Skip to main content
Top
Published in: BMC Geriatrics 1/2022

Open Access 01-12-2022 | Osteoarthrosis | Research

Factors influencing depression in community-dwelling elderly patients with osteoarthritis of the knee in China: a cross-sectional study

Authors: Xiaoyan Zheng, Yaya Wang, Xiaoyan Jin, Hongjie Huang, Hongbo Chen, Yan Wang, Shaomei Shang

Published in: BMC Geriatrics | Issue 1/2022

Login to get access

Abstract

Background

Knee osteoarthritis (OA) and depression are both major health issues influencing the quality of elderly life. The aim of the present study was to explore the prevalence of depression and the factors influencing depression in community-dwelling elderly patients with OA of the knee in China.

Methods

We conducted a cross-sectional descriptive study. The study included 214 participants aged 60 and older diagnosed with OA of the knee. The depression of the elderly was measured by using the Geriatric Depression Scale (GDS). Participants were asked to complete a demographic questionnaire, the GDS, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the society dimension of Arthritis Impact Measurement Scales 2 (AIMS2). In addition, the participants performed a timed up and go test (TUG) and the stair-climb test (SCT).

Results

The average age of the participants was 69.2 ± 7.63 years old, their body mass index (BMI) was 25.2 ± 3.85, and their disease duration was 5.9 ± 7.72 years. The mean total score of the GDS was 4.43 ± 2.89, and the GDS scores correlated positively with pain (r = 0.45, P < 0.001), stiffness (r = 0.40, P < 0.001), physical function (r = 0.52, P < 0.001),TUG (r = 0.35, P < 0.001), and SCT (r = 0.47, P < 0.001) and negatively with social support (r = − 0.35, P < 0.001).Analysis using multiple regression demonstrated that physical function, social support, and SCT explained 36.8% of the variance in depression.

Conclusions

Our findings suggested that physical function, social support, and lower extremity strength were predictors of depressive symptoms in community-dwelling elderly people with OA of the knee. Focusing on this elderly group with increasing functional exercise, positive social interaction and support, and lower limb muscle strength training should help in the prevention of depression.
Appendix
Available only for authorised users
Literature
1.
go back to reference Stubbs B, Aluko Y, Myint PK, Smith TO. Prevalence of depressive symptoms and anxiety in osteoarthritis: a systematic review and meta-analysis. Age Ageing. 2016;45(2):228–35.PubMedCrossRef Stubbs B, Aluko Y, Myint PK, Smith TO. Prevalence of depressive symptoms and anxiety in osteoarthritis: a systematic review and meta-analysis. Age Ageing. 2016;45(2):228–35.PubMedCrossRef
2.
go back to reference Sun X, Zhen X, Hu X, Li Y, Gu S, Gu Y, et al. Osteoarthritis in the Middle-Aged and Elderly in China: Prevalence and Influencing Factors[J]. Int J Environ Res Public Health. 2019;16(23): 4701. Sun X, Zhen X, Hu X, Li Y, Gu S, Gu Y, et al. Osteoarthritis in the Middle-Aged and Elderly in China: Prevalence and Influencing Factors[J]. Int J Environ Res Public Health. 2019;16(23): 4701.
3.
go back to reference Tang X, Wang S, Zhan S, Niu J, Tao K, Zhang Y, et al. The prevalence of symptomatic knee osteoarthritis in China: results from the China health and retirement longitudinal study. Arthritis Rheumatol. 2016;68(3):648–53.PubMedCrossRef Tang X, Wang S, Zhan S, Niu J, Tao K, Zhang Y, et al. The prevalence of symptomatic knee osteoarthritis in China: results from the China health and retirement longitudinal study. Arthritis Rheumatol. 2016;68(3):648–53.PubMedCrossRef
4.
go back to reference Ahn H, Weaver M, Lyon D, Choi E, Fillingim RB. Depression and pain in Asian and White Americans with knee osteoarthritis. J Pain. 2017;18(10):1229–36.PubMedPubMedCentralCrossRef Ahn H, Weaver M, Lyon D, Choi E, Fillingim RB. Depression and pain in Asian and White Americans with knee osteoarthritis. J Pain. 2017;18(10):1229–36.PubMedPubMedCentralCrossRef
5.
go back to reference Shang X, Peng W, Hill E, Szoeke C, He M, Zhang L. Incidence of medication-treated depression and anxiety associated with long-term Cancer, cardiovascular disease, diabetes and osteoarthritis in community-dwelling women and men. EClinicalMedicine. 2019;15:23–32.PubMedPubMedCentralCrossRef Shang X, Peng W, Hill E, Szoeke C, He M, Zhang L. Incidence of medication-treated depression and anxiety associated with long-term Cancer, cardiovascular disease, diabetes and osteoarthritis in community-dwelling women and men. EClinicalMedicine. 2019;15:23–32.PubMedPubMedCentralCrossRef
6.
go back to reference Saracino RM, Weinberger MI, Roth AJ, Hurria A, Nelson CJ. Assessing depression in a geriatric cancer population. Psychooncology. 2017;26(10):1484–90.PubMedCrossRef Saracino RM, Weinberger MI, Roth AJ, Hurria A, Nelson CJ. Assessing depression in a geriatric cancer population. Psychooncology. 2017;26(10):1484–90.PubMedCrossRef
7.
go back to reference Arnow BA, Blasey CM, Lee J, Fireman B, Hunkeler EM, Dea R, et al. Relationships among depression, chronic pain, chronic disabling pain, and medical costs. Psychiatr Serv. 2009;60(3):344–50.PubMedCrossRef Arnow BA, Blasey CM, Lee J, Fireman B, Hunkeler EM, Dea R, et al. Relationships among depression, chronic pain, chronic disabling pain, and medical costs. Psychiatr Serv. 2009;60(3):344–50.PubMedCrossRef
8.
go back to reference Kojima M, Kojima T, Suzuki S, Takahashi N, Funahashi K, Kato D, et al. Alexithymia, depression, inflammation, and pain in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2014;66(5):679–86.CrossRef Kojima M, Kojima T, Suzuki S, Takahashi N, Funahashi K, Kato D, et al. Alexithymia, depression, inflammation, and pain in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2014;66(5):679–86.CrossRef
9.
go back to reference Margaretten M, Yelin E, Imboden J, Graf J, Barton J, Katz P, et al. Predictors of depression in a multiethnic cohort of patients with rheumatoid arthritis. Arthritis Rheum. 2009;61(11):1586–91.PubMedPubMedCentralCrossRef Margaretten M, Yelin E, Imboden J, Graf J, Barton J, Katz P, et al. Predictors of depression in a multiethnic cohort of patients with rheumatoid arthritis. Arthritis Rheum. 2009;61(11):1586–91.PubMedPubMedCentralCrossRef
10.
11.
go back to reference Aravena JM, Saguez R, Lera L, Moya MO, Albala C. Factors related to depressive symptoms and self-reported diagnosis of depression in community-dwelling older Chileans: A national cross-sectional analysis. Int J Geriatr Psychiatry. 2020;35(7):749–58. Aravena JM, Saguez R, Lera L, Moya MO, Albala C. Factors related to depressive symptoms and self-reported diagnosis of depression in community-dwelling older Chileans: A national cross-sectional analysis. Int J Geriatr Psychiatry. 2020;35(7):749–58.
12.
go back to reference Aree-Ue S, Kongsombun U, Roopsawang I, Youngcharoen P. Path model of factors influencing health-related quality of life among older people with knee osteoarthritis. Nurs Health Sci. 2019;21(3):345–51.PubMedCrossRef Aree-Ue S, Kongsombun U, Roopsawang I, Youngcharoen P. Path model of factors influencing health-related quality of life among older people with knee osteoarthritis. Nurs Health Sci. 2019;21(3):345–51.PubMedCrossRef
13.
go back to reference Lee Y, Shinkai S. Correlates of cognitive impairment and depressive symptoms among older adults in Korea and Japan. Int J Geriatr Psychiatry. 2005;20(6):576–86.PubMedCrossRef Lee Y, Shinkai S. Correlates of cognitive impairment and depressive symptoms among older adults in Korea and Japan. Int J Geriatr Psychiatry. 2005;20(6):576–86.PubMedCrossRef
14.
go back to reference Iijima H, Aoyama T, Fukutani N, Isho T, Yamamoto Y, Hiraoka M, et al. Psychological health is associated with knee pain and physical function in patients with knee osteoarthritis: an exploratory cross-sectional study. BMC Psychol. 2018;6(1):19.PubMedPubMedCentralCrossRef Iijima H, Aoyama T, Fukutani N, Isho T, Yamamoto Y, Hiraoka M, et al. Psychological health is associated with knee pain and physical function in patients with knee osteoarthritis: an exploratory cross-sectional study. BMC Psychol. 2018;6(1):19.PubMedPubMedCentralCrossRef
15.
go back to reference Charles-Lozoya S, Cobos-Aguilar H, Tamez-Montes JC, Brizuela-Ventura JM, Rangel-Valenzuela JM, Garcia-Hernandez A. Obesity, depression and factors associated to the quality of life in total knee arthroplasty. Cir Cir. 2020;88(2):143–9.PubMed Charles-Lozoya S, Cobos-Aguilar H, Tamez-Montes JC, Brizuela-Ventura JM, Rangel-Valenzuela JM, Garcia-Hernandez A. Obesity, depression and factors associated to the quality of life in total knee arthroplasty. Cir Cir. 2020;88(2):143–9.PubMed
16.
go back to reference Batsis JA, Zbehlik AJ, Pidgeon D, Bartels SJ. Dynapenic obesity and the effect on long-term physical function and quality of life: data from the osteoarthritis initiative. BMC Geriatr. 2015;15:118.PubMedPubMedCentralCrossRef Batsis JA, Zbehlik AJ, Pidgeon D, Bartels SJ. Dynapenic obesity and the effect on long-term physical function and quality of life: data from the osteoarthritis initiative. BMC Geriatr. 2015;15:118.PubMedPubMedCentralCrossRef
17.
go back to reference Chen H, Zheng X, Huang H, Liu C, Wan Q, Shang S. The effects of a home-based exercise intervention on elderly patients with knee osteoarthritis: a quasi-experimental study. BMC Musculoskelet Disord. 2019;20(1):160.PubMedPubMedCentralCrossRef Chen H, Zheng X, Huang H, Liu C, Wan Q, Shang S. The effects of a home-based exercise intervention on elderly patients with knee osteoarthritis: a quasi-experimental study. BMC Musculoskelet Disord. 2019;20(1):160.PubMedPubMedCentralCrossRef
19.
go back to reference Lee HCB, Chiu HFK, Kwok WY, Leung CM, Kwong PK, Chung DWS. Chinese elderly and the GDS short form: a preliminary study. Clin Gerontol. 1993;14:37–42. Lee HCB, Chiu HFK, Kwok WY, Leung CM, Kwong PK, Chung DWS. Chinese elderly and the GDS short form: a preliminary study. Clin Gerontol. 1993;14:37–42.
20.
go back to reference Sheikh JI, Yesavage JA. Geriatric depression scale (GDS): recent evidence and development of a shorter version. Clin Gerontol. 1986;5:165–73.CrossRef Sheikh JI, Yesavage JA. Geriatric depression scale (GDS): recent evidence and development of a shorter version. Clin Gerontol. 1986;5:165–73.CrossRef
21.
go back to reference Minami U, Nishi M, Fukaya T, Hasebe M, Nonaka K, Koike T, et al. Effects of the change in working status on the health of older people in Japan. PLoS One. 2015;10(12):e0144069.PubMedPubMedCentralCrossRef Minami U, Nishi M, Fukaya T, Hasebe M, Nonaka K, Koike T, et al. Effects of the change in working status on the health of older people in Japan. PLoS One. 2015;10(12):e0144069.PubMedPubMedCentralCrossRef
22.
go back to reference Shah A, Herbert R, Lewis S, Mahendran R, Platt J, Bhattacharyya B. Screening for depression among acutely ill geriatric inpatients with a short geriatric depression scale. Age Ageing. 1997;26(3):217–21.PubMedCrossRef Shah A, Herbert R, Lewis S, Mahendran R, Platt J, Bhattacharyya B. Screening for depression among acutely ill geriatric inpatients with a short geriatric depression scale. Age Ageing. 1997;26(3):217–21.PubMedCrossRef
23.
go back to reference Bae JN, Cho MJ. Development of the Korean version of the geriatric depression scale and its short form among elderly psychiatric patients. J Psychosom Res. 2004;57(3):297–305.PubMedCrossRef Bae JN, Cho MJ. Development of the Korean version of the geriatric depression scale and its short form among elderly psychiatric patients. J Psychosom Res. 2004;57(3):297–305.PubMedCrossRef
24.
go back to reference Kwak Y, Song S, Yang Y. The relationship between geriatric depression scale structure and cognitive-behavioral aspects in patients with Alzheimer’s disease. Dement Neurocognitive Disord. 2015;14:24–30.CrossRef Kwak Y, Song S, Yang Y. The relationship between geriatric depression scale structure and cognitive-behavioral aspects in patients with Alzheimer’s disease. Dement Neurocognitive Disord. 2015;14:24–30.CrossRef
25.
go back to reference Bellamy N, Buchanan WW. A preliminary evaluation of the dimensionality and clinical importance of pain and disability in osteoarthritis of the hip and knee. Clin Rheumatol. 1986;5(2):231–41.PubMedCrossRef Bellamy N, Buchanan WW. A preliminary evaluation of the dimensionality and clinical importance of pain and disability in osteoarthritis of the hip and knee. Clin Rheumatol. 1986;5(2):231–41.PubMedCrossRef
26.
go back to reference Symonds T, Hughes B, Liao S, Ang Q, Bellamy N. Validation of the Chinese Western Ontario and McMaster universities osteoarthritis index in patients from mainland China with osteoarthritis of the knee. Arthritis Care Res (Hoboken). 2015;67(11):1553–60.CrossRef Symonds T, Hughes B, Liao S, Ang Q, Bellamy N. Validation of the Chinese Western Ontario and McMaster universities osteoarthritis index in patients from mainland China with osteoarthritis of the knee. Arthritis Care Res (Hoboken). 2015;67(11):1553–60.CrossRef
27.
go back to reference Guillemin F, Coste J, Pouchot J, Ghezail M, Bregeon C, Sany J. The AIMS2-SF: a short form of the arthritis impact measurement scales 2. French quality of life in rheumatology group. Arthritis Rheum. 1997;40(7):1267–74.PubMed Guillemin F, Coste J, Pouchot J, Ghezail M, Bregeon C, Sany J. The AIMS2-SF: a short form of the arthritis impact measurement scales 2. French quality of life in rheumatology group. Arthritis Rheum. 1997;40(7):1267–74.PubMed
28.
go back to reference Chu EM, Chiu KY, Wong RW, Tang WM, Lau CS. Translation and validation of arthritis impact measurement scales 2 into Chinese: CAIMS2. Arthritis Rheum. 2004;51(1):20–7.PubMedCrossRef Chu EM, Chiu KY, Wong RW, Tang WM, Lau CS. Translation and validation of arthritis impact measurement scales 2 into Chinese: CAIMS2. Arthritis Rheum. 2004;51(1):20–7.PubMedCrossRef
29.
go back to reference Lai Z, Lee S, Hu X, Wang L. Effect of adding whole-body vibration training to squat training on physical function and muscle strength in individuals with knee osteoarthritis. J Musculoskelet Neuronal Interact. 2019;19(3):333–41.PubMedPubMedCentral Lai Z, Lee S, Hu X, Wang L. Effect of adding whole-body vibration training to squat training on physical function and muscle strength in individuals with knee osteoarthritis. J Musculoskelet Neuronal Interact. 2019;19(3):333–41.PubMedPubMedCentral
30.
go back to reference Podsiadlo D, Richardson S. The timed "up & go": a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39(2):142–8.PubMedCrossRef Podsiadlo D, Richardson S. The timed "up & go": a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39(2):142–8.PubMedCrossRef
31.
go back to reference Lin MR, Hwang HF, Hu MH, Wu HD, Wang YW, Huang FC. Psychometric comparisons of the timed up and go, one-leg stand, functional reach, and Tinetti balance measures in community-dwelling older people. J Am Geriatr Soc. 2004;52(8):1343–8.PubMedCrossRef Lin MR, Hwang HF, Hu MH, Wu HD, Wang YW, Huang FC. Psychometric comparisons of the timed up and go, one-leg stand, functional reach, and Tinetti balance measures in community-dwelling older people. J Am Geriatr Soc. 2004;52(8):1343–8.PubMedCrossRef
32.
go back to reference Focht BC, Rejeski WJ, Ambrosius WT, Katula JA, Messier SP. Exercise, self-efficacy, and mobility performance in overweight and obese older adults with knee osteoarthritis. Arthritis Rheum. 2005;53(5):659–65.PubMedCrossRef Focht BC, Rejeski WJ, Ambrosius WT, Katula JA, Messier SP. Exercise, self-efficacy, and mobility performance in overweight and obese older adults with knee osteoarthritis. Arthritis Rheum. 2005;53(5):659–65.PubMedCrossRef
33.
go back to reference Iijima H, Shimoura K, Eguchi R, Aoyama T, Takahashi M. Concurrent validity and measurement error of stair climb test in people with pre-radiographic to mild knee osteoarthritis. Gait Posture. 2019;68:335–9.PubMedCrossRef Iijima H, Shimoura K, Eguchi R, Aoyama T, Takahashi M. Concurrent validity and measurement error of stair climb test in people with pre-radiographic to mild knee osteoarthritis. Gait Posture. 2019;68:335–9.PubMedCrossRef
34.
go back to reference Peng L, Yan Y, Hou X, Niu D, Wei J, Wang J. Evaluation of the effect of a three-color ladder management model for knee osteoarthritis in the community. Am J Transl Res. 2021;13(4):3074–83.PubMedPubMedCentral Peng L, Yan Y, Hou X, Niu D, Wei J, Wang J. Evaluation of the effect of a three-color ladder management model for knee osteoarthritis in the community. Am J Transl Res. 2021;13(4):3074–83.PubMedPubMedCentral
35.
go back to reference Qian M, Chen R, Chen H, Hu S, Zhong J, Yao P, et al. Counselling and psychotherapy services in more developed and developing regions in China: a comparative investigation of practitioners and current service delivery. Int J Soc Psychiatry. 2012;58(5):536–43.PubMedCrossRef Qian M, Chen R, Chen H, Hu S, Zhong J, Yao P, et al. Counselling and psychotherapy services in more developed and developing regions in China: a comparative investigation of practitioners and current service delivery. Int J Soc Psychiatry. 2012;58(5):536–43.PubMedCrossRef
36.
go back to reference Wu F, Narimatsu H, Li X, Nakamura S, Sho R, Zhao G, et al. Non-communicable diseases control in China and Japan. Glob Health. 2017;13(1):91.CrossRef Wu F, Narimatsu H, Li X, Nakamura S, Sho R, Zhao G, et al. Non-communicable diseases control in China and Japan. Glob Health. 2017;13(1):91.CrossRef
37.
go back to reference Charlton RA, Lamar M, Zhang A, Ren X, Ajilore O, Pandey GN, et al. Associations between pro-inflammatory cytokines, learning, and memory in late-life depression and healthy aging. Int J Geriatr Psychiatry. 2018;33(1):104–12.PubMedCrossRef Charlton RA, Lamar M, Zhang A, Ren X, Ajilore O, Pandey GN, et al. Associations between pro-inflammatory cytokines, learning, and memory in late-life depression and healthy aging. Int J Geriatr Psychiatry. 2018;33(1):104–12.PubMedCrossRef
38.
go back to reference Lin EH, Katon W, Von Korff M, Tang L, Williams JW Jr, Kroenke K, et al. Effect of improving depression care on pain and functional outcomes among older adults with arthritis: a randomized controlled trial. Jama. 2003;290(18):2428–9.PubMedCrossRef Lin EH, Katon W, Von Korff M, Tang L, Williams JW Jr, Kroenke K, et al. Effect of improving depression care on pain and functional outcomes among older adults with arthritis: a randomized controlled trial. Jama. 2003;290(18):2428–9.PubMedCrossRef
39.
go back to reference Harris T, Cook DG, Victor C, DeWilde S, Beighton C. Onset and persistence of depression in older people--results from a 2-year community follow-up study. Age Ageing. 2006;35(1):25–32.PubMedCrossRef Harris T, Cook DG, Victor C, DeWilde S, Beighton C. Onset and persistence of depression in older people--results from a 2-year community follow-up study. Age Ageing. 2006;35(1):25–32.PubMedCrossRef
41.
go back to reference Zheng S, Tu L, Cicuttini F, Zhu Z, Han W, Antony B, et al. Depression in patients with knee osteoarthritis: risk factors and associations with joint symptoms. BMC Musculoskelet Disord. 2021;22(1):40.PubMedPubMedCentralCrossRef Zheng S, Tu L, Cicuttini F, Zhu Z, Han W, Antony B, et al. Depression in patients with knee osteoarthritis: risk factors and associations with joint symptoms. BMC Musculoskelet Disord. 2021;22(1):40.PubMedPubMedCentralCrossRef
42.
go back to reference Helminen EE, Sinikallio SH, Valjakka AL, Väisänen-Rouvali RH, Arokoski JP. Effectiveness of a cognitive-behavioural group intervention for knee osteoarthritis pain: a randomized controlled trial. Clin Rehabil. 2015;29(9):868–81. Helminen EE, Sinikallio SH, Valjakka AL, Väisänen-Rouvali RH, Arokoski JP. Effectiveness of a cognitive-behavioural group intervention for knee osteoarthritis pain: a randomized controlled trial. Clin Rehabil. 2015;29(9):868–81.
43.
go back to reference Makizako H, Shimada H, Doi T, Yoshida D, Anan Y, Tsutsumimoto K, et al. Physical frailty predicts incident depressive symptoms in elderly people: prospective findings from the Obu study of health promotion for the elderly. J Am Med Dir Assoc. 2015;16(3):194–9.PubMedCrossRef Makizako H, Shimada H, Doi T, Yoshida D, Anan Y, Tsutsumimoto K, et al. Physical frailty predicts incident depressive symptoms in elderly people: prospective findings from the Obu study of health promotion for the elderly. J Am Med Dir Assoc. 2015;16(3):194–9.PubMedCrossRef
44.
go back to reference Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377(9783):2115–26.PubMedCrossRef Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377(9783):2115–26.PubMedCrossRef
45.
go back to reference Chen PY, Song CY, Yen HY, Lin PC, Chen SR, Lu LH, et al. Impacts of tai chi exercise on functional fitness in community-dwelling older adults with mild degenerative knee osteoarthritis: a randomized controlled clinical trial. BMC Geriatr. 2021;21(1):449.PubMedPubMedCentralCrossRef Chen PY, Song CY, Yen HY, Lin PC, Chen SR, Lu LH, et al. Impacts of tai chi exercise on functional fitness in community-dwelling older adults with mild degenerative knee osteoarthritis: a randomized controlled clinical trial. BMC Geriatr. 2021;21(1):449.PubMedPubMedCentralCrossRef
46.
go back to reference Chen L, Alston M, Guo W. The influence of social support on loneliness and depression among older elderly people in China: coping styles as mediators. J Community Psychol. 2019;47(5):1235–45.PubMedCrossRef Chen L, Alston M, Guo W. The influence of social support on loneliness and depression among older elderly people in China: coping styles as mediators. J Community Psychol. 2019;47(5):1235–45.PubMedCrossRef
47.
go back to reference Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H, et al. Osteoarthritis. Lancet. 2015;386(9991):376–87.PubMedCrossRef Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H, et al. Osteoarthritis. Lancet. 2015;386(9991):376–87.PubMedCrossRef
48.
go back to reference Stevenson JD, Roach R. The benefits and barriers to physical activity and lifestyle interventions for osteoarthritis affecting the adult knee. J Orthop Surg Res. 2012;7:15.PubMedPubMedCentralCrossRef Stevenson JD, Roach R. The benefits and barriers to physical activity and lifestyle interventions for osteoarthritis affecting the adult knee. J Orthop Surg Res. 2012;7:15.PubMedPubMedCentralCrossRef
50.
go back to reference Dunlop DD, Song J, Semanik PA, Sharma L, Chang RW. Physical activity levels and functional performance in the osteoarthritis initiative: a graded relationship. Arthritis Rheum. 2011;63(1):127–36.PubMedPubMedCentralCrossRef Dunlop DD, Song J, Semanik PA, Sharma L, Chang RW. Physical activity levels and functional performance in the osteoarthritis initiative: a graded relationship. Arthritis Rheum. 2011;63(1):127–36.PubMedPubMedCentralCrossRef
51.
go back to reference Fitzgerald GK, White DK, Piva SR. Associations for change in physical and psychological factors and treatment response following exercise in knee osteoarthritis: an exploratory study. Arthritis Care Res (Hoboken). 2012;64(11):1673–80.CrossRef Fitzgerald GK, White DK, Piva SR. Associations for change in physical and psychological factors and treatment response following exercise in knee osteoarthritis: an exploratory study. Arthritis Care Res (Hoboken). 2012;64(11):1673–80.CrossRef
Metadata
Title
Factors influencing depression in community-dwelling elderly patients with osteoarthritis of the knee in China: a cross-sectional study
Authors
Xiaoyan Zheng
Yaya Wang
Xiaoyan Jin
Hongjie Huang
Hongbo Chen
Yan Wang
Shaomei Shang
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2022
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-022-03117-0

Other articles of this Issue 1/2022

BMC Geriatrics 1/2022 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine