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Journal of Bone and Mineral Metabolism
Published in: Journal of Bone and Mineral Metabolism 2/2014

01-03-2014 | Case Report

Osteomalacia induced by vitamin D deficiency in hemodialysis patients: the crucial role of vitamin D correction

Authors: Fabrice Mac-Way, Linda Azzouz, Christian Noel, Marie-Hélène Lafage-Proust

Published in: Journal of Bone and Mineral Metabolism | Issue 2/2014

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Abstract

Vitamin D deficiency/insufficiency is significantly prevalent in chronic kidney disease. Data in the literature are however scarce about the effects of this deficiency on bone metabolism in hemodialysis (HD) patients. Moreover, it is still debated whether low vitamin D levels should be normalized in HD patients. In this paper, we report two cases showing the deleterious consequences of vitamin D deficiency in HD patients which is characterised by hypophosphatemia, hypocalcemia and osteomalacia (OM) leading to bone fractures. As vitamin D repletion is an easy way to treat OM, this report underlines the importance of monitoring and correction of vitamin D deficiency in this population.
Literature
1.
Wald R, Sarnak MJ, Tighiouart H, Cheung AK, Levey AS, Eknoyan G, Miskulin DC (2008) Disordered mineral metabolism in hemodialysis patients: an analysis of cumulative effects in the Hemodialysis (HEMO) Study. Am J Kidney Dis 52:531–540PubMedCrossRef
2.
Block GA, Hulbert-Shearon TE, Levin NW, Port FK (1998) Association of serum phosphorus and calcium × phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am J Kidney Dis 31:607–617PubMedCrossRef
3.
Noordzij M, Korevaar JC, Boeschoten EW, Dekker FW, Bos WJ, Krediet RT (2005) The kidney disease outcomes quality initiative (K/DOQI) guideline for bone metabolism and disease in CKD: association with mortality in dialysis patients. Am J Kidney Dis 46:925–932PubMedCrossRef
4.
Jean G, Terrat JC, Vanel T, Hurot JM, Lorriaux C, Mayor B, Chazot C (2008) Daily oral 25-hydroxycholecalciferol supplementation for vitamin D deficiency in haemodialysis patients: effects on mineral metabolism and bone markers. Nephrol Dial Transplant 23:3670–3676PubMedCrossRef
5.
Wolf M, Shah A, Gutierrez O, Ankers E, Monroy M, Tamez H, Steele D, Chang Y, Camargo CA Jr, Tonelli M, Thadhani R (2007) Vitamin D levels and early mortality among incident hemodialysis patients. Kidney Int 72:1004–1013PubMedCrossRef
6.
Mailliez S, Shahapuni I, Lecaque C, Massy ZA, Choukroun G, Fournier A (2008) Vitamin D levels and early mortality among incident hemodialysis patients. Kidney Int 74:389PubMedCrossRef
7.
Pilz S, Iodice S, Zittermann A, Grant WB, Gandini S (2011) Vitamin D status and mortality risk in CKD: a meta-analysis of prospective studies. Am J Kidney Dis 58:374–382PubMed
8.
Moe SM, Drüeke TB, Block GA, Cannata-Andía JB, Elder GJ et al (2009) KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl 113:S1–S130
9.
Nickolas TL, McMahon DJ, Shane E (2006) Relationship between moderate to severe kidney disease and hip fracture in the United States. J Am Soc Nephrol 17:3223–3232PubMedCrossRef
10.
Nickolas TL, Leonard MB, Shane E (2008) Chronic kidney disease and bone fracture: a growing concern. Kidney Int 74:721–731PubMedCrossRef
11.
Albalate M, Gruss E, Hernandez J, Caramelo C (2003) Hypophosphatemia in dialysis units. Nefrologia 23:252–256PubMed
12.
Blair D, Byham-Gray L, Lewis E, McCaffrey S (2008) Prevalence of vitamin D [25(OH)D] deficiency and effects of supplementation with ergocalciferol (vitamin D2) in stage 5 chronic kidney disease patients. J Ren Nutr 18:375–382PubMedCrossRef
13.
Del Valle E, Negri AL, Aguirre C, Fradinger E, Zanchetta JR (2007) Prevalence of 25(OH) vitamin D insufficiency and deficiency in chronic kidney disease stage 5 patients on hemodialysis. Hemodial Int 11:315–321PubMedCrossRef
14.
15.
Gonzalez EA, Sachdeva A, Oliver DA, Martin KJ (2004) Vitamin D insufficiency and deficiency in chronic kidney disease: a single center observational study. Am J Nephrol 24:503–510PubMedCrossRef
16.
Patel S, Barron JL, Mirzazedeh M, Gallagher H, Hyer S, Cantor T, Fraser WD (2011) Changes in bone mineral parameters, vitamin D metabolites, and PTH measurements with varying chronic kidney disease stages. J Bone Miner Metab 29:71–79PubMedCrossRef
17.
Targher G, Bertolini L, Padovani R, Zenari L, Scala L, Cigolini M, Arcaro G (2006) Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients. Clin Endocrinol (Oxf) 65:593–597CrossRef
18.
Giovannucci E, Liu Y, Hollis BW, Rimm EB (2008) 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med 168:1174–1180PubMedCentralPubMedCrossRef
19.
Mizoue T, Kimura Y, Toyomura K, Nagano J, Kono S, Mibu R, Tanaka M, Kakeji Y, Maehara Y, Okamura T, Ikejiri K, Futami K, Yasunami Y, Maekawa T, Takenaka K, Ichimiya H, Imaizumi N (2008) Calcium, dairy foods, vitamin D, and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. Cancer Epidemiol Biomarkers Prev 17:2800–2807PubMedCrossRef
20.
Abbas S, Chang-Claude J, Linseisen J (2009) Plasma 25-hydroxyvitamin D and premenopausal breast cancer risk in a German case-control study. Int J Cancer 124:250–255PubMedCrossRef
21.
Eastwood JB, Stamp TC, Harris E, de Wardener HE (1976) Vitamin-D deficiency in the osteomalacia of chronic renal failure. Lancet 2:1209–1211PubMedCrossRef
22.
Ghazali A, Fardellone P, Pruna A, Atik A, Achard JM, Oprisiu R, Brazier M, Remond A, Moriniere P, Garabedian M, Eastwood J, Fournier A (1999) Is low plasma 25-(OH)vitamin D a major risk factor for hyperparathyroidism and Looser’s zones independent of calcitriol? Kidney Int 55:2169–2177PubMedCrossRef
23.
Ambrus C, Almasi C, Berta K, Deak G, Marton A, Molnar MZ, Nemeth Z, Horvath C, Lakatos P, Szathmari M, Mucsi I (2011) Vitamin D insufficiency and bone fractures in patients on maintenance hemodialysis. Int Urol Nephrol 43:475–482PubMedCrossRef
24.
Atkins GJ, Anderson PH, Findlay DM, Welldon KJ, Vincent C, Zannettino AC, O’Loughlin PD, Morris HA (2007) Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 α,25-dihydroxyvitamin D3. Bone 40:1517–1528PubMedCrossRef
25.
Turner AG, Anderson PH, Morris HA (2012) Vitamin D and bone health. Scand J Clin Lab Invest Suppl 243:65–72PubMed
26.
Jean G, Terrat JC, Vanel T, Hurot JM, Lorriaux C, Mayor B, Chazot C (2008) Evidence for persistent vitamin D 1-α-hydroxylation in hemodialysis patients: evolution of serum 1,25-dihydroxycholecalciferol after 6 months of 25-hydroxycholecalciferol treatment. Nephron Clin Pract 110:c58–c65PubMedCrossRef
27.
Hernandez JD, Wesseling K, Boechat MI, Gales B, Salusky IB (2007) Osteomalacia in a hemodialysis patient receiving an active vitamin D sterol. Nat Clin Pract Nephrol 3:227–232PubMedCrossRef
Metadata
Title
Osteomalacia induced by vitamin D deficiency in hemodialysis patients: the crucial role of vitamin D correction
Authors
Fabrice Mac-Way
Linda Azzouz
Christian Noel
Marie-Hélène Lafage-Proust
Publication date
01-03-2014
Publisher
Springer Japan
Published in
Journal of Bone and Mineral Metabolism / Issue 2/2014
Print ISSN: 0914-8779
Electronic ISSN: 1435-5604
DOI
https://doi.org/10.1007/s00774-013-0480-7

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