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Current Reviews in Musculoskeletal Medicine

Published in:

01-12-2020 | Osteoarthrosis | Hot Topics

Current Applications of Growth Factors for Knee Cartilage Repair and Osteoarthritis Treatment

Authors: Sarav S. Shah, Kai Mithoefer

Published in: Current Reviews in Musculoskeletal Medicine | Issue 6/2020

Abstract

Purpose of Review

The decreased contact area, edge loading, and increased stress in the adjacent area cartilage resulting from chondral defects are believed to predispose this tissue to degenerative changes that have significant economic implications, especially when considering its progression to osteoarthritis of the knee. Growth factors are considered therapeutic possibilities to enhance healing of chondral injuries and modify the progression to degenerative arthritis. Thus, the purposes of this review are to first to summarize important points for defect preparation and recent advances in techniques for marrow stimulation and second, and to identify specific growth factors and cytokines that have the capacity to advance cartilage regeneration and the treatment of osteoarthritis in light of recent laboratory and clinical studies.

Recent Findings

TGF-β, BMP-2, BMP-7, IGF-1, as IL-1 receptor antagonist, and recombinant human FGF-18 are some of the promising growth factor/cytokine treatments with pioneering and evolving clinical developments. The bulk of the review describes and discusses these developments in light of fundamental basic science. It is crucial to also understand the other underlying advances made in the surgical management of cartilage defects prior to onset of OA. These advances are in techniques for defect preparation and marrow stimulation, a common cartilage repair procedure used in combination with growth factor/cytokine augmentation.

Summary

Multiple growth factor/cytokine modulation therapies are currently undergoing clinical trial investigation including Invossa (currently in phase III study), Kineret (currently in phase I study), and Sprifermin (currently in phase II study) for the treatment of symptomatic osteoarthritis.

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Title: Current Applications of Growth Factors for Knee Cartilage Repair and Osteoarthritis Treatment
Authors: Sarav S. Shah
Kai Mithoefer
Publication date: 01-12-2020
Publisher: Springer US
Keywords: Osteoarthrosis
Osteoarthrosis
Cytokines
Growth Factors
Growth Factors
Published in: Current Reviews in Musculoskeletal Medicine / Issue 6/2020
Electronic ISSN: 1935-9748
DOI: https://doi.org/10.1007/s12178-020-09664-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Current Applications of Growth Factors for Knee Cartilage Repair and Osteoarthritis Treatment

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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