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Published in: Archives of Osteoporosis 1/2023

01-12-2023 | Osteoporosis | Original Article

Mortality following fragility hip fracture in China: a record linkage study

Authors: Yiwen Hua, Ying Li, Jiachen Zhou, Lijun Fan, Feng Huang, Zhanpo Wu, Hui Xue, Bingquan Yang, Ping Chen, Yunfeng Rui, Yong Tian, Alireza Moayyeri, Cesar Libanati, Wei Du

Published in: Archives of Osteoporosis | Issue 1/2023

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Abstract

Summary

Mortality risk declined over time. Patients with fragility hip fracture experienced an approximate ninefold excess mortality, peaking shortly after fracture, in comparison with that of the general population. Continuous efforts in lowering the occurrence of hip fracture have the potential to improve the survival of the elderly population in China.

Purpose

Hip fractures in older adults often lead to an elevated risk of death. However, few studies investigated mortality risk following hip fracture in mainland China. This retrospective cohort study aimed to evaluate the crude mortality and excess mortality after fragility hip fractures in Lishui residents aged 50 years and older.

Methods

Patients having a fragility hip fracture between October 2013 and August 2019 were identified from the Lishui District Inpatient Data Collection and followed up until August 2020. Death information was ascertained from the linked death registry records. We calculated the follow-up mortality rate and corresponding 95% confidence intervals (CIs) as well as the standard mortality ratios (SMRs) in comparison with the mortality rates of Lishui residents.

Results

During the study period, a total of 808 patients (63.4% females) with an average age of 75 years were admitted for fragility hip fractures. The 1st, 2nd, and 3rd year follow-up mortality rates were 16.51, 6.06, and 5.03 per 100 person-year, respectively. The SMRs were 8.46 (6.94, 9.97), 5.74 (4.86, 6.63), and 4.63 (3.98, 5.27) for the 1st, 2nd, and 3rd year following fragility hip fracture.

Conclusion

Although mortality risk declined over time, patients with fragility hip fracture experienced an approximate ninefold excess mortality, peaking shortly after fracture, in comparison with that of the general population. Continuous efforts in lowering the occurrence of hip fracture have the potential to improve the survival of the elderly population in China.
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Literature
2.
go back to reference Rupp M, Walter N, Pfeifer C et al (2021) The incidence of fractures among the adult population of Germany–an analysis from 2009 through 2019. Dtsch Arztebl Int 118:665–669PubMedPubMedCentral Rupp M, Walter N, Pfeifer C et al (2021) The incidence of fractures among the adult population of Germany–an analysis from 2009 through 2019. Dtsch Arztebl Int 118:665–669PubMedPubMedCentral
3.
go back to reference Clynes MA, Harvey NC, Curtis EM, Fuggle NR, Dennison EM, Cooper C (2020) The epidemiology of osteoporosis. Br Med Bull 133:105–117PubMed Clynes MA, Harvey NC, Curtis EM, Fuggle NR, Dennison EM, Cooper C (2020) The epidemiology of osteoporosis. Br Med Bull 133:105–117PubMed
4.
go back to reference Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726–1733CrossRefPubMed Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726–1733CrossRefPubMed
5.
go back to reference Tajeu GS, Delzell E, Smith W et al (2014) Death, debility, and destitution following hip fracture. J Gerontol A Biol Sci Med Sci 69:346–353CrossRefPubMed Tajeu GS, Delzell E, Smith W et al (2014) Death, debility, and destitution following hip fracture. J Gerontol A Biol Sci Med Sci 69:346–353CrossRefPubMed
7.
go back to reference Wang CB, Lin CF, Liang WM et al (2013) Excess mortality after hip fracture among the elderly in Taiwan: a nationwide population-based cohort study. Bone 56:147–153CrossRefPubMed Wang CB, Lin CF, Liang WM et al (2013) Excess mortality after hip fracture among the elderly in Taiwan: a nationwide population-based cohort study. Bone 56:147–153CrossRefPubMed
8.
go back to reference Koh GH, Tai BC, Ang LW et al (2013) All-cause and cause-specific mortality after hip fracture among Chinese women and men. Osteoporos Int 24:1981–1989CrossRefPubMed Koh GH, Tai BC, Ang LW et al (2013) All-cause and cause-specific mortality after hip fracture among Chinese women and men. Osteoporos Int 24:1981–1989CrossRefPubMed
10.
go back to reference Zeng Q, Li N, Wang Q et al (2019) The prevalence of osteoporosis in China, a nationwide, multicenter DXA survey. J Bone Miner Res 34:1789–1797CrossRefPubMed Zeng Q, Li N, Wang Q et al (2019) The prevalence of osteoporosis in China, a nationwide, multicenter DXA survey. J Bone Miner Res 34:1789–1797CrossRefPubMed
11.
go back to reference Zhang C, Feng J, Wang S et al (2020) Incidence of and trends in hip fracture among adults in urban China: a nationwide retrospective cohort study. PLoS Med 17:e1003180CrossRefPubMedPubMedCentral Zhang C, Feng J, Wang S et al (2020) Incidence of and trends in hip fracture among adults in urban China: a nationwide retrospective cohort study. PLoS Med 17:e1003180CrossRefPubMedPubMedCentral
13.
go back to reference Chen Y, Jiao Z, Chen P, Fan L, Zhou X, Pu Y et al (2021) Short-term effect of fine particulate matter and ozone on non-accidental mortality and respiratory mortality in Lishui district. China BMC Public Health 21:1661CrossRefPubMed Chen Y, Jiao Z, Chen P, Fan L, Zhou X, Pu Y et al (2021) Short-term effect of fine particulate matter and ozone on non-accidental mortality and respiratory mortality in Lishui district. China BMC Public Health 21:1661CrossRefPubMed
14.
go back to reference Toson B, Harvey LA, Close JC (2015) The ICD-10 Charlson Comorbidity Index predicted mortality but not resource utilization following hip fracture. J Clin Epidemiol 68:44–51CrossRefPubMed Toson B, Harvey LA, Close JC (2015) The ICD-10 Charlson Comorbidity Index predicted mortality but not resource utilization following hip fracture. J Clin Epidemiol 68:44–51CrossRefPubMed
15.
go back to reference Rossen LM, Ahmad FB, Anderson RN et al (2021) Disparities in excess mortality associated with COVID-19 - United States, 2020. MMWR Morb Mortal Wkly Rep 70:1114–1119CrossRefPubMedPubMedCentral Rossen LM, Ahmad FB, Anderson RN et al (2021) Disparities in excess mortality associated with COVID-19 - United States, 2020. MMWR Morb Mortal Wkly Rep 70:1114–1119CrossRefPubMedPubMedCentral
16.
go back to reference Bischoff HA, Stähelin HB, Dick W et al (2003) Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 18:343–351CrossRefPubMed Bischoff HA, Stähelin HB, Dick W et al (2003) Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 18:343–351CrossRefPubMed
17.
go back to reference Kim KM, Choi HS, Choi MJ, Chung HY (2015) Calcium and vitamin D supplementations: 2015 position statement of the Korean Society for Bone and Mineral Research. J Bone Metab 22:143–149CrossRefPubMedPubMedCentral Kim KM, Choi HS, Choi MJ, Chung HY (2015) Calcium and vitamin D supplementations: 2015 position statement of the Korean Society for Bone and Mineral Research. J Bone Metab 22:143–149CrossRefPubMedPubMedCentral
18.
go back to reference Lappe J, Cullen D, Haynatzki G, Recker R, Ahlf R, Thompson K (2008) Calcium and vitamin d supplementation decreases incidence of stress fractures in female navy recruits. J Bone Miner Res 23:741–749CrossRefPubMed Lappe J, Cullen D, Haynatzki G, Recker R, Ahlf R, Thompson K (2008) Calcium and vitamin d supplementation decreases incidence of stress fractures in female navy recruits. J Bone Miner Res 23:741–749CrossRefPubMed
19.
go back to reference Aibar-Almazán A, Voltes-Martínez A, Castellote-Caballero Y, Afanador-Restrepo DF, Carcelén-Fraile MDC, López-Ruiz E (2022) Current status of the diagnosis and management of osteoporosis. Int J Mol Sci 23:9465CrossRefPubMedPubMedCentral Aibar-Almazán A, Voltes-Martínez A, Castellote-Caballero Y, Afanador-Restrepo DF, Carcelén-Fraile MDC, López-Ruiz E (2022) Current status of the diagnosis and management of osteoporosis. Int J Mol Sci 23:9465CrossRefPubMedPubMedCentral
20.
go back to reference Ip TP, Leung J, Kung AW (2010) Management of osteoporosis in patients hospitalized for hip fractures. Osteoporos Int 21:S605–S614CrossRefPubMed Ip TP, Leung J, Kung AW (2010) Management of osteoporosis in patients hospitalized for hip fractures. Osteoporos Int 21:S605–S614CrossRefPubMed
22.
go back to reference Chakhtoura M, Dagher H, Sharara S et al (2021) Systematic review of major osteoporotic fracture to hip fracture incidence rate ratios worldwide: implications for Fracture Risk Assessment Tool (FRAX)-derived estimates. J Bone Miner Res 36:1942–1956CrossRefPubMed Chakhtoura M, Dagher H, Sharara S et al (2021) Systematic review of major osteoporotic fracture to hip fracture incidence rate ratios worldwide: implications for Fracture Risk Assessment Tool (FRAX)-derived estimates. J Bone Miner Res 36:1942–1956CrossRefPubMed
23.
go back to reference Yong EL, Ganesan G, Kramer MS, Howe TS, Koh JSB, Thu WP et al (2020) Risk factors and trends associated with mortality among adults with hip fracture in Singapore. JAMA Netw Open 3:e1919706CrossRefPubMed Yong EL, Ganesan G, Kramer MS, Howe TS, Koh JSB, Thu WP et al (2020) Risk factors and trends associated with mortality among adults with hip fracture in Singapore. JAMA Netw Open 3:e1919706CrossRefPubMed
24.
go back to reference Yoo JI, Kim HY, Jang S, Lee YK, Ha YC (2020) Risk factors for subsequent hip fractures and fatality after an initial hip fracture in Korea: using nationwide claims data. Arch Osteoporos 15:165CrossRefPubMed Yoo JI, Kim HY, Jang S, Lee YK, Ha YC (2020) Risk factors for subsequent hip fractures and fatality after an initial hip fracture in Korea: using nationwide claims data. Arch Osteoporos 15:165CrossRefPubMed
25.
go back to reference ESHRE Capri Workshop Group (2016) The influence of social factors on gender health. Hum Reprod 31:1631–1637CrossRef ESHRE Capri Workshop Group (2016) The influence of social factors on gender health. Hum Reprod 31:1631–1637CrossRef
27.
go back to reference Mustard CA, Kaufert P, Kozyrskyj A, Mayer T (1998) Sex differences in the use of health care services. N Engl J Med 338:1678–1683CrossRefPubMed Mustard CA, Kaufert P, Kozyrskyj A, Mayer T (1998) Sex differences in the use of health care services. N Engl J Med 338:1678–1683CrossRefPubMed
28.
go back to reference McLaughlin D, Vagenas D, Pachana NA, Begum N, Dobson A (2010) Gender differences in social network size and satisfaction in adults in their 70s. J Health Psychol 15:671–679CrossRefPubMed McLaughlin D, Vagenas D, Pachana NA, Begum N, Dobson A (2010) Gender differences in social network size and satisfaction in adults in their 70s. J Health Psychol 15:671–679CrossRefPubMed
29.
30.
go back to reference School of Public Health of Southeast University, Health Committee in Lishui District, Statistics Bureau in Lishui District et al (2020) Lishui Whitebook. Nanjing, China. School of Public Health of Southeast University, Health Committee in Lishui District, Statistics Bureau in Lishui District et al (2020) Lishui Whitebook. Nanjing, China.
31.
go back to reference Tosteson AN, Gottlieb DJ, Radley DC et al (2007) Excess mortality following hip fracture: the role of underlying health status. Osteoporos Int 18:1463–1472CrossRefPubMedPubMedCentral Tosteson AN, Gottlieb DJ, Radley DC et al (2007) Excess mortality following hip fracture: the role of underlying health status. Osteoporos Int 18:1463–1472CrossRefPubMedPubMedCentral
32.
go back to reference Li S, Sun T, Liu Z (2016) Excess mortality of 1 year in elderly hip fracture patients compared with the general population in Beijing. China Arch Osteoporos 11:35CrossRefPubMed Li S, Sun T, Liu Z (2016) Excess mortality of 1 year in elderly hip fracture patients compared with the general population in Beijing. China Arch Osteoporos 11:35CrossRefPubMed
33.
go back to reference Tsuboi M, Hasegawa Y, Suzuki S et al (2007) Mortality and mobility after hip fracture in Japan: a ten-year follow-up. J Bone Joint Surg Br 89:461–466CrossRefPubMed Tsuboi M, Hasegawa Y, Suzuki S et al (2007) Mortality and mobility after hip fracture in Japan: a ten-year follow-up. J Bone Joint Surg Br 89:461–466CrossRefPubMed
34.
go back to reference Wakasugi M, Kazama JJ, Wada A, Hamano T, Masakane I, Narita I (2020) Long-term excess mortality after hip fracture in hemodialysis patients: a nationwide cohort study in Japan. J Bone Miner Metab 38:718–729CrossRefPubMed Wakasugi M, Kazama JJ, Wada A, Hamano T, Masakane I, Narita I (2020) Long-term excess mortality after hip fracture in hemodialysis patients: a nationwide cohort study in Japan. J Bone Miner Metab 38:718–729CrossRefPubMed
35.
go back to reference Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP (2019) Frailty: implications for clinical practice and public health. Lancet 394:1365–1375CrossRefPubMed Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP (2019) Frailty: implications for clinical practice and public health. Lancet 394:1365–1375CrossRefPubMed
36.
go back to reference Wang O, Hu Y, Gong S et al (2015) A survey of outcomes and management of patients post fragility fractures in China. Osteoporos Int 26:2631–2640CrossRefPubMed Wang O, Hu Y, Gong S et al (2015) A survey of outcomes and management of patients post fragility fractures in China. Osteoporos Int 26:2631–2640CrossRefPubMed
37.
go back to reference Chen M, Du Y, Tang W, Yu W, Li H, Zheng S, Cheng Q (2022) Risk factors of mortality and second fracture after elderly hip fracture surgery in Shanghai, China. J Bone Miner Metab 40:951–959CrossRefPubMed Chen M, Du Y, Tang W, Yu W, Li H, Zheng S, Cheng Q (2022) Risk factors of mortality and second fracture after elderly hip fracture surgery in Shanghai, China. J Bone Miner Metab 40:951–959CrossRefPubMed
Metadata
Title
Mortality following fragility hip fracture in China: a record linkage study
Authors
Yiwen Hua
Ying Li
Jiachen Zhou
Lijun Fan
Feng Huang
Zhanpo Wu
Hui Xue
Bingquan Yang
Ping Chen
Yunfeng Rui
Yong Tian
Alireza Moayyeri
Cesar Libanati
Wei Du
Publication date
01-12-2023
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2023
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-023-01304-z

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