Top

Published in:

01-07-2019 | Osteoarthrosis | Review Article

Rheumatic associations of autoimmune thyroid disease: a systematic review

Authors: Clement E. Tagoe, Tejas Sheth, Eugeniya Golub, Karen Sorensen

Published in: Clinical Rheumatology | Issue 7/2019

Abstract

To investigate specific disease patterns in the rheumatic manifestations associated with autoimmune thyroid disease (AITD) through a systematic literature review. We performed a systematic review using the Medline OVID, PubMed, EMBASE, and Web of Science databases through May 2018 for experimental and observational studies that explored the association of AITD with degenerative joint disease (DJD), osteoarthritis (OA), chronic widespread pain (CWP) and fibromyalgia syndrome (FMS), and seronegative inflammatory arthritis (IA). A total of 2132 articles were identified. After title and abstract screening and removal of duplicates, 66 articles were retrieved for full text review. Eighteen studies were deemed eligible for inclusion. Six observational studies reported up to 45% prevalence of DJD in AITD. Hand and spinal DJD were reportedly associated with higher odds of AITD. Twelve observational studies were retrieved reporting up to 62% prevalence of FMS in AITD patients. Four studies described the occurrence of seronegative IA in AITD patients. The rheumatic associations of AITD may manifest specific patterns of disease distinct from those of other well-defined autoimmune syndromes and contribute significantly to disease burden.

Available only for authorised users

Dayan CM, Daniels GH (1996) Chronic autoimmune thyroiditis. N Engl J Med 335(2):99–107. https://doi.org/10.1056/nejm199607113350206 CrossRefPubMed

Caturegli P, De Remigis A, Rose NR (2014) Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev 13(4–5):391–397. https://doi.org/10.1016/j.autrev.2014.01.007 CrossRefPubMed

Weetman AP (2009) The genetics of autoimmune thyroid disease. Horm Metab Res 41(6):421–425. https://doi.org/10.1055/s-0029-1214415 CrossRefPubMed

Cho JH, Gregersen PK (2011) Genomics and the multifactorial nature of human autoimmune disease. N Engl J Med 365(17):1612–1623. https://doi.org/10.1056/NEJMra1100030 CrossRefPubMed

Tomer Y (2014) Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics. Annu Rev Pathol 9:147–156. https://doi.org/10.1146/annurev-pathol-012513-104713 CrossRefPubMedPubMedCentral

Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE (2015) Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 518(7539):337–343. https://doi.org/10.1038/nature13835 CrossRef

Guyatt GH, Oxman AD, Kunz R, Vist GE, Falck-Ytter Y, Schunemann HJ (2008) What is “quality of evidence” and why is it important to clinicians? BMJ 336(7651):995–998. https://doi.org/10.1136/bmj.39490.551019.BE CrossRefPubMedPubMedCentral

Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, Braverman LE (2002) Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87(2):489–499CrossRef

Somers EC, Thomas SL, Smeeth L, Hall AJ (2006) Autoimmune diseases co-occurring within individuals and within families: a systematic review. Epidemiology 17(2):202–217. https://doi.org/10.1097/01.ede.0000193605.93416.df CrossRefPubMed

10.

Rapoport B, McLachlan SM (2001) Thyroid autoimmunity. J Clin Invest 108(9):1253–1259. https://doi.org/10.1172/JCI14321 CrossRefPubMedPubMedCentral

11.

Boelaert K, Newby PR, Simmonds MJ, Holder RL, Carr-Smith JD, Heward JM, Manji N, Allahabadia A, Armitage M, Chatterjee KV, Lazarus JH, Pearce SH, Vaidya B, Gough SC, Franklyn JA (2010) Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. Am J Med 123(2):183.e181–183.e189. https://doi.org/10.1016/j.amjmed.2009.06.030 CrossRef

12.

Biro E, Szekanecz Z, Czirjak L, Danko K, Kiss E, Szabo NA, Szucs G, Zeher M, Bodolay E, Szegedi G, Bako G (2006) Association of systemic and thyroid autoimmune diseases. Clin Rheumatol 25(2):240–245. https://doi.org/10.1007/s10067-005-1165-y CrossRefPubMed

13.

Tagoe CE, Zezon A, Khattri S (2012) Rheumatic manifestations of autoimmune thyroid disease: the other autoimmune disease. J Rheumatol 39(6):1125–1129. https://doi.org/10.3899/jrheum.120022 CrossRefPubMed

14.

Haynes RB, Wilczynski NL (2004) Optimal search strategies for retrieving scientifically strong studies of diagnosis from Medline: analytical survey. BMJ 328(7447):1040. https://doi.org/10.1136/bmj.38068.557998.EE CrossRefPubMedPubMedCentral

15.

Haynes RB, Wilczynski N, McKibbon KA, Walker CJ, Sinclair JC (1994) Developing optimal search strategies for detecting clinically sound studies in MEDLINE. J Am Med Inform Assoc 1(6):447–458CrossRef

16.

Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P, Fam AG, Farber SJ, Fiechtner JJ, Michael Franklin C, Gatter RA, Hamaty D, Lessard J, Lichtbroun AS, Masi AT, Mccain GA, John Reynolds W, Romano TJ, Jon Russell I, Sheon RP (1990) The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 33(2):160–172CrossRef

17.

Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, Russell AS, Russell IJ, Winfield JB, Yunus MB (2010) The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken) 62(5):600–610. https://doi.org/10.1002/acr.20140 CrossRef

18.

Altman R, Alarcon G, Appelrouth D, Bloch D, Borenstein D, Brandt K, Brown C, Cooke TD, Daniel W, Feldman D et al (1991) The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis Rheum 34(5):505–514CrossRef

19.

Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M et al (1986) Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 29(8):1039–1049CrossRef

20.

Altman R, Alarcon G, Appelrouth D, Bloch D, Borenstein D, Brandt K, Brown C, Cooke TD, Daniel W, Gray R, Greenwald R, Hochberg M, Howell D, Ike R, Kapila P, Kaplan D, Koopman W, Longley S, Mcshane DJ, Medsger T, Michel B, Murphy W, Osial T, Ramsey-Goldman R, Rothschild B, Stark K, Wolfe F (1990) The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum 33(11):1601–1610CrossRef

21.

Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339:b2535CrossRef

22.

Kim SY, Park JE, Lee YJ, Seo HJ, Sheen SS, Hahn S, Jang BH, Son HJ (2013) Testing a tool for assessing the risk of bias for nonrandomized studies showed moderate reliability and promising validity. J Clin Epidemiol 66(4):408–414. https://doi.org/10.1016/j.jclinepi.2012.09.016 CrossRefPubMed

23.

Soy M, Guldiken S, Arikan E, Altun BU, Tugrul A (2007) Frequency of rheumatic diseases in patients with autoimmune thyroid disease. Rheumatol Int 27(6):575–577. https://doi.org/10.1007/s00296-006-0263-8 CrossRefPubMed

24.

Mobini M, Kashi Z, Ravanbakhsh N (2011) Thyroid disorders in rheumatoid arthritis and osteoarthritis. Pak J Med Sci 27(3):595–598

25.

Addimanda O, Mancarella L, Dolzani P, Ramonda R, Fioravanti A, Brusi V, Pignotti E, Meliconi R (2012) Clinical associations in patients with hand osteoarthritis. Scand J Rheumatol 41(4):310–313. https://doi.org/10.3109/03009742.2012.656699 CrossRefPubMed

26.

Hezarkhani S, Sedighi S, Aghaei M, Shamekhi M, Nomali M (2014) Rheumatologic manifestations in Iranian patients with autoimmune thyroid diseases. J Clin Diagn Res 8(10):MC06–MC08. https://doi.org/10.7860/JCDR/2014/7974.4981 CrossRefPubMedPubMedCentral

27.

Tagoe CE, Zezon A, Khattri S, Castellanos P (2013) Rheumatic manifestations of euthyroid, anti-thyroid antibody-positive patients. Rheumatol Int 33(7):1745–1752. https://doi.org/10.1007/s00296-012-2616-9 CrossRefPubMed

28.

Shrestha A, Cohen HW, Tagoe CE (2016) Association of spinal degenerative disc disease with thyroid autoimmunity. Clin Exp Rheumatol 33(7):1745–1752. https://doi.org/10.1007/s00296-012-2616-9 CrossRef

29.

Bazzichi L, Rossi A, Giuliano T, De Feo F, Giacomelli C, Consensi A, Ciapparelli A, Consoli G, Dell'osso L, Bombardieri S (2007) Association between thyroid autoimmunity and fibromyalgic disease severity. Clin Rheumatol 26(12):2115–2120. https://doi.org/10.1007/s10067-007-0636-8 CrossRefPubMed

30.

Bazzichi L, Rossi A, Zirafa C, Monzani F, Tognini S, Dardano A, Santini F, Tonacchera M, De Servi M, Giacomelli C, De Feo F, Doveri M, Massimetti G, Bombardieri S (2012) Thyroid autoimmunity may represent a predisposition for the development of fibromyalgia? Rheumatol Int 32(2):335–341. https://doi.org/10.1007/s00296-010-1620-1 CrossRefPubMed

31.

Aarflot T, Bruusgaard D (1996) Association between chronic widespread musculoskeletal complaints and thyroid autoimmunity. Results from a community survey. Scand J Prim Health Care 14(2):111–115CrossRef

32.

Ribeiro LS, Proietti FA (2004) Interrelations between fibromyalgia, thyroid autoantibodies, and depression. J Rheumatol 31(10):2036–2040

33.

Pamuk ON, Cakir N (2007) The frequency of thyroid antibodies in fibromyalgia patients and their relationship with symptoms. Clin Rheumatol 26(1):55–59. https://doi.org/10.1007/s10067-006-0237-y CrossRef

34.

Suk JH, Lee JH, Kim JM (2012) Association between thyroid autoimmunity and fibromyalgia. Exp Clin Endocrinol Diabetes 120(7):401–404. https://doi.org/10.1055/s-0032-1309008 CrossRefPubMed

35.

Ahmad J, Blumen H, Tagoe CE (2015) Association of antithyroid peroxidase antibody with fibromyalgia in rheumatoid arthritis. Rheumatol Int 35(8):1415–1421. https://doi.org/10.1007/s00296-015-3278-1 CrossRefPubMed

36.

Başkan BM, Sivas F, Aktekin LA, Yurdakul FG, Çinar NK, Bodur H, Özoran K (2010) Relationship between thyroid autoimmunity and depression, quality of life, and disease symptoms in patients with fibromyalgia and rheumatoid arthritis. Turk J Rheumatol 25(3):130–136CrossRef

37.

Haliloglu SEB, Uzkeser H, Sevimli H, Carlioglu A, Macit PM (2017) Fibromyalgia in patients with thyroid autoimmunity: prevalence and relationship with disease activity. Clin Rheumatol 36(7):1617–1621. https://doi.org/10.1007/s10067-017-3556-2 CrossRefPubMed

38.

Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Hauser W, Katz RS, Mease P, Russell AS, Russell IJ, Winfield JB (2011) Fibromyalgia criteria and severity scales for clinical and epidemiological studies: a modification of the ACR Preliminary Diagnostic Criteria for Fibromyalgia. J Rheumatol 38(6):1113–1122. https://doi.org/10.3899/jrheum.100594 CrossRefPubMed

39.

Mosca M, Carli L, d'Ascanio A, Tani C, Talarico R, Baldini C, Bazzichi L, Tavoni A, Migliorini P, Bombardieri S (2008) Occurrence of organ-specific and systemic autoimmune diseases among the first- and second-degree relatives of Caucasian patients with connective tissue diseases: report of data obtained through direct patient interviews. Clin Rheumatol 27(8):1045–1048. https://doi.org/10.1007/s10067-008-0904-2 CrossRefPubMed

40.

LeRiche NG, Bell DA (1984) Hashimoto's thyroiditis and polyarthritis: a possible subset of seronegative polyarthritis. Ann Rheum Dis 43(4):594–598CrossRef

41.

Golding DN (1993) Rheumatism and the thyroid. J R Soc Med 86(3):130–132PubMedPubMedCentral

42.

Punzi L, Michelotto M, Pianon M, Bertazzolo N, Fagiolo U, Betterle C, Vettor R, Todesco S (1997) Clinical, laboratory and immunogenetic aspects of arthritis associated with chronic lymphocytic thyroiditis. Clin Exp Rheumatol 15(4):373–380PubMed

43.

Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, Guyatt GH, Harbour RT, Haugh MC, Henry D, Hill S, Jaeschke R, Leng G, Liberati A, Magrini N, Mason J, Middleton P, Mrukowicz J, O'Connell D, Oxman AD, Phillips B, Schunemann HJ, Edejer T, Varonen H, Vist GE, Williams JW Jr, Zaza S (2004) Grading quality of evidence and strength of recommendations. BMJ 328(7454):1490. https://doi.org/10.1136/bmj.328.7454.1490 CrossRef

44.

Elattar EA, Younes TB, Mobasher SA (2014) Hypothyroidism in patients with rheumatoid arthritis and its relation to disease activity. Egypt Rheumatol Rehabil 41(2):58–65CrossRef

45.

Joshi P, Agarwal A, Vyas S, Kumar R (2016) Prevalence of hypothyroidism in rheumatoid arthritis and its correlation with disease activity. Trop Dr 47:6–10. https://doi.org/10.1177/0049475515627235 CrossRef

46.

Raterman HG, Voskuyl AE, Simsek S, Schreurs MW, van Hoogstraten IM, Peters MJ, van Halm VP, Dijkmans BA, Lips P, Lems WF, Nurmohamed MT (2013) Increased progression of carotid intima media thickness in thyroid peroxidase antibodies-positive rheumatoid arthritis patients. Eur J Endocrinol / European Federation of Endocrine Societies 169(6):751–757. https://doi.org/10.1530/eje-13-0394 CrossRef

47.

Koszarny A, Majdan M, Suszek D, Wielosz E, Dryglewska M (2013) Relationship between rheumatoid arthritis activity and antithyroid antibodies. Pol Arch Med Wewn 123(7–8):394–400PubMed

48.

Cakir M, Samanci N, Balci N, Balci MK (2003) Musculoskeletal manifestations in patients with thyroid disease. Clin Endocrinol 59(2):162–167. https://doi.org/10.1046/j.1365-2265.2003.01786.x CrossRef

49.

Doyle L (1991) Myxoedema: some early reports and contributions by British authors, 1873-1898. J R Soc Med 84(2):103–106CrossRef

50.

Gillan MM, Scofield RH, Harley JB (2002) Hashimoto’s thyroiditis presenting as bilateral knee arthropathy. J Okla State Med Assoc 95(5):323–325PubMed

51.

Branco JC, Bannwarth B, Failde I, Abello Carbonell J, Blotman F, Spaeth M, Saraiva F, Nacci F, Thomas E, Caubere JP, Le Lay K, Taieb C, Matucci-Cerinic M (2010) Prevalence of fibromyalgia: a survey in five European countries. Semin Arthritis Rheum 39(6):448–453. https://doi.org/10.1016/j.semarthrit.2008.12.003 CrossRefPubMed

52.

Vanhoof J, Declerck K, Geusens P (2002) Prevalence of rheumatic diseases in a rheumatological outpatient practice. Ann Rheum Dis 61(5):453–455CrossRef

53.

Becker KL, Ferguson RH, Mc CW (1963) The connective-tissue diseases and symptoms associated with Hashimoto’s thyroiditis. N Engl J Med 268:277–280. https://doi.org/10.1056/nejm196302072680601 CrossRefPubMed

54.

Ahmad J, Tagoe CE (2014) Fibromyalgia and chronic widespread pain in autoimmune thyroid disease. Clin Rheumatol 33(7):885–891. https://doi.org/10.1007/s10067-014-2490-9 CrossRefPubMed

55.

Pyne D, Isenberg DA (2002) Autoimmune thyroid disease in systemic lupus erythematosus. Ann Rheum Dis 61(1):70–72CrossRef

56.

Pan XF, Gu JQ, Shan ZY (2015) Increased risk of thyroid autoimmunity in rheumatoid arthritis: a systematic review and meta-analysis. Endocrine 50(1):79–86. https://doi.org/10.1007/s12020-015-0533-x CrossRefPubMed

57.

Pan XF, Gu JQ, Shan ZY (2015) Patients with systemic lupus erythematosus have higher prevalence of thyroid autoantibodies: a systematic review and meta-analysis. PLoS One 10(4):e0123291. https://doi.org/10.1371/journal.pone.0123291 CrossRefPubMedPubMedCentral

58.

Franco JS, Amaya-Amaya J, Molano-Gonzalez N, Caro-Moreno J, Rodriguez-Jimenez M, Acosta-Ampudia Y, Mantilla RD, Rojas-Villarraga A, Anaya JM (2015) Autoimmune thyroid disease in Colombian patients with systemic lupus erythematosus. Clin Endocrinol 83(6):943–950. https://doi.org/10.1111/cen.12662 CrossRef

59.

Appenzeller S, Pallone AT, Natalin RA, Costallat LT (2009) Prevalence of thyroid dysfunction in systemic lupus erythematosus. J Clin Rheumatol 15(3):117–119. https://doi.org/10.1097/RHU.0b013e31819dbe4c CrossRefPubMed

60.

Dessein PH, Joffe BI, Stanwix AE (2004) Subclinical hypothyroidism is associated with insulin resistance in rheumatoid arthritis. Thyroid 14(6):443–446. https://doi.org/10.1089/105072504323150750 CrossRefPubMed

61.

Zhuo Q, Yang W, Chen J, Wang Y (2012) Metabolic syndrome meets osteoarthritis. Nat Rev Rheumatol 8(12):729–737. https://doi.org/10.1038/nrrheum.2012.135 CrossRefPubMed

62.

Raterman HG, van Halm VP, Voskuyl AE, Simsek S, Dijkmans BA, Nurmohamed MT (2008) Rheumatoid arthritis is associated with a high prevalence of hypothyroidism that amplifies its cardiovascular risk. Ann Rheum Dis 67(2):229–232. https://doi.org/10.1136/ard.2006.068130 CrossRefPubMed

63.

Smith LL, Burnet SP, McNeil JD (2003) Musculoskeletal manifestations of diabetes mellitus. Br J Sports Med 37(1):30–35CrossRef

64.

Erkoç S, Karaahmet ÖZ, Bal A, Çakci A (2011) Evaluation of thyroid function in patients presenting with musculoskeletal complaints. J Rheumatol Med Rehabil 22(1):1–7

Title: Rheumatic associations of autoimmune thyroid disease: a systematic review
Authors: Clement E. Tagoe
Tejas Sheth
Eugeniya Golub
Karen Sorensen
Publication date: 01-07-2019
Publisher: Springer London
Keywords: Osteoarthrosis
Thyroid Disease
Hashimoto Thyroiditis
Fibromyalgia
Thyroid Disease
Arthritis
Osteoarthrosis
Fibromyalgia
Rheumatoid Arthritis
Published in: Clinical Rheumatology / Issue 7/2019
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-019-04498-1

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits

Illustration of figure on mountain summit/© Orapun / Stock.adobe.com, STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 7/2019

When brucellosis met the Assessment of SpondyloArthritis international Society classification criteria for spondyloarthritis: a comparative study

The efficacy and safety of antithrombotic therapy in patients with positive antiphospholipid antibodies receiving invasive procedures: experience from a single tertiary center

Juvenile polymyositis associated with ureteral necrosis: a diagnostic and therapeutic dilemma—case report and review of the literature

Neurosonological and cognitive screening for evaluation of systemic sclerosis patients

Comparison of the 2017 EULAR/ACR criteria with Bohan and Peter criteria for the classification of idiopathic inflammatory myopathies

Effect of flaxseed poultice compress application on pain and hand functions of patients with hand osteoarthritis

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

Highlights from the ACC 2024 Congress

ACC 2024 Congress Coverage