI 0.51, 0.94; I² = 0%), and no statistical significance for serous and mucinous.

Conclusions

Hysterectomy showed no relationship with ovarian cancer. But a reduced risk was found for endometrioid-invasive OC. These findings could provide evidence for patients with benign gynecological disease and clinicians to make appropriate decision about whether to conduct hysterectomy.

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Title: Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis
Authors: Xiaqin Huo
Liang Yao
Xue Han
Wen Li
Junjuan Liu
Lijun Zhou
Yuanfeng Gou
Kehu Yang
Huiling Liu
Publication date: 01-03-2019
Publisher: Springer Berlin Heidelberg
Keywords: Ovarian Cancer
Ovarian Cancer
Hysterectomy
Published in: Archives of Gynecology and Obstetrics / Issue 3/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-5020-1

At a glance: The STEP trials

Springer Medicine

Hysterectomy and risk of ovarian cancer: a systematic review and meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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