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Archives of Osteoporosis
Published in: Archives of Osteoporosis 1/2020

01-12-2020 | Osteoporosis | Original Article

The urinary β2 microglobulin-creatinine ratio is inversely associated with lumbar spine bone mineral density in the elderly Chinese males

Authors: Xun Zhou, Wei Hong, Weijun Chen, Xinhui Feng, Zhenxing Zhang, Xiaoli Zhang, Chensheng Fu, Jing Xiao, Zhibin Ye

Published in: Archives of Osteoporosis | Issue 1/2020

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Abstract

Summary

Renal tubule cells play a pivotal role in maintaining bone homeostasis. Hence, renal tubular function may be associated with bone mineral density. Our study found that urinary β2 microglobulin-creatinine ratio (UBCR) levels correlated negatively with lumbar spine bone mineral density (BMD) and T and Z values, and may be a marker for osteoporosis in Chinese elderly male adults.

Purpose

To study the association of UBCR levels with BMD and the predictive value of UBCR for osteoporosis in elderly Chinese male adults.

Methods

A cross-sectional study of 149 (65 to 85 years, 69.7 ± 4.6) Chinese male adults who underwent health checkups in Huadong Hospital in Shanghai China was conducted. BMD was measured by dual-energy X-ray absorptiometry. The clinical variables and BMD of the participants in the low UBCR group (B1, UBCR < 300 μg/g) and the high UBCR group (B2, UBCR ≥ 300 μg/g) were compared. Associations between UBCR with clinical variables and BMD were analyzed by Pearson’s correlation coefficient and multiple regression analysis. BMD and T and Z values were compared between the B1 and B2 groups. The odds ratios (ORs) for dose-dependent increases in osteoporosis between B1 and B2 were analyzed by binary logistic regression analysis. The area under the receiver operating characteristic (ROC) curve was used to analyze the capacity of UBCR to predict osteoporosis.

Results

UBCR was significantly higher in the osteoporosis group. After adjusting for multiple confounders, UBCR levels correlated negatively with BMD and T and Z values of the lumbar spine. Lumbar spine BMD and T and Z values were significantly lower in the B2 UBCR group than in the B1 UBCR group. Compared with the B1 participants, the ORs for “osteoporosis” were 12.401 times higher in B2 participants (P = 0.005) by binary logistic regression analysis after adjusting for potential confounders. The UBCR index (cutoff = 362.48 μg/g) had a sensitivity of 78.6% and a specificity of 68.7% for identifying osteoporosis, with an area under the ROC curve of 0.760.

Conclusions

These results suggest that UBCR levels correlate negatively with lumbar spine BMD and T and Z values and may serve as a marker for osteoporosis in Chinese elderly male adults.
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Metadata
Title
The urinary β2 microglobulin-creatinine ratio is inversely associated with lumbar spine bone mineral density in the elderly Chinese males
Authors
Xun Zhou
Wei Hong
Weijun Chen
Xinhui Feng
Zhenxing Zhang
Xiaoli Zhang
Chensheng Fu
Jing Xiao
Zhibin Ye
Publication date
01-12-2020
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2020
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-020-00764-x

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