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Cancer Cell International
Published in: Cancer Cell International 1/2021

Open Access 01-12-2021 | osteosarcoma | Review

Anti-cancer properties of quercetin in osteosarcoma

Authors: Parisa Maleki Dana, Fatemeh Sadoughi, Zatollah Asemi, Bahman Yousefi

Published in: Cancer Cell International | Issue 1/2021

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Abstract

Osteosarcoma is a primary bone tumor. Although it is a rare disease in general, it is the most common primary bone tumor among children. Despite the significant advances made in the field of osteosarcoma treatment, the outcomes of this disease are still unfavorable. Besides, there is still no targeted therapy for osteosarcoma that can be used in clinical settings. Quercetin is a member of the phytochemical family which is used for different diseases including cardiovascular diseases, diabetes, and cancer. Its anti-cancer effects are examined in many types of cancer including breast, colon, lung, prostate, and pancreatic cancers and have shown promising results. Herein, the studies dealing with the antitumor roles of quercetin in osteosarcoma are reviewed in this article. We take a look into quercetin’s ability to affect proliferation, apoptosis, invasion, and chemo-resistance of the osteosarcoma cells through regulating protein expression and signaling pathways.
Literature
1.
2.
Hayden JB, Hoang BH. Osteosarcoma: basic science and clinical implications. Orthop Clin N Am. 2006;37:1–7.CrossRef
3.
4.
Kager L, Zoubek A, Dominkus M, Lang S, Bodmer N, Jundt G, et al. Osteosarcoma in very young children: experience of the Cooperative Osteosarcoma Study Group. Cancer. 2010;116:5316–24.PubMedCrossRef
5.
Casali PG, Bielack S, Abecassis N, Aro HT, Bauer S, Biagini R, et al. Bone sarcomas: ESMO-PaedCan-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018;29:iv79–95.PubMedCrossRef
6.
Czarnecka AM, Synoradzki K, Firlej W, Bartnik E, Sobczuk P, Fiedorowicz M, et al. Molecular biology of osteosarcoma. Cancers. 2020;12:2130.PubMedCentralCrossRef
7.
8.
Thomasset SC, Berry DP, Garcea G, Marczylo T, Steward WP, Gescher AJ. Dietary polyphenolic phytochemicals–promising cancer chemopreventive agents in humans? A review of their clinical properties. Int J Cancer. 2007;120:451–8.PubMedCrossRef
9.
Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol. 2007;45:2179–205.PubMedCrossRef
10.
Hirpara KV, Aggarwal P, Mukherjee AJ, Joshi N, Burman AC. Quercetin and its derivatives: synthesis, pharmacological uses with special emphasis on anti-tumor properties and prodrug with enhanced bio-availability. Anti-cancer Agents Med Chem. 2009;9:138–61.CrossRef
11.
Wang S, Yao J, Zhou B, Yang J, Chaudry MT, Wang M, et al. Bacteriostatic effect of quercetin as an antibiotic alternative in vivo and its antibacterial mechanism in vitro. J Food Prot. 2018;81:68–78.PubMedCrossRef
12.
Eid HM, Haddad PS. The antidiabetic potential of quercetin: underlying mechanisms. Curr Med Chem. 2017;24:355–64.PubMedCrossRef
13.
Lei CS, Hou YC, Pai MH, Lin MT, Yeh SL. Effects of quercetin combined with anticancer drugs on metastasis-associated factors of gastric cancer cells: in vitro and in vivo studies. J Nutr Biochem. 2018;51:105–13.PubMedCrossRef
14.
Maurya AK, Vinayak M. Quercetin regresses Dalton’s lymphoma growth via suppression of PI3K/AKT signaling leading to upregulation of p53 and decrease in energy metabolism. Nutr Cancer. 2015;67:354–63.PubMedCrossRef
15.
Darband SG, Kaviani M, Yousefi B, Sadighparvar S, Pakdel FG, Attari JA, et al. Quercetin: a functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer. J Cell Physiol. 2018;233:6544–60.PubMedCrossRef
16.
Vafadar A, Shabaninejad Z, Movahedpour A, Fallahi F, Taghavipour M, Ghasemi Y, et al. Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells. Cell Biosci. 2020;10:32.PubMedPubMedCentralCrossRef
17.
Kasiri N, Rahmati M, Ahmadi L, Eskandari N, Motedayyen H. Therapeutic potential of quercetin on human breast cancer in different dimensions. Inflammopharmacology. 2020;28:39–62.PubMedCrossRef
18.
19.
Bloom D. Congenital telangiectatic erythema resembling lupus erythematosus in dwarfs; probably a syndrome entity. AMA Am J Dis Child. 1954;88:754–8.PubMed
20.
Porter DE, Holden ST, Steel CM, Cohen BB, Wallace MR, Reid R. A significant proportion of patients with osteosarcoma may belong to Li-Fraumeni cancer families. J Bone Joint Surg Br Vol. 1992;74:883–6.CrossRef
21.
Hicks MJ, Roth JR, Kozinetz CA, Wang LL. Clinicopathologic features of osteosarcoma in patients with Rothmund–Thomson syndrome. J Clin Oncol. 2007;25:370–5.PubMedCrossRef
22.
Wang LL, Gannavarapu A, Kozinetz CA, Levy ML, Lewis RA, Chintagumpala MM, et al. Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund–Thomson syndrome. J Natl Cancer Inst. 2003;95:669–74.PubMedCrossRef
23.
24.
Matsunaga E. Hereditary retinoblastoma: host resistance and second primary tumors. J Natl Cancer Inst. 1980;65:47–51.PubMed
25.
26.
27.
Miller RW. Contrasting epidemiology of childhood osteosarcoma, Ewing’s tumor, and rhabdomyosarcoma. National Cancer Institute monograph. 1981. p. 9–15.
28.
Lonardo F, Ueda T, Huvos AG, Healey J, Ladanyi M. p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate. Cancer. 1997;79:1541–7.PubMedCrossRef
29.
Goodrich DW, Wang NP, Qian YW, Lee EY, Lee WH. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell. 1991;67:293–302.PubMedCrossRef
30.
Wadayama B, Toguchida J, Shimizu T, Ishizaki K, Sasaki MS, Kotoura Y, et al. Mutation spectrum of the retinoblastoma gene in osteosarcomas. Cancer Res. 1994;54:3042–8.PubMed
31.
Feugeas O, Guriec N, Babin-Boilletot A, Marcellin L, Simon P, Babin S, et al. Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma. J Clin Oncol. 1996;14:467–72.PubMedCrossRef
32.
Mohaghegh P, Hickson ID. DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders. Hum Mol Genet. 2001;10:741–6.PubMedCrossRef
33.
Lafleur EA, Koshkina NV, Stewart J, Jia SF, Worth LL, Duan X, et al. Increased Fas expression reduces the metastatic potential of human osteosarcoma cells. Clin Cancer Res. 2004;10:8114–9.PubMedCrossRef
34.
Worth LL, Lafleur EA, Jia SF, Kleinerman ES. Fas expression inversely correlates with metastatic potential in osteosarcoma cells. Oncol Rep. 2002;9:823–7.PubMed
35.
Kim LC, Song L, Haura EB. Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol. 2009;6:587–95.PubMedCrossRef
36.
Hingorani P, Zhang W, Gorlick R, Kolb EA. Inhibition of Src phosphorylation alters metastatic potential of osteosarcoma in vitro but not in vivo. Clin Cancer Res. 2009;15:3416–22.PubMedCrossRef
37.
He J, Zhang P, Li Q, Zhou D, Liu P. Expression of high mobility group box 1 protein predicts a poorer prognosis for patients with osteosarcoma. Oncol Lett. 2016;11:293–8.PubMedCrossRef
38.
Li Z, Xiao J, Hu K, Wang G, Li M, Zhang J, et al. FBXW7 acts as an independent prognostic marker and inhibits tumor growth in human osteosarcoma. Int J Mol Sci. 2015;16:2294–306.PubMedPubMedCentralCrossRef
39.
Gemoll T, Epping F, Heinrich L, Fritzsche B, Roblick UJ, Szymczak S, et al. Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies. Oncotarget. 2015;6:16517–26.PubMedPubMedCentralCrossRef
40.
Akatsuka T, Wada T, Kokai Y, Kawaguchi S, Isu K, Yamashiro K, et al. ErbB2 expression is correlated with increased survival of patients with osteosarcoma. Cancer. 2002;94:1397–404.PubMedCrossRef
41.
Onda M, Matsuda S, Higaki S, Iijima T, Fukushima J, Yokokura A, et al. ErbB-2 expression is correlated with poor prognosis for patients with osteosarcoma. Cancer. 1996;77:71–8.PubMedCrossRef
42.
Polednak AP. Bone cancer among female radium dial workers. Latency periods and incidence rates by time after exposure: brief communication. J Natl Cancer Inst. 1978;60:77–82.PubMedCrossRef
43.
Picci P. Osteosarcoma (osteogenic sarcoma). Orphanet J Rare Dis. 2007;2:1–4.CrossRef
44.
Longhi A, Barbieri E, Fabbri N, Macchiagodena M, Favale L, Lippo C, et al. Radiation-induced osteosarcoma arising 20 years after the treatment of Ewing’s sarcoma. Tumori. 2003;89:569–72.PubMedCrossRef
45.
Rani AS, Kumar S. Transformation of non-tumorigenic osteoblast-like human osteosarcoma cells by hexavalent chromates: alteration of morphology, induction of anchorage-independence and proteolytic function. Carcinogenesis. 1992;13:2021–7.PubMedCrossRef
46.
47.
Mazabraud A. Experimental production of bone sarcomas in the rabbit by a single local injection of beryllium. Bull Cancer. 1975;62:49–58.PubMed
48.
Tan ML, Choong PF, Dass CR, Osteosarcoma. Conventional treatment vs. gene therapy. Cancer Biol Ther. 2009;8:106–17.PubMedCrossRef
49.
50.
Yamagata K. Metabolic syndrome: preventive effects of dietary flavonoids. Stud Nat Prod Chem. 2019;60:1–28.CrossRef
51.
52.
Zhang Y, Li Y, Cao C, Cao J, Chen W, Zhang Y, et al. Dietary flavonol and flavone intakes and their major food sources in Chinese adults. Nutr Cancer. 2010;62:1120–7.PubMedCrossRef
53.
D’Andrea G, Quercetin. A flavonol with multifaceted therapeutic applications? Fitoterapia. 2015;106:256–71.PubMedCrossRef
54.
Saccol R, da Silveira KL, Manzoni AG, Abdalla FH, de Oliveira JS, Dornelles GL, et al. Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis. J Cell Biochem. 2020;121:2792–801.PubMedCrossRef
55.
Arts IC, Sesink AL, Faassen-Peters M, Hollman PC. The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides. Br J Nutr. 2004;91:841–7.PubMedCrossRef
56.
Németh K, Plumb GW, Berrin J-G, Juge N, Jacob R, Naim HY, et al. Deglycosylation by small intestinal epithelial cell β-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur J Nutr. 2003;42:29–42.PubMedCrossRef
57.
Guo Y, Bruno RS. Endogenous and exogenous mediators of quercetin bioavailability. J Nutr Biochem. 2015;26:201–10.PubMedCrossRef
58.
Khaled KA, El-Sayed YM, Al-Hadiya BM. Disposition of the flavonoid quercetin in rats after single intravenous and oral doses. Drug Dev Ind Pharm. 2003;29:397–403.PubMedCrossRef
59.
Walle T, Walle UK, Halushka PV. Carbon dioxide is the major metabolite of quercetin in humans. J Nutr. 2001;131:2648–52.PubMedCrossRef
60.
Costa LG, Garrick JM, Roquè PJ, Pellacani C. Mechanisms of neuroprotection by quercetin: counteracting oxidative stress and more. Oxid Med Cell Longev. 2016;2016:2986796.PubMedPubMedCentralCrossRef
61.
Dabeek WM, Marra MV. Dietary Quercetin and kaempferol: bioavailability and potential cardiovascular-related bioactivity in humans. Nutrients. 2019;11:2288.PubMedCentralCrossRef
62.
Habtemariam S, Belai A. Natural therapies of the inflammatory bowel disease: the case of rutin and its aglycone, quercetin. Mini Rev Med Chem. 2018;18:234–43.PubMedCrossRef
63.
Khan H, Ullah H, Aschner M, Cheang WS, Akkol EK. Neuroprotective effects of quercetin in Alzheimer’s disease. Biomolecules. 2019;10:59.PubMedCentralCrossRef
64.
Piovezana Bossolani GD, Silva BT, Colombo Martins Perles JV, Lima MM, Vieira Frez FC, de GarciaSouza SR, et al. Rheumatoid arthritis induces enteric neurodegeneration and jejunal inflammation, and quercetin promotes neuroprotective and anti-inflammatory actions. Life Sci. 2019;238:116956.PubMedCrossRef
65.
Cesarone MR, Belcaro G, Hu S, Dugall M, Hosoi M, Ledda A, et al. Supplementary prevention and management of asthma with quercetin phytosome: a pilot registry. Minerva Med. 2019;110:524–9.PubMed
66.
Abdel-Tawab MS, Mostafa Tork O, Mostafa-Hedeab G, Ewaiss Hassan M, Azmy Elberry D. Protective effects of quercetin and melatonin on indomethacin induced gastric ulcers in rats. Rep Biochem Mol Biol. 2020;9:278–90.PubMedPubMedCentralCrossRef
67.
Alkushi AGR, Elsawy NAM. Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats. Folia Morphol. 2017;76:252–61.CrossRef
68.
Chen S, Jiang H, Wu X, Fang J. Therapeutic effects of quercetin on inflammation, obesity, and type 2 diabetes. Mediat Inflamm. 2016;2016:9340637.CrossRef
69.
Ebrahimpour S, Zakeri M, Esmaeili A. Crosstalk between obesity, diabetes, and alzheimer’s disease:introducing quercetin as an effective triple herbal medicine. Ageing Res Rev. 2020;62:101095.PubMedCrossRef
70.
Reyes-Farias M, Carrasco-Pozo C. The anti-cancer effect of quercetin: molecular implications in cancer metabolism. Int J Mol Sci. 2019;20:3177.PubMedCentralCrossRef
71.
Sezer ED, Oktay LM, Karadadaş E, Memmedov H, Selvi Gunel N, Sözmen E. Assessing anticancer potential of blueberry flavonoids, quercetin, kaempferol, and gentisic acid, through oxidative stress and apoptosis parameters on HCT-116 cells. J Med Food. 2019;22:1118–26.PubMedCrossRef
72.
Tang SM, Deng XT, Zhou J, Li QP, Ge XX, Miao L. Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects. Biomed Pharmacother = Biomedecine & Pharmacotherapie. 2020;121:109604.CrossRef
73.
Cebecioglu R, Yildirim M, Akagunduz D, Korkmaz I, Tekin HO, Atasever-Arslan B, et al. Synergistic effects of quercetin and selenium on oxidative stress in endometrial adenocarcinoma cells. Bratislavske lekarske listy. 2019;120:449–55.PubMed
74.
Hashemzaei M, Delarami Far A, Yari A, Heravi RE, Tabrizian K, Taghdisi SM, et al. Anticancer and apoptosis—inducing effects of quercetin in vitro and in vivo. Oncol Rep. 2017;38:819–28.PubMedPubMedCentralCrossRef
75.
Dong Y, Yang J, Yang L, Li P. Quercetin inhibits the proliferation and metastasis of human non-small cell lung cancer cell line: the key role of Src-mediated fibroblast growth factor-inducible 14 (Fn14)/nuclear factor kappa B (NF-κB) pathway. Med Sci Monit. 2020;26:e920537.PubMedPubMedCentralCrossRef
76.
Ren KW, Li YH, Wu G, Ren JZ, Lu HB, Li ZM, et al. Quercetin nanoparticles display antitumor activity via proliferation inhibition and apoptosis induction in liver cancer cells. Int J Oncol. 2017;50:1299–311.PubMedCrossRef
77.
Srivastava NS, Srivastava RAK. Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells and modulate Wnt/β-catenin signaling and apoptotic pathways in A375 cells. Phytomedicine. 2019;52:117–28.PubMedCrossRef
78.
Chen KC, Hsu WH, Ho JY, Lin CW, Chu CY, Kandaswami CC, et al. Flavonoids luteolin and quercetin inhibit RPS19 and contributes to metastasis of cancer cells through c-Myc reduction. J Food Drug Anal. 2018;26:1180–91.PubMedCrossRef
79.
Lee YH, Tuyet PT. Synthesis and biological evaluation of quercetin-zinc (II) complex for anti-cancer and anti-metastasis of human bladder cancer cells. In Vitro Cell Dev Biol Anim. 2019;55:395–404.PubMedCrossRef
80.
Yu D, Ye T, Xiang Y, Shi Z, Zhang J, Lou B, et al. Quercetin inhibits epithelial–mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial-mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells. OncoTargets Ther. 2017;10:4719–29.CrossRef
81.
Zhao X, Zhang J. Mechanisms for quercetin in prevention of lung cancer cell growth and metastasis. Zhong nan da xue xue bao Yi xue ban = J Cent South Univ Med Sci. 2015;40:592–7.
82.
Hussain Y, Mirzaei S, Ashrafizadeh M, Zarrabi A, Hushmandi K, Khan H, et al. Quercetin and its nano-scale delivery systems in prostate cancer therapy: paving the way for cancer elimination and reversing chemoresistance. Cancers. 2021;13:1602.PubMedPubMedCentralCrossRef
83.
Jaganathan SK. Can flavonoids from honey alter multidrug resistance? Med Hypotheses. 2011;76:535–7.PubMedCrossRef
84.
Lu X, Yang F, Chen D, Zhao Q, Chen D, Ping H, et al. Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways. Int J Biol Sci. 2020;16:1121–34.PubMedPubMedCentralCrossRef
85.
Lan CY, Chen SY, Kuo CW, Lu CC, Yen GC. Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells. J Food Drug Anal. 2019;27:887–96.PubMedCrossRef
86.
Alban L, Monteiro WF, Diz FM, Miranda GM, Scheid CM, Zotti ER, et al. New quercetin-coated titanate nanotubes and their radiosensitization effect on human bladder cancer. Mater Sci Eng C Mater Biol Appl. 2020;110:110662.PubMedCrossRef
87.
Li Y, Wang Z, Jin J, Zhu SX, He GQ, Li SH, et al. Quercetin pretreatment enhances the radiosensitivity of colon cancer cells by targeting Notch-1 pathway. Biochem Biophys Res Commun. 2020;523:947–53.PubMedCrossRef
88.
Ryu S, Park S, Lim W, Song G. Quercetin augments apoptosis of canine osteosarcoma cells by disrupting mitochondria membrane potential and regulating PKB and MAPK signal transduction. J Cell Biochem. 2019;120:17449–58.PubMedCrossRef
89.
Song L. Relationship between the induction of heat shock proteins and the decrease in glucocorticoid receptor during heat shock response in human osteosarcoma cells. Sci China B Chem Life Sci Earth Sci. 1995;38:1473–81.
90.
Berndt K, Campanile C, Muff R, Strehler E, Born W, Fuchs B. Evaluation of quercetin as a potential drug in osteosarcoma treatment. Anticancer Res. 2013;33:1297–306.PubMed
91.
Lan H, Hong W, Fan P, Qian D, Zhu J, Bai B. Quercetin inhibits cell migration and invasion in human osteosarcoma cells. Cell Physiol Biochem. 2017;43:553–67.PubMedCrossRef
92.
Li S, Pei Y, Wang W, Liu F, Zheng K, Zhang X. Quercetin suppresses the proliferation and metastasis of metastatic osteosarcoma cells by inhibiting parathyroid hormone receptor 1. Biomed Pharmacother = Biomedecine & Pharmacotherapie. 2019;114:108839.CrossRef
93.
Liang W, Li X, Li C, Liao L, Gao B, Gan H, et al. Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. Mol Med Rep. 2011;4:1017–23.PubMed
94.
Xie X, Yin J, Jia Q, Wang J, Zou C, Brewer KJ, et al. Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. Oncol Rep. 2011;26:687–93.PubMed
95.
Yin J, Xie X, Jia Q, Wang J, Huang G, Zou C, et al. Effect and mechanism of quercetin on proliferation and apoptosis of human osteosarcoma cell U-2OS/MTX300. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China J Chin Mater Med. 2012;37:611–4.
96.
Suh DK, Lee EJ, Kim HC, Kim JH. Induction of G(1)/S phase arrest and apoptosis by quercetin in human osteosarcoma cells. Arch Pharm Res. 2010;33:781–5.PubMedCrossRef
97.
Wu B, Zeng W, Ouyang W, Xu Q, Chen J, Wang B, et al. Quercetin induced NUPR1-dependent autophagic cell death by disturbing reactive oxygen species homeostasis in osteosarcoma cells. J Clin Biochem Nutr. 2020;67:137–45.PubMedPubMedCentralCrossRef
98.
Zhang X, Guo Q, Chen J, Chen Z. Quercetin enhances cisplatin sensitivity of human osteosarcoma cells by modulating microRNA-217-KRAS axis. Mol Cells. 2015;38:638–42.PubMedPubMedCentralCrossRef
99.
Catanzaro D, Ragazzi E, Vianello C, Caparrotta L, Montopoli M. Effect of quercetin on cell cycle and cyclin expression in ovarian carcinoma and osteosarcoma cell lines. Nat Prod Commun. 2015;10:1365–8.PubMed
Metadata
Title
Anti-cancer properties of quercetin in osteosarcoma
Authors
Parisa Maleki Dana
Fatemeh Sadoughi
Zatollah Asemi
Bahman Yousefi
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2021
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-021-02067-8

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