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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2020

01-12-2020 | Osteonecrosis of the Femoral Head | Research article

Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population

Authors: Yongchang Guo, Yuju Cao, Shunguo Gong, Sumei Zhang, Fengzhi Hou, Xinjie Zhang, Jiangeng Hu, Zhimin Yang, Juanjuan Yi, Dan Luo, Xifeng Chen, Jingbo Song

Published in: BMC Musculoskeletal Disorders | Issue 1/2020

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Abstract

Background

Osteonecrosis of the femoral head (ONFH) is a complicated disease associated with trauma, hormone abuse and excessive alcohol consumption. Polymorphisms of long non-coding RNAs have been also linked with the development of ONFH. Our research aimed to explore the relationship between CARMEN (Cardiac Mesoderm Enhancer-Associated Non-Coding RNA) variants and ONFH risk.

Methods

Our study used Agena MassARRAY Assay to genotype 6 selected single nucleotide polymorphisms (SNPs) in 731 participants (308 alcohol-induced ONFH patients and 423 controls). We used odds ratios (ORs) and 95% confidence intervals (CIs) to calculate the effect of gene polymorphisms on the occurrence of alcohol-induced ONFH by logistic regression analysis and haplotype analysis.

Results

Our overall analysis illustrated that rs13177623 and rs12654195 had an association with a reduced risk of ONFH after adjustment for age and gender. We also found that rs13177623, rs12654195 and rs11168100 were associated with a decreased susceptibility to alcohol-induced ONFH in people ≤45 years. In addition, the necrotic sites stratification analysis showed that rs12654195 was only found to be related to alcohol-induced ONFH risk in the recessive model. In patients with different clinical stages, rs353300 was observed to be associated with a higher incidence of ONFH. Individuals with different genotypes of rs13177623, rs12654195 and rs11168100 had significantly different clinical parameters (cholinesterase, globulin, percentage of neutrophils and the absolute value of lymphocytes).

Conclusions

Our data provided new light on the association between CARMEN polymorphisms and alcohol-induced ONFH risk in the Chinese Han population.
Appendix
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Metadata
Title
Correlation analysis between CARMEN variants and alcohol-induced osteonecrosis of the femoral head in the Chinese population
Authors
Yongchang Guo
Yuju Cao
Shunguo Gong
Sumei Zhang
Fengzhi Hou
Xinjie Zhang
Jiangeng Hu
Zhimin Yang
Juanjuan Yi
Dan Luo
Xifeng Chen
Jingbo Song
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2020
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-020-03553-2

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