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Knee Surgery, Sports Traumatology, Arthroscopy

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01-07-2023 | Osteoarthrosis | Editorial

Disease-modifying effects of orthobiologics in the treatment of knee osteoarthritis: the lesson learned from preclinical research models

Authors: Laura de Girolamo, Giuseppe Filardo, Lior Laver

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 12/2023

Graphical Abstract

Allaeys C, Arnout N, Van Onsem S, Govaers K, Victor J (2020) Conservative treatment of knee osteoarthritis. Acta Orthop Belg 86(3):412–421PubMed

Belk JW, Kraeutler MJ, Houck DA, Goodrich JA, Dragoo JL, McCarty EC (2021) Platelet-rich plasma versus hyaluronic acid for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Am J Sports Med 49(1):249–260CrossRefPubMed

Boffa A, PeruccaOrfei C, Sourugeon Y, Laver L, Magalon J, Sánchez, et al (2023) Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA orthobiologic initiative. Part 2: bone marrow-derived cell-based injectable therapies. Knee Surg Sports Traumatol Arthrosc. 31(2):641–655CrossRefPubMed

Boffa A, Salerno M, Merli G, de Girolamo L, Laver L, Magalon J et al (2021) Platelet-rich plasma injections induce disease-modifying effects in the treatment of osteoarthritis in animal models. Knee Surg Sports Traumatol Arthrosc 29(12):4100–4121CrossRefPubMed

Bolia IK, Bougioukli S, Hill WJ, Trasolini NA, Petrigliano FA, Lieberman JR et al (2022) Clinical efficacy of bone marrow aspirate concentrate versus stromal vascular fraction injection in patients with knee osteoarthritis: a systematic review and meta-analysis. Am J Sports Med 50(5):1451–1461CrossRefPubMed

Chu J, Duan W, Yu Z, Tao T, Xu J, Ma Q et al (2022) Intra-articular injections of platelet-rich plasma decrease pain and improve functional outcomes than sham saline in patients with knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc 30(12):4063–4071CrossRefPubMed

Filardo G, Previtali D, Napoli F, Candrian C, Zaffagnini S, Grassi A (2021) PRP injections for the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials. Cartilage 13(1_suppl):364S–375S

Funck-Brentano T, Nethander M, Movérare-Skrtic S, Richette P, Ohlsson C (2019) Causal factors for knee, hip, and hand osteoarthritis: a mendelian randomization study in the UK Biobank. Arthritis Rheumatol 71(10):1634–1641CrossRefPubMedPubMedCentral

Goldring MB (2012) Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis. Ther Adv Musculoskelet Dis 4(4):269–285CrossRefPubMedPubMedCentral

10.

Hohmann E, Tetsworth K, Glatt V (2020) Is platelet-rich plasma effective for the treatment of knee osteoarthritis? A systematic review and meta-analysis of level 1 and 2 randomized controlled trials. Eur J Orthop Surg Traumatol 30(6):955–967CrossRefPubMed

11.

Hunter D, Bierma-Zeinstra S (2019) Osteoarthritis. Lancet Lond Engl 393:1745–1759CrossRef

12.

Kim KI, Kim MS, Kim JH (2022) Intra-articular injection of autologous adipose-derived stem cells or stromal vascular fractions: are they effective for patients with knee osteoarthritis? A systematic review with meta-analysis of randomized controlled trials. Am J Sports Med 12:3635465211053893

13.

Klein JC, Keith A, Rice SJ et al (2019) Functional testing of thousands of osteoarthritis-associated variants for regulatory activity. Nat Commun 10(1):2434. https://doi.org/10.1038/s41467-019-10439-yCrossRefPubMedPubMedCentral

14.

Kon E, Boffa A, Andriolo L, Di Martino A, Di Matteo B, Magarelli N et al (2022) Combined subchondral and intra-articular injections of bone marrow aspirate concentrate provide stable results up to 24 months. Knee Surg Sports Traumatol Arthrosc. https://doi.org/10.1007/s00167-022-07195-wCrossRefPubMedPubMedCentral

15.

Laver L, Marom N, Dnyanesh L, Mei-Dan O, Espregueira-Mendes J, Gobbi A (2017) PRP for degenerative cartilage disease: a systematic review of clinical studies. Cartilage 8(4):341–364CrossRefPubMed

16.

Long H, Liu Q, Yin H, Wang K, Diao N, Zhang Y et al (2022) Prevalence trends of site-specific osteoarthritis from 1990 to 2019: findings from the global burden of disease study 2019. Arthritis Rheumatol 74(7):1172–1183CrossRefPubMedPubMedCentral

17.

McLarnon M, Heron N (2021) Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: systematic review and meta-analysis. BMC Musculoskelet Disord 22(1):550. https://doi.org/10.1186/s12891-021-04308-3CrossRefPubMedPubMedCentral

18.

PeruccaOrfei C, Boffa A, Sourugeon Y, Laver L, Magalon J, Sánchez M et al (2023) Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA Orthobiologic Initiative. Part 1: adipose tissue-derived cell-based injectable therapies. Knee Surg Sports Traumatol Arthrosc. 31(2):641–655CrossRef

19.

Ulivi M, Meroni V, Viganò M, Colombini A, Lombardo MDM, Rossi N et al (2022) Micro-fragmented adipose tissue (mFAT) associated with arthroscopic debridement provides functional improvement in knee osteoarthritis: a randomized controlled trial. Knee Surg Sports Traumatol Arthrosc 30:1–12

20.

Yurtbay A, Say F, Çinka H, Ersoy A (2022) Multiple platelet-rich plasma injections are superior to single PRP injections or saline in osteoarthritis of the knee: the 2-year results of a randomized, double-blind, placebo-controlled clinical trial. Arch Orthop Trauma Surg 142(10):2755–2768CrossRefPubMed

Title: Disease-modifying effects of orthobiologics in the treatment of knee osteoarthritis: the lesson learned from preclinical research models
Authors: Laura de Girolamo
Giuseppe Filardo
Lior Laver
Publication date: 01-07-2023
Publisher: Springer Berlin Heidelberg
Keywords: Osteoarthrosis
Osteoarthrosis
Knee Osteoarthritis
Knee Osteoarthritis
Published in: Knee Surgery, Sports Traumatology, Arthroscopy / Issue 12/2023
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI: https://doi.org/10.1007/s00167-023-07423-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Disease-modifying effects of orthobiologics in the treatment of knee osteoarthritis: the lesson learned from preclinical research models

Graphical Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Graphical Abstract

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