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Endocrine
Published in: Endocrine 2/2021

01-11-2021 | Osteoporosis | Meta- Analysis

Health-related quality of life in men with osteoporosis: a systematic review and meta-analysis

Authors: Jing Hu, Wenbing Zheng, Dichen Zhao, Lei Sun, Bingna Zhou, Jiayi Liu, Ou Wang, Yan Jiang, Weibo Xia, Xiaoping Xing, Mei Li

Published in: Endocrine | Issue 2/2021

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Abstract

Purpose

The increased social and economic burdens make osteoporosis in men an emerging public health issue. However, the quality of life among men with osteoporosis is still unclear. This systematic review and meta-analysis aimed to evaluate the health-related quality of life (HRQoL) among men with osteoporosis or osteoporotic fracture.

Methods

PubMed, EMBASE, and the Cochrane Library database were systematically searched from inception to May 2021. Studies were included if they used validated questionnaires to measure HRQoL among osteoporotic men. A meta-analysis was performed using a random-effects model or fixed-effects model to calculate the standard mean difference (SMD) or mean difference (MD) with 95% confidential interval (95% CI).

Results

14 studies involving 6338 male participants were chosen for systematic review, of which 10 were included in the meta-analysis. Men with osteoporosis had poorer global HRQoL and multiple dimensions of HRQoL than men without osteoporosis. Hip fracture, vertebral fractures, or wrist fractures dramatically impaired HRQoL of men, and physical function was declined even before hip fracture (SMD = −0.60, 95% CI, −0.82 to −0.39). Femoral and lumbar BMD was positively correlated with HRQoL, and a number of fragility fractures and time since fracture had negative effects on HRQoL. Effective anti-osteoporotic drugs could improve HRQoL of men.

Conclusion

The health-related life quality of men was significantly impaired by osteoporosis and fracture of the hip, vertebral, or wrist. We should pay more attention to the diagnosis and treatment of male osteoporosis to improve the life quality of men.
Appendix
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Metadata
Title
Health-related quality of life in men with osteoporosis: a systematic review and meta-analysis
Authors
Jing Hu
Wenbing Zheng
Dichen Zhao
Lei Sun
Bingna Zhou
Jiayi Liu
Ou Wang
Yan Jiang
Weibo Xia
Xiaoping Xing
Mei Li
Publication date
01-11-2021
Publisher
Springer US
Published in
Endocrine / Issue 2/2021
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-021-02792-0

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