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Cancer Cell International
Published in: Cancer Cell International 1/2022

Open Access 01-12-2022 | osteosarcoma | Review

A review on the role of DANCR in the carcinogenesis

Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Aria Baniahmad, Mohammad Taheri, Mohammad Samadian

Published in: Cancer Cell International | Issue 1/2022

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Abstract

DANCR is an RNA gene located on chr4. This gene has several splice variants. Up-regulation of DANCR has been reported in many types of cancers. This lncRNA is mainly located in the cytoplasm and regulates genes expression at post-transcriptional level. In fact, it acts as a molecular sponge for a variety of miRNAs, including miR-874-3P, miR-335, miR-149, miR-4319, miR-758-3p, miR-216a-5p, miR-874-3p, miR-33a-5p, miR-335-5p, miR-145-3p, miR-665, miR-345-5p and miR-125b-5p. DANCR also regulates activity of PI3K/AKT/NF-κB, Wnt/β-catenin, ERK/SMAD, MAPK, IL-6/JAK1/STAT3, Smad2/3, p53, FAK/PI3K/AKT/GSK3β/Snail pathways. In the current narrative review article, we summarize the roles of DANCR in the carcinogenesis, with an especial emphasis on its role in the development of osteosarcoma and lung, liver, pancreatic and colorectal cancers.
Literature
1.
Thin KZ, Liu X, Feng X, Raveendran S, Tu JC. LncRNA-DANCR: a valuable cancer related long non-coding RNA for human cancers. Pathol Res Pract. 2018;214(6):801–5 (Epub 2018/05/08).PubMedCrossRef
2.
Jiang N, Wang X, Xie X, Liao Y, Liu N, Liu J, et al. lncRNA DANCR promotes tumor progression and cancer stemness features in osteosarcoma by upregulating AXL via miR-33a-5p inhibition. Cancer Lett. 2017;405:46–55.PubMedCrossRef
3.
Wang Y, Zeng X, Wang N, Zhao W, Zhang X, Teng S, et al. Long noncoding RNA DANCR, working as a competitive endogenous RNA, promotes ROCK1-mediated proliferation and metastasis via decoying of miR-335-5p and miR-1972 in osteosarcoma. Mol Cancer. 2018;17(1):1–14.CrossRef
4.
Zhang W, Li J, Tai Q, Tang J, Huang Y, Gao S. LncRNA DANCR regulates osteosarcoma migration and invasion by targeting miR-149/MSI2 axis. Eur Rev Med Pharmacol Sci. 2020;24(12):6551–60.PubMed
5.
Shao C, Liu G, Zhang X, Li A, Guo X. Long noncoding RNA RMRP suppresses the tumorigenesis of hepatocellular carcinoma through targeting microRNA-766. Onco Targets Ther. 2020;13:3013.PubMedPubMedCentralCrossRef
6.
Zhou X, Yang Y, Li Y, Liang G, Kang D, Zhou B, et al. METTL3 contributes to osteosarcoma progression by increasing DANCR mRNA stability via m6A modification. Front Cell Dev Biol. 2021;9:784719.PubMedCrossRef
7.
Ping Q, Shi Y, Yang M, Li H, Zhong Y, Li J, et al. LncRNA DANCR regulates lymphatic metastasis of bladder cancer via the miR-335/VEGF-C axis. Transl Androl Urol. 2021;10(4):1743.PubMedPubMedCentralCrossRef
8.
Chen Z, Chen X, Xie R, Huang M, Dong W, Han J, et al. DANCR promotes metastasis and proliferation in bladder cancer cells by enhancing IL-11-STAT3 signaling and CCND1 expression. Mol Ther. 2019;27(2):326–41.PubMedPubMedCentralCrossRef
9.
Zhan Y, Chen Z, Li Y, He A, He S, Gong Y, et al. Long non-coding RNA DANCR promotes malignant phenotypes of bladder cancer cells by modulating the miR-149/MSI2 axis as a ceRNA. J Exp Clin Cancer Res. 2018;37(1):1–12.CrossRef
10.
Zhen Q, Gao L-N, Wang R-F, Chu W-W, Zhang Y-X, Zhao X-J, et al. LncRNA DANCR promotes lung cancer by sequestering miR-216a. Cancer Control. 2018;25(1):1073274818769849.PubMedPubMedCentralCrossRef
11.
Huang Y, Zhang Y, Fu X. Long non-coding RNA DANCR promoted non-small cell lung cancer cells metastasis via modulating of miR-1225-3p/ErbB2 signal. Eur Rev Med Pharmacol Sci. 2021;25(2):758–69.PubMed
12.
Lu Q, Rui Z, Guo Z, Xie W, Shan S, Ren T. Lnc RNA-DANCR contributes to lung adenocarcinoma progression by sponging miR-496 to modulate mTOR expression. J Cell Mol Med. 2018;22(3):1527–37.PubMedCrossRef
13.
Chen YR, Wu YS, Wang WS, Zhang JS, Wu QG. Upregulation of lncRNA DANCR functions as an oncogenic role in non-small lung cancer by regulating miR-214–5p/CIZ1 axis. Eur Rev Med Pharmacol Sci. 2020;24(5):2539–47 (Epub 2020/03/21).PubMed
14.
Yu JE, Ju JA, Musacchio N, Mathias TJ, Vitolo MI. Long Noncoding RNA DANCR activates Wnt/β-catenin signaling through MiR-216a inhibition in non-small cell lung cancer. Biomolecules. 2020;10(12):1646 (Epub 2020/12/12).PubMedCentralCrossRef
15.
Yang L, Jiang M-N, Liu Y, Wu C-Q, Liu H. Crosstalk between lncRNA DANCR and miR-125b-5p in HCC cell progression. Tumori J. 2021;107(6):504–13.CrossRef
16.
Wang J, Pu J, Zhang Y, Yao T, Luo Z, Li W, et al. DANCR contributed to hepatocellular carcinoma malignancy via sponging miR-216a-5p and modulating KLF12. J Cell Physiol. 2019;234(6):9408–16.PubMedCrossRef
17.
Wang X, Cheng M, Gong Y, Ma W, Li B, Jiang Y. LncRNA DANCR promotes ATG7 expression to accelerate hepatocellular carcinoma cell proliferation and autophagy by sponging miR-222-3p. Eur Rev Med Pharmacol Sci. 2020;24(17):8778–87.PubMed
18.
Liu Y, Chen L, Yuan H, Guo S, Wu G. LncRNA DANCR promotes sorafenib resistance via activation of IL-6/STAT3 signaling in hepatocellular carcinoma cells. Onco Targets Ther. 2020;13:1145.PubMedPubMedCentralCrossRef
19.
Yuan S, Wang J, Yang F, Tao Q, Zhang J, Wang L, et al. Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1. Hepatology. 2016;63(2):499–511.PubMedCrossRef
20.
Guo D, Li Y, Chen Y, Zhang D, Wang X, Lu G, et al. DANCR promotes HCC progression and regulates EMT by sponging miR-27a-3p via ROCK1/LIMK1/COFILIN1 pathway. Cell Prolif. 2019;52(4):e12628.PubMedPubMedCentralCrossRef
21.
Shi H, Li K, Feng J, Liu G, Feng Y, Zhang X. LncRNA-DANCR interferes with miR-125b-5p/HK2 axis to desensitize colon cancer cells to cisplatin vis activating anaerobic glycolysis. Front Oncol. 2020;10:1034.PubMedPubMedCentralCrossRef
22.
Sun Y, Cao B, Zhou J. Roles of DANCR/microRNA-518a-3p/MDMA ceRNA network in the growth and malignant behaviors of colon cancer cells. BMC Cancer. 2020;20(1):1–13.CrossRef
23.
Xiong M, Wu M, Peng D, Huang W, Chen Z, Ke H, et al. LncRNA DANCR represses doxorubicin-induced apoptosis through stabilizing MALAT1 expression in colorectal cancer cells. Cell Death Dis. 2021;12(1):1–17.CrossRef
24.
Luo Y, Wang Q, Teng L, Zhang J, Song J, Bo W, et al. LncRNA DANCR promotes proliferation and metastasis in pancreatic cancer by regulating miRNA-33b. FEBS Open Bio. 2020;10(1):18–27.PubMedCrossRef
25.
Yao Z, Chen Q, Ni Z, Zhou L, Wang Y, Yang Y, et al. Long non-coding RNA differentiation antagonizing nonprotein coding RNA (DANCR) promotes proliferation and invasion of pancreatic cancer by sponging miR-214-5p to regulate E2F2 expression. Med Sci Monit Int Med J Exper Clin Res. 2019;25:4544.
26.
Tang Y, Cao G, Zhao G, Wang C, Qin Q. LncRNA differentiation antagonizing non-protein coding RNA promotes proliferation and invasion through regulating miR-135a/NLRP37 axis in pancreatic cancer. Invest New Drugs. 2020;38(3):714–21.PubMedCrossRef
27.
Tang J, Zhong G, Zhang H, Yu B, Wei F, Luo L, et al. LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA. Cell Death Dis. 2018;9(12):1–12.CrossRef
28.
29.
Zhang KJ, Tan XL, Guo L. The long non-coding RNA DANCR regulates the inflammatory phenotype of breast cancer cells and promotes breast cancer progression via EZH2-dependent suppression of SOCS3 transcription. Mol Oncol. 2020;14(2):309–28.PubMedPubMedCentralCrossRef
30.
Xu Y, Shang J, Li M, Zhang Y. LncRNA DANCR accelerates the development of multidrug resistance of gastric cancer. Eur Rev Med Pharmacol Sci. 2019;23(7):2794–802.PubMed
31.
Cheng Z, Liu G, Huang C, Zhao X. KLF5 activates lncRNA DANCR and inhibits cancer cell autophagy accelerating gastric cancer progression. NPJ Genom Med. 2021;6(1):1–10.CrossRef
32.
Pan L, Liang W, Gu J, Zang X, Huang Z, Shi H, et al. Long noncoding RNA DANCR is activated by SALL4 and promotes the proliferation and invasion of gastric cancer cells. Oncotarget. 2018;9(2):1915.PubMedCrossRef
33.
Zhang H, Liu L, Chen L, Liu H, Ren S, Tao Y. Long noncoding RNA DANCR confers cytarabine resistance in acute myeloid leukemia by activating autophagy via the miR-874-3P/ATG16L1 axis. Mol Oncol. 2021;15(4):1203–16.PubMedPubMedCentralCrossRef
34.
Li Y-L, Wang X-M, Qiao G-D, Zhang S, Wang J, Cong Y-Z, et al. Up-regulated lnc-lung cancer associated transcript 1 enhances cell migration and invasion in breast cancer progression. Biochem Biophys Res Commun. 2020;521(2):271–8.PubMedCrossRef
35.
Tao W, Wang C, Zhu B, Zhang G, Pang D. LncRNA DANCR contributes to tumor progression via targetting miR-216a-5p in breast cancer: lncRNA DANCR contributes to tumor progression. Biosci Rep. 2019;39(4):BSR20181618.PubMedPubMedCentralCrossRef
36.
Wu G, Zhou H, Li D, Zhi Y, Liu Y, Li J, et al. LncRNA DANCR upregulation induced by TUFT1 promotes malignant progression in triple negative breast cancer via miR-874-3p-SOX2 axis. Exp Cell Res. 2020;396(2):112331.PubMedCrossRef
37.
Sha S, Yuan D, Liu Y, Han B, Zhong N. Targeting long non-coding RNA DANCR inhibits triple negative breast cancer progression. Biol Open. 2017;6(9):1310–6.PubMedPubMedCentral
38.
Vaidya AM, Sun Z, Ayat N, Schilb A, Liu X, Jiang H, et al. Systemic delivery of tumor-targeting siRNA nanoparticles against an oncogenic LncRNA facilitates effective triple-negative breast cancer therapy. Bioconjug Chem. 2019;30(3):907–19.PubMedPubMedCentralCrossRef
39.
Liang H, Zhang C, Guan H, Liu J, Cui Y. LncRNA DANCR promotes cervical cancer progression by upregulating ROCK1 via sponging miR-335–5p. J Cell Physiol. 2019;234(5):7266–78 (Epub 2018/10/27).PubMedCrossRef
40.
Tian W, Lei N, Guo R, Yuan Z, Chang L. Long non-coding RNA DANCR promotes cervical cancer growth via activation of the Wnt/β-catenin signaling pathway. Cancer Cell Int. 2020;20(1):1–12.CrossRef
41.
Hu C, Han Y, Zhu G, Li G, Wu X. Krüppel-like factor 5-induced overexpression of long non-coding RNA DANCR promotes the progression of cervical cancer via repressing microRNA-145-3p to target ZEB1. Cell Cycle. 2021;20(14):1441–54.PubMedCrossRef
42.
Cao L, Jin H, Zheng Y, Mao Y, Fu Z, Li X, et al. DANCR-mediated microRNA-665 regulates proliferation and metastasis of cervical cancer through the ERK/SMAD pathway. Cancer Sci. 2019;110(3):913–25.PubMedPubMedCentralCrossRef
43.
Zhu C, Fan C, Zhang Y, Sun Q, Yan M, Wei W, et al. LncRNA DANCR affected cell growth, EMT and angiogenesis by sponging miR-345-5p through modulating Twist1 in cholangiocarcinoma. Eur Rev Med Pharmacol Sci. 2020;24(5):2321–34.PubMed
44.
Wang N, Zhang C, Wang W, Liu J, Yu Y, Li Y, et al. Long noncoding RNA DANCR regulates proliferation and migration by epigenetically silencing FBP1 in tumorigenesis of cholangiocarcinoma. Cell Death Dis. 2019;10(8):1–11.CrossRef
45.
Yang XJ, Zhao JJ, Chen WJ, Zhang GG, Wang W, Tao HC. Silencing long non-coding RNA, differentiation antagonizing non-protein coding RNA promotes apoptosis and inhibits tumor growth in colon cancer. Oncol Lett. 2018;16(3):2865–72.PubMedPubMedCentral
46.
47.
Lian J, Zhang H, Wei F, Li Q, Lu Y, Yu B, et al. Long non-coding RNA DANCR promotes colorectal tumor growth by binding to lysine acetyltransferase 6A. Cell Signal. 2020;67:109502.PubMedCrossRef
48.
Bahreini F, Saidijam M, Mousivand Z, Najafi R, Afshar S. Assessment of lncRNA DANCR, miR-145-5p and NRAS axis as biomarkers for the diagnosis of colorectal cancer. Mol Biol Rep. 2021;48(4):3541–7.PubMedCrossRef
49.
Fang Y, Chen S, Liu Z, Ai W, He X, Wang L, et al. Endothelial stem cells attenuate cardiac apoptosis via downregulating cardiac microRNA-146a in a rat model of coronary heart disease. Exp Ther Med. 2018;16(5):4246–52.PubMedPubMedCentral
50.
Sun J, Gao S, Lu C. Knockdown of differentiation antagonizing non-protein coding RNA exerts anti-tumor effect by up-regulating miR-214 in endometrial carcinoma. Mol Cell Biochem. 2019;460(1):9–15.PubMedCrossRef
51.
Bi Y, Guo S, Xu X, Kong P, Cui H, Yan T, et al. Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinoma. Cell Death Dis. 2020;11(4):1–17.CrossRef
52.
Zhang C, Wang L, Yang J, Fu Y, Li H, Xie L, et al. MicroRNA-33a-5p suppresses esophageal squamous cell carcinoma progression via regulation of lncRNA DANCR and ZEB1. Eur J Pharmacol. 2019;861:172590.PubMedCrossRef
53.
Shi H, Shi J, Zhang Y, Guan C, Zhu J, Wang F, et al. Long non-coding RNA DANCR promotes cell proliferation, migration, invasion and resistance to apoptosis in esophageal cancer. J Thorac Dis. 2018;10(5):2573.PubMedPubMedCentralCrossRef
54.
Hao Y-P, Qiu J-H, Zhang D-B, Yu C-G. Long non-coding RNA DANCR, a prognostic indicator, promotes cell growth and tumorigenicity in gastric cancer. Tumor Biol. 2017;39(6):1010428317699798.CrossRef
55.
Feng L, Lin T, Che H, Wang X. Long noncoding RNA DANCR knockdown inhibits proliferation, migration and invasion of glioma by regulating miR-135a-5p/BMI1. Cancer Cell Int. 2020;20(1):1–13.CrossRef
56.
Yang J, Sun Y, Gao L, Meng Q, Yang B. Long non-coding RNA DANCR facilitates glioma malignancy by sponging miR-33a-5p. Neoplasma. 2018;65(5):790–8.PubMedCrossRef
57.
Li J, Zhou L. Overexpression of lncRNA DANCR positively affects progression of glioma via activating Wnt/β-catenin signaling. Biomed Pharmacother. 2018;102:602–7.PubMedCrossRef
58.
Ma Y, Zhou G, Li M, Hu D, Zhang L, Liu P, et al. Long noncoding RNA DANCR mediates cisplatin resistance in glioma cells via activating AXL/PI3K/Akt/NF-κB signaling pathway. Neurochem Int. 2018;118:233–41.PubMedCrossRef
59.
Xu D, Yu J, Gao G, Lu G, Zhang Y, Ma P. LncRNA DANCR functions as a competing endogenous RNA to regulate RAB1A expression by sponging miR-634 in glioma. Biosci Rep. 2018;38(1):BSR20171664.PubMedPubMedCentralCrossRef
60.
Wang W, Li Y, Ma Q, Yan H, Su W. Differentiation antagonizing non-protein coding RNA modulates the proliferation, migration, and angiogenesis of glioma cells by targeting the miR-216a/LGR5 axis and the PI3K/AKT signaling pathway. Onco Targets Ther. 2019;12:2439.PubMedPubMedCentralCrossRef
61.
Han J, Yu X, Wang S, Wang Y, Liu Q, Xu H, et al. IGF2BP2 induces U251 glioblastoma cell chemoresistance by inhibiting FOXO1-mediated PID1 expression through stabilizing lncRNA DANCR. Front Cell Dev Biol. 2021;9:659228.PubMedCrossRef
62.
Ma X, Wang X, Yang C, Wang Z, Han B, Wu L, et al. DANCR acts as a diagnostic biomarker and promotes tumor growth and metastasis in hepatocellular carcinoma. Anticancer Res. 2016;36(12):6389–98.PubMedCrossRef
63.
Zhang N, Jiang W. Long non-coding RNA DANCR promotes HMGA2-mediated invasion in lung adenocarcinoma cells. Oncol Rep. 2019;41(2):1083–90.PubMed
64.
Guo L, Gu J, Hou S, Liu D, Zhou M, Hua T, et al. Long non-coding RNA DANCR promotes the progression of non-small-cell lung cancer by inhibiting p21 expression. Onco Targets Ther. 2019;12:135.PubMedCrossRef
65.
Bai Y, Zhang G, Chu H, Li P, Li J. The positive feedback loop of lncRNA DANCR/miR-138/Sox4 facilitates malignancy in non-small cell lung cancer. Am J Cancer Res. 2019;9(2):270.PubMedPubMedCentral
66.
Wang S, Jiang M. The long non-coding RNA-DANCR exerts oncogenic functions in non-small cell lung cancer via miR-758-3p. Biomed Pharmacother. 2018;103:94–100.PubMedCrossRef
67.
Wang B, Chen W, Zhao Z, Sun Y, Huang Y. LncRNA-DANCR promotes growth and metastasis of colorectal cancer via activating epithelial-mesenchymal transition process. Transl Cancer Res. 2019;8(7):2517.PubMedPubMedCentralCrossRef
68.
Wu L, Xia L, Jiang H, Hu Y, Li L, Xu L, et al. Long non-coding RNA DANCR represses the viability, migration and invasion of multiple myeloma cells by sponging miR-135b-5p to target KLF9. Mol Med Rep. 2021;24(3):1–12.CrossRef
69.
Jia X, Shi L, Wang X, Luo L, Ling L, Yin J, et al. KLF5 regulated lncRNA RP1 promotes the growth and metastasis of breast cancer via repressing p27kip1 translation. Cell Death Dis. 2019;10(5):1–16.CrossRef
70.
Li Q, Jiang Y, Zhong G, Lu Y, Song T, Zhang Y, et al. Long noncoding RNA DANCR regulates cell proliferation by stabilizing SOX2 mRNA in nasopharyngeal carcinoma. Am J Pathol. 2020;190(12):2343–54.PubMedCrossRef
71.
Hao Y, Zhao H, Jin X, He P, Zhang J, Dong Q, et al. Long non-coding RNA DANCR promotes nasopharyngeal carcinoma cell proliferation and migration. Mol Med Rep. 2019;19(4):2883–9.PubMed
72.
Zhang J, Jin X, Zhou C, Zhao H, He P, Hao Y, et al. Resveratrol suppresses human nasopharyngeal carcinoma cell growth via inhibiting differentiation antagonizing non-protein coding RNA (DANCR) expression. Med Sci Monit Int Med J Exp Clin Res. 2020;26:e923622–31.
73.
Wen X, Liu X, Mao Y-P, Yang X-J, Wang Y-Q, Zhang P-P, et al. Long non-coding RNA DANCR stabilizes HIF-1α and promotes metastasis by interacting with NF90/NF45 complex in nasopharyngeal carcinoma. Theranostics. 2018;8(20):5676.PubMedPubMedCentralCrossRef
74.
Bi C, Shan J, Li M, Zhang Q, Li C, Tong J, et al. Long noncoding RNA differentiation antagonizing nonprotein coding RNA promotes the proliferation, invasion and migration of neuroblastoma cells via targeting β-1, 4-galactosyltransferase III by sponging miR-338-3p. NeuroReport. 2021;32(12):965–74.PubMedCrossRef
75.
Qu X-H, Shi Y-L, Ma Y, Bao W-W, Yang L, Li J-C, et al. LncRNA DANCR regulates the growth and metastasis of oral squamous cell carcinoma cells via altering miR-216a-5p expression. Hum Cell. 2020;33(4):1281–93.PubMedCrossRef
76.
Cui PH, Li ZY, Li DH, Han SY, Zhang YJ. SP1-induced lncRNA DANCR contributes to proliferation and invasion of ovarian cancer. Kaohsiung J Med Sci. 2021;37(5):371–8.PubMedCrossRef
77.
Huang P, Qi B, Yao H, Zhang L, Li Y, Li Q. Knockdown of DANCR suppressed the biological behaviors of ovarian cancer cells treated with transforming growth factor-β (TGF-β) by sponging MiR-214. Med Sci Monit Int Med J Exp Clin Res. 2020;26:e922760–1.
78.
Lin X, Yang F, Qi X, Li Q, Wang D, Yi T, et al. LncRNA DANCR promotes tumor growth and angiogenesis in ovarian cancer through direct targeting of miR-145. Mol Carcinog. 2019;58(12):2286–96.PubMedCrossRef
79.
Pei C, Fei K, Yuan X, Gong X. LncRNA DANCR aggravates the progression of ovarian cancer by downregulating UPF1. Eur Rev Med Pharmacol Sci. 2019;23(24):10657–63.PubMed
80.
Chen L, Liu J, Tang T, Zhang Y-C, Liu M-Z, Xu L-Y, et al. lncRNA differentiation antagonizing nonprotein coding RNA overexpression accelerates progression and indicates poor prognosis in pancreatic ductal adenocarcinoma. Onco Targets Ther. 2018;11:7955.PubMedPubMedCentralCrossRef
81.
Zhao H, Zhang Z, Shi B, Jiang X. DANCR sponges miR-135a to regulate paclitaxel sensitivity in prostate cancer. Eur Rev Med Pharmacol Sci. 2019;23(16):6849–57.PubMed
82.
Sun W, Zu S, Shao G, Wang W, Gong F. Long non-coding DANCR targets miR-185-5p to upregulate LIM and SH3 protein 1 promoting prostate cancer via the FAK/PI3K/AKT/GSK3β/snail pathway. J Gene Med. 2021;23(7):e3344.PubMedCrossRef
83.
Deng H, Zhu B, Dong Z, Jiang H, Zhao X, Wu S. miR-214-5p targeted by LncRNA DANCR mediates TGF-β signaling pathway to accelerate proliferation, migration and inhibit apoptosis of prostate cancer cells. Am J Transl Res. 2021;13(4):2224.PubMedPubMedCentral
84.
Ma Y, Fan B, Ren Z, Liu B, Wang Y. Long noncoding RNA DANCR contributes to docetaxel resistance in prostate cancer through targeting the miR-34a-5p/JAG1 pathway. Onco Targets Ther. 2019;12:5485.PubMedPubMedCentralCrossRef
85.
Jia J, Li F, Tang X-S, Xu S, Gao Y, Shi Q, et al. Long noncoding RNA DANCR promotes invasion of prostate cancer through epigenetically silencing expression of TIMP2/3. Oncotarget. 2016;7(25):37868.PubMedPubMedCentralCrossRef
86.
Jin L, Fu H, Quan J, Pan X, He T, Hu J, et al. Overexpression of long non-coding RNA differentiation antagonizing non-protein coding RNA inhibits the proliferation, migration and invasion and promotes apoptosis of renal cell carcinoma. Mol Med Rep. 2017;16(4):4463–8.PubMedCrossRef
87.
Wang JX, Yang Y, Li K. Long noncoding RNA DANCR aggravates retinoblastoma through miR-34c and miR-613 by targeting MMP-9. J Cell Physiol. 2018;233(10):6986–95.PubMedCrossRef
88.
Zheng Y, Zheng B, Meng X, Yan Y, He J, Liu Y. LncRNA DANCR promotes the proliferation, migration, and invasion of tongue squamous cell carcinoma cells through miR-135a-5p/KLF8 axis. Cancer Cell Int. 2019;19(1):1–14.CrossRef
89.
Liu Y, Li J, Yue B, Liang L, Zhang S, Chen Y. Long non-coding RNA DANCR regulate MLL3 and thereby it determines the progression of pancreatic cancer. J BUON. 2020;25:1954–9.PubMed
90.
Shi W, Jin X, Wang Y, Zhang Q, Yang L. High serum exosomal long non-coding RNA DANCR expression confers poor prognosis in patients with breast cancer. J Clin Lab Anal. 2022;36:e24186.PubMedPubMedCentralCrossRef
91.
Zhang K, Lv J, Peng X, Liu J, Li C, Li J, et al. Down-regulation of DANCR acts as a potential biomarker for papillary thyroid cancer diagnosis. Biosci Rep. 2019;39(4):BSR20181616.PubMedPubMedCentralCrossRef
92.
Mu X, Chen W, Shi J, Li X, Wang Y. Development of a GeXP-based multiplex RT-PCR assay for detection of long noncoding RNA in hepatocellular carcinoma. Lab Med. 2019;50(2):180–8.PubMedCrossRef
93.
94.
Tuluhong D, Dunzhu W, Wang J, Chen T, Li H, Li Q, et al. Prognostic value of differentially expressed LncRNAs in triple-negative breast cancer: a systematic review and meta-analysis. Crit Rev Eukaryot Gene Expr. 2020;30(5):447–56.PubMedCrossRef
95.
Shen X, Xue Y, Cong H, Wang X, Fan Z, Cui X, et al. Circulating lncRNA DANCR as a potential auxillary biomarker for the diagnosis and prognostic prediction of colorectal cancer. Biosci Rep. 2020;40(3):BSR20191481.PubMedPubMedCentralCrossRef
96.
Liu Y, Zhang M, Liang L, Li J, Chen Y-X. Over-expression of lncRNA DANCR is associated with advanced tumor progression and poor prognosis in patients with colorectal cancer. Int J Clin Exp Pathol. 2015;8(9):11480.PubMedPubMedCentral
97.
Icduygu FM, Akgun E, Sengul D, Ozgoz A, Alp E. Expression of SOX2OT, DANCR and TINCR long non-coding RNAs in papillary thyroid cancer and its effects on clinicopathological features. Mol Med Rep. 2022;25(4):1–10.CrossRef
Metadata
Title
A review on the role of DANCR in the carcinogenesis
Authors
Soudeh Ghafouri-Fard
Tayyebeh Khoshbakht
Bashdar Mahmud Hussen
Aria Baniahmad
Mohammad Taheri
Mohammad Samadian
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2022
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-022-02612-z

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