Skip to main content
Top
Published in: Clinical Reviews in Bone and Mineral Metabolism 2/2016

01-06-2016 | Locomotive Syndrome

Osteoarthritis as a Cause of Locomotive Syndrome: Its Influence on Functional Mobility and Activities of Daily Living

Authors: Muneaki Ishijima, Haruka Kaneko, Shinnosuke Hada, Mayuko Kinoshita, Ryo Sadatsuki, Lizu Liu, Yukio Shimura, Hitoshi Arita, Jun Shiozawa, Anwarjan Yusup, Ippei Futami, Yuko Sakamoto, Masayoshi Ishibashi, Syuichi Machida, Hisashi Naito, Eri Arikawa-Hirasawa, Chieko Hamada, Yoshitomo Saita, Yuji Takazawa, Hiroshi Ikeda, Yasunori Okada, Kazuo Kaneko

Published in: Clinical & Translational Metabolism | Issue 2/2016

Login to get access

Abstract

“Locomotive syndrome” is defined as a condition associated with restriction in one’s ability to walk or lead a normal life due to a dysfunction in one or more of the parts of the locomotion system, including the muscles, bones, joints, cartilage or intervertebral discs. This syndrome especially refers to individuals who have come to need nursing care services because of problems with the locomotive organs, or those who have conditions which may require them to need such services in the near future. Recent epidemiological studies revealed that the one-fourth of elderly individuals who require special assistance or nursing care have locomotive disorders in Japan. Osteoarthritis of the knee (knee OA) and hip (hip OA), and osteoporosis and spinal canal stenosis due to spondylosis are three major locomotive disorders that cause elderly individuals require special assistance or nursing care. In this review, we focus on the effects of knee and hip OA on the lives of elderly individuals and the recent advantages in clinical research on the pathophysiology and management of these diseases.
Literature
1.
go back to reference Global Burden of Disease Study 2013 Collaborators. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition. Lancet. 2013;386(10009):2145–91. doi:10.1016/S0140-6736(15)61340-X. Global Burden of Disease Study 2013 Collaborators. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition. Lancet. 2013;386(10009):2145–91. doi:10.​1016/​S0140-6736(15)61340-X.
3.
go back to reference Yoshimura N, Muraki S, Oka H, Mabuchi A, En-Yo Y, Yoshida M, et al. Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study. J Bone Miner Metab. 2009;27(5):620–8. doi:10.1007/s00774-009-0080-8.CrossRefPubMed Yoshimura N, Muraki S, Oka H, Mabuchi A, En-Yo Y, Yoshida M, et al. Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study. J Bone Miner Metab. 2009;27(5):620–8. doi:10.​1007/​s00774-009-0080-8.CrossRefPubMed
4.
6.
go back to reference Muraki S, Oka H, Akune T, Mabuchi A, En-yo Y, Yoshida M, et al. Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: the ROAD study. Osteoarthritis Cartilage. 2009;17(9):1137–43. doi:10.1016/j.joca.2009.04.005.CrossRefPubMed Muraki S, Oka H, Akune T, Mabuchi A, En-yo Y, Yoshida M, et al. Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: the ROAD study. Osteoarthritis Cartilage. 2009;17(9):1137–43. doi:10.​1016/​j.​joca.​2009.​04.​005.CrossRefPubMed
7.
go back to reference Guccione AA, Felson DT, Anderson JJ, Anthony JM, Zhang Y, Wilson PW, et al. The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health. 1994;84(3):351–8.CrossRefPubMedPubMedCentral Guccione AA, Felson DT, Anderson JJ, Anthony JM, Zhang Y, Wilson PW, et al. The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health. 1994;84(3):351–8.CrossRefPubMedPubMedCentral
8.
go back to reference Dieppe PA, Lohmander LS. Pathogenesis and management of pain in osteoarthritis. Lancet. 2005;365(9463):965–73.CrossRefPubMed Dieppe PA, Lohmander LS. Pathogenesis and management of pain in osteoarthritis. Lancet. 2005;365(9463):965–73.CrossRefPubMed
13.
go back to reference Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage. 2008;16(2):137–62. doi:10.1016/j.joca.2007.12.013.CrossRefPubMed Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage. 2008;16(2):137–62. doi:10.​1016/​j.​joca.​2007.​12.​013.CrossRefPubMed
16.
go back to reference Manno RL, Bingham CO 3rd, Paternotte S, Gossec L, Halhol H, Giacovelli G, et al. OARSI-OMERACT initiative: defining thresholds for symptomatic severity and structural changes in disease modifying osteoarthritis drug (DMOAD) clinical trials. Osteoarthritis Cartilage. 2012;20(2):93–101. doi:10.1016/j.joca.2011.11.013.CrossRefPubMed Manno RL, Bingham CO 3rd, Paternotte S, Gossec L, Halhol H, Giacovelli G, et al. OARSI-OMERACT initiative: defining thresholds for symptomatic severity and structural changes in disease modifying osteoarthritis drug (DMOAD) clinical trials. Osteoarthritis Cartilage. 2012;20(2):93–101. doi:10.​1016/​j.​joca.​2011.​11.​013.CrossRefPubMed
17.
go back to reference Wise BL, Felson DT, Clancy M, Niu J, Neogi T, Lane NE, et al. Consistency of knee pain and risk of knee replacement: the Multicenter Osteoarthritis Study. J Rheumatol. 2011;38(7):1390–5.CrossRefPubMedPubMedCentral Wise BL, Felson DT, Clancy M, Niu J, Neogi T, Lane NE, et al. Consistency of knee pain and risk of knee replacement: the Multicenter Osteoarthritis Study. J Rheumatol. 2011;38(7):1390–5.CrossRefPubMedPubMedCentral
18.
go back to reference Naylor CD, Williams JI. Primary hip and knee replacement surgery: Ontario criteria for case selection and surgical priority. Qual Health Care. 1996;5(1):20–30.CrossRefPubMedPubMedCentral Naylor CD, Williams JI. Primary hip and knee replacement surgery: Ontario criteria for case selection and surgical priority. Qual Health Care. 1996;5(1):20–30.CrossRefPubMedPubMedCentral
19.
go back to reference Maillefert JF, Hawker GA, Gossec L, Mahomed NN, Lohmander S, Dieppe PA, et al. Concomitant therapy: an outcome variable for musculoskeletal disorders? Part 2: total joint replacement in osteoarthritis trials. J Rheumatol. 2005;32(12):2449–51.PubMed Maillefert JF, Hawker GA, Gossec L, Mahomed NN, Lohmander S, Dieppe PA, et al. Concomitant therapy: an outcome variable for musculoskeletal disorders? Part 2: total joint replacement in osteoarthritis trials. J Rheumatol. 2005;32(12):2449–51.PubMed
20.
go back to reference Gossec L, Tubach F, Baron G, Ravaud P, Logeart I, Dougados M. Predictive factors of total hip replacement due to primary osteoarthritis: a prospective 2 year study of 505 patients. Ann Rheum Dis. 2005;64(7):1028–32.CrossRefPubMedPubMedCentral Gossec L, Tubach F, Baron G, Ravaud P, Logeart I, Dougados M. Predictive factors of total hip replacement due to primary osteoarthritis: a prospective 2 year study of 505 patients. Ann Rheum Dis. 2005;64(7):1028–32.CrossRefPubMedPubMedCentral
21.
go back to reference Hawker GA, Guan J, Croxford R, Coyte PC, Glazier RH, Harvey BJ, et al. A prospective population-based study of the predictors of undergoing total joint arthroplasty. Arthritis Rheum. 2006;54(10):3212–20.CrossRefPubMed Hawker GA, Guan J, Croxford R, Coyte PC, Glazier RH, Harvey BJ, et al. A prospective population-based study of the predictors of undergoing total joint arthroplasty. Arthritis Rheum. 2006;54(10):3212–20.CrossRefPubMed
22.
go back to reference Gossec L, Hawker G, Davis AM, Maillefert JF, Lohmander LS, Altman R, et al. OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis. J Rheumatol. 2007;34(6):1432–5.PubMed Gossec L, Hawker G, Davis AM, Maillefert JF, Lohmander LS, Altman R, et al. OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis. J Rheumatol. 2007;34(6):1432–5.PubMed
23.
go back to reference Gossec L, Paternotte S, Bingham CO 3rd, Clegg DO, Coste P, Conaghan PG, et al. OARSI/OMERACT initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis. An OMERACT 10 Special Interest Group. J Rheumatol. 2011;38(8):1765–9.CrossRefPubMedPubMedCentral Gossec L, Paternotte S, Bingham CO 3rd, Clegg DO, Coste P, Conaghan PG, et al. OARSI/OMERACT initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis. An OMERACT 10 Special Interest Group. J Rheumatol. 2011;38(8):1765–9.CrossRefPubMedPubMedCentral
24.
go back to reference Gossec L, Paternotte S, Maillefert JF, Combescure C, Conaghan PG, Davis AM, et al. The role of pain and functional impairment in the decision to recommend total joint replacement in hip and knee osteoarthritis: an international cross-sectional study of 1909 patients. Report of the OARSI-OMERACT Task Force on total joint replacement. Osteoarthritis Cartilage. 2011;19(2):147–54.CrossRefPubMed Gossec L, Paternotte S, Maillefert JF, Combescure C, Conaghan PG, Davis AM, et al. The role of pain and functional impairment in the decision to recommend total joint replacement in hip and knee osteoarthritis: an international cross-sectional study of 1909 patients. Report of the OARSI-OMERACT Task Force on total joint replacement. Osteoarthritis Cartilage. 2011;19(2):147–54.CrossRefPubMed
25.
go back to reference Dieppe P. Who should have a joint replacement? A plea for more ‘phronesis’. Osteoarthritis Cartilage. 2011;19(2):145–6.CrossRefPubMed Dieppe P. Who should have a joint replacement? A plea for more ‘phronesis’. Osteoarthritis Cartilage. 2011;19(2):145–6.CrossRefPubMed
26.
go back to reference Dieppe P, Lim K, Lohmander S. Who should have knee joint replacement surgery for osteoarthritis? Int J Rheum Dis. 2011;14(2):175–80.CrossRefPubMed Dieppe P, Lim K, Lohmander S. Who should have knee joint replacement surgery for osteoarthritis? Int J Rheum Dis. 2011;14(2):175–80.CrossRefPubMed
27.
go back to reference Liu L, Ishijima M, Kaneko H, Futami I, Sadatsuki R, Hada S, et al. Disability for daily living is a predictor for joint replacement in patients with end-stage knee osteoarthritis. J Bone Miner Metab. 2014;32(2):192–9. doi:10.1007/s00774-013-0487-0.CrossRefPubMed Liu L, Ishijima M, Kaneko H, Futami I, Sadatsuki R, Hada S, et al. Disability for daily living is a predictor for joint replacement in patients with end-stage knee osteoarthritis. J Bone Miner Metab. 2014;32(2):192–9. doi:10.​1007/​s00774-013-0487-0.CrossRefPubMed
28.
go back to reference Liddle AD, Judge A, Pandit H, Murray DW. Adverse outcomes after total and unicompartmental knee replacement in 101,330 matched patients: a study of data from the National Joint Registry for England and Wales. Lancet. 2014;384(9952):1437–45. doi:10.1016/S0140-6736(14)60419-0.CrossRefPubMed Liddle AD, Judge A, Pandit H, Murray DW. Adverse outcomes after total and unicompartmental knee replacement in 101,330 matched patients: a study of data from the National Joint Registry for England and Wales. Lancet. 2014;384(9952):1437–45. doi:10.​1016/​S0140-6736(14)60419-0.CrossRefPubMed
29.
go back to reference Hunt LP, Ben-Shlomo Y, Clark EM, Dieppe P, Judge A, MacGregor AJ, et al. 45-day mortality after 467,779 knee replacements for osteoarthritis from the National Joint Registry for England and Wales: an observational study. Lancet. 2014;384(9952):1429–36. doi:10.1016/S0140-6736(14)60540-7.CrossRefPubMed Hunt LP, Ben-Shlomo Y, Clark EM, Dieppe P, Judge A, MacGregor AJ, et al. 45-day mortality after 467,779 knee replacements for osteoarthritis from the National Joint Registry for England and Wales: an observational study. Lancet. 2014;384(9952):1429–36. doi:10.​1016/​S0140-6736(14)60540-7.CrossRefPubMed
30.
go back to reference Hunt LP, Ben-Shlomo Y, Clark EM, Dieppe P, Judge A, MacGregor AJ, et al. 90-day mortality after 409,096 total hip replacements for osteoarthritis, from the National Joint Registry for England and Wales: a retrospective analysis. Lancet. 2013;382(9898):1097–104. doi:10.1016/S0140-6736(13)61749-3.CrossRefPubMed Hunt LP, Ben-Shlomo Y, Clark EM, Dieppe P, Judge A, MacGregor AJ, et al. 90-day mortality after 409,096 total hip replacements for osteoarthritis, from the National Joint Registry for England and Wales: a retrospective analysis. Lancet. 2013;382(9898):1097–104. doi:10.​1016/​S0140-6736(13)61749-3.CrossRefPubMed
31.
32.
go back to reference Shimura Y, Kurosawa H, Sugawara Y, Tsuchiya M, Sawa M, Kaneko H, et al. The factors associated with pain severity in patients with knee osteoarthritis vary according to the radiographic disease severity: a cross-sectional study. Osteoarthritis Cartilage. 2013;21(9):1179–84. doi:10.1016/j.joca.2013.05.014.CrossRefPubMed Shimura Y, Kurosawa H, Sugawara Y, Tsuchiya M, Sawa M, Kaneko H, et al. The factors associated with pain severity in patients with knee osteoarthritis vary according to the radiographic disease severity: a cross-sectional study. Osteoarthritis Cartilage. 2013;21(9):1179–84. doi:10.​1016/​j.​joca.​2013.​05.​014.CrossRefPubMed
33.
go back to reference Pisters MF, Veenhof C, van Dijk GM, Dekker J, Group CS. Avoidance of activity and limitations in activities in patients with osteoarthritis of the hip or knee: a 5 year follow-up study on the mediating role of reduced muscle strength. Osteoarthritis Cartilage. 2014;22(2):171–7. doi:10.1016/j.joca.2013.12.007.CrossRefPubMed Pisters MF, Veenhof C, van Dijk GM, Dekker J, Group CS. Avoidance of activity and limitations in activities in patients with osteoarthritis of the hip or knee: a 5 year follow-up study on the mediating role of reduced muscle strength. Osteoarthritis Cartilage. 2014;22(2):171–7. doi:10.​1016/​j.​joca.​2013.​12.​007.CrossRefPubMed
34.
go back to reference Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Omori G, et al. Prevalence of knee pain, lumbar pain and its coexistence in Japanese men and women: the Longitudinal Cohorts of Motor System Organ (LOCOMO) study. J Bone Miner Metab. 2014;32(5):524–32. doi:10.1007/s00774-013-0522-1.CrossRefPubMed Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Omori G, et al. Prevalence of knee pain, lumbar pain and its coexistence in Japanese men and women: the Longitudinal Cohorts of Motor System Organ (LOCOMO) study. J Bone Miner Metab. 2014;32(5):524–32. doi:10.​1007/​s00774-013-0522-1.CrossRefPubMed
36.
go back to reference Rahman MM, Kopec JA, Anis AH, Cibere J, Goldsmith CH. Risk of cardiovascular disease in patients with osteoarthritis: a prospective longitudinal study. Arthritis Care Res (Hoboken). 2013;65(12):1951–8. doi:10.1002/acr.22092.CrossRef Rahman MM, Kopec JA, Anis AH, Cibere J, Goldsmith CH. Risk of cardiovascular disease in patients with osteoarthritis: a prospective longitudinal study. Arthritis Care Res (Hoboken). 2013;65(12):1951–8. doi:10.​1002/​acr.​22092.CrossRef
38.
go back to reference Ishijima M, Watari T, Naito K, Kaneko H, Futami I, Yoshimura-Ishida K, et al. Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis. Arthritis Res Ther. 2011;13(1):R22. doi:10.1186/ar3246.CrossRefPubMedPubMedCentral Ishijima M, Watari T, Naito K, Kaneko H, Futami I, Yoshimura-Ishida K, et al. Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis. Arthritis Res Ther. 2011;13(1):R22. doi:10.​1186/​ar3246.CrossRefPubMedPubMedCentral
40.
go back to reference Sakamoto Y, Ishijima M, Kaneko H, Kurebayashi N, Ichikawa N, Futami I, et al. Distinct mechanosensitive Ca2 + influx mechanisms in human primary synovial fibroblasts. J Orthop Res. 2010;28(7):859–64. doi:10.1002/jor.21080.PubMed Sakamoto Y, Ishijima M, Kaneko H, Kurebayashi N, Ichikawa N, Futami I, et al. Distinct mechanosensitive Ca2 + influx mechanisms in human primary synovial fibroblasts. J Orthop Res. 2010;28(7):859–64. doi:10.​1002/​jor.​21080.PubMed
44.
go back to reference Ayral X, Pickering EH, Woodworth TG, Mackillop N, Dougados M. Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis—results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage. 2005;13(5):361–7.CrossRefPubMed Ayral X, Pickering EH, Woodworth TG, Mackillop N, Dougados M. Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis—results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage. 2005;13(5):361–7.CrossRefPubMed
50.
go back to reference Felson DT, Goggins J, Niu JB, Zhang YQ, Hunter DJ. The effect of body weight on progression of knee osteoarthritis is dependent on alignment. Arthritis Rheum. 2004;50(12):3904–9. doi:10.1002/Art.20726.CrossRefPubMed Felson DT, Goggins J, Niu JB, Zhang YQ, Hunter DJ. The effect of body weight on progression of knee osteoarthritis is dependent on alignment. Arthritis Rheum. 2004;50(12):3904–9. doi:10.​1002/​Art.​20726.CrossRefPubMed
52.
go back to reference Henriksen M, Aaboe J, Bliddal H. The relationship between pain and dynamic knee joint loading in knee osteoarthritis varies with radiographic disease severity. A cross sectional study. Knee. 2012;19(4):392–8.CrossRefPubMed Henriksen M, Aaboe J, Bliddal H. The relationship between pain and dynamic knee joint loading in knee osteoarthritis varies with radiographic disease severity. A cross sectional study. Knee. 2012;19(4):392–8.CrossRefPubMed
53.
go back to reference Liu L, Ishijima M, Futami I, Kaneko H, Kubota M, Kawasaki T, et al. Correlation between synovitis detected on enhanced-magnetic resonance imaging and a histological analysis with a patient-oriented outcome measure for Japanese patients with end-stage knee osteoarthritis receiving joint replacement surgery. Clin Rheumatol. 2010;29(10):1185–90.CrossRefPubMed Liu L, Ishijima M, Futami I, Kaneko H, Kubota M, Kawasaki T, et al. Correlation between synovitis detected on enhanced-magnetic resonance imaging and a histological analysis with a patient-oriented outcome measure for Japanese patients with end-stage knee osteoarthritis receiving joint replacement surgery. Clin Rheumatol. 2010;29(10):1185–90.CrossRefPubMed
54.
go back to reference Ning L, Ishijima M, Kaneko H, Kurihara H, Arikawa-Hirasawa E, Kubota M, et al. Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis. Int Orthop. 2011;35(6):831–8.CrossRefPubMed Ning L, Ishijima M, Kaneko H, Kurihara H, Arikawa-Hirasawa E, Kubota M, et al. Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis. Int Orthop. 2011;35(6):831–8.CrossRefPubMed
55.
go back to reference Yusup A, Kaneko H, Liu L, Ning L, Sadatsuki R, Hada S, et al. Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee osteoarthritis: a cross-sectional study. Osteoarthritis Cartilage. 2015;23(11):1858–64. doi:10.1016/j.joca.2015.05.017.CrossRefPubMed Yusup A, Kaneko H, Liu L, Ning L, Sadatsuki R, Hada S, et al. Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee osteoarthritis: a cross-sectional study. Osteoarthritis Cartilage. 2015;23(11):1858–64. doi:10.​1016/​j.​joca.​2015.​05.​017.CrossRefPubMed
56.
go back to reference Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, et al. Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study. Osteoarthritis Cartilage. 2012;20(11):1217–26. doi:10.1016/j.joca.2012.06.006.CrossRefPubMed Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, et al. Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study. Osteoarthritis Cartilage. 2012;20(11):1217–26. doi:10.​1016/​j.​joca.​2012.​06.​006.CrossRefPubMed
59.
go back to reference Lee J, Chang RW, Ehrlich-Jones L, Kwoh CK, Nevitt M, Semanik PA, et al. Sedentary behavior and physical function: objective evidence from the osteoarthritis initiative. Arthritis Care Res (Hoboken). 2015;67(3):366–73. doi:10.1002/acr.22432.CrossRef Lee J, Chang RW, Ehrlich-Jones L, Kwoh CK, Nevitt M, Semanik PA, et al. Sedentary behavior and physical function: objective evidence from the osteoarthritis initiative. Arthritis Care Res (Hoboken). 2015;67(3):366–73. doi:10.​1002/​acr.​22432.CrossRef
61.
go back to reference Felson DT. Epidemiology of osteoarthritis. In: Brandt KD, Doherty M, Lohmander LS, editors. Osteoarthritis. Oxford: Oxford University Press; 2003. p. 9–16. Felson DT. Epidemiology of osteoarthritis. In: Brandt KD, Doherty M, Lohmander LS, editors. Osteoarthritis. Oxford: Oxford University Press; 2003. p. 9–16.
63.
go back to reference Driban JB, Eaton CB, Lo GH, Ward RJ, Lu B, McAlindon TE. Association of knee injuries with accelerated knee osteoarthritis progression: data from the osteoarthritis initiative. Arthritis Care Res (Hoboken). 2014;66(11):1673–9. doi:10.1002/acr.22359.CrossRef Driban JB, Eaton CB, Lo GH, Ward RJ, Lu B, McAlindon TE. Association of knee injuries with accelerated knee osteoarthritis progression: data from the osteoarthritis initiative. Arthritis Care Res (Hoboken). 2014;66(11):1673–9. doi:10.​1002/​acr.​22359.CrossRef
64.
go back to reference Prieto-Alhambra D, Nogues X, Javaid MK, Wyman A, Arden NK, Azagra R, et al. An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW). Ann Rheum Dis. 2013;72(6):911–7. doi:10.1136/annrheumdis-2012-201451.CrossRefPubMed Prieto-Alhambra D, Nogues X, Javaid MK, Wyman A, Arden NK, Azagra R, et al. An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW). Ann Rheum Dis. 2013;72(6):911–7. doi:10.​1136/​annrheumdis-2012-201451.CrossRefPubMed
67.
go back to reference Mosher TJ, Liu Y, Yang QX, Yao J, Smith R, Dardzinski BJ, et al. Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women. Arthritis Rheum. 2004;50(9):2820–8. doi:10.1002/art.20473.CrossRefPubMed Mosher TJ, Liu Y, Yang QX, Yao J, Smith R, Dardzinski BJ, et al. Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women. Arthritis Rheum. 2004;50(9):2820–8. doi:10.​1002/​art.​20473.CrossRefPubMed
68.
go back to reference Hada S, Kaneko H, Sadatsuki R, Liu L, Futami I, Kinoshita M, et al. The degeneration and destruction of femoral articular cartilage shows a greater degree of deterioration than that of the tibial and patellar articular cartilage in early stage knee osteoarthritis: a cross-sectional study. Osteoarthritis Cartilage. 2014;22(10):1583–9. doi:10.1016/j.joca.2014.07.021.CrossRefPubMed Hada S, Kaneko H, Sadatsuki R, Liu L, Futami I, Kinoshita M, et al. The degeneration and destruction of femoral articular cartilage shows a greater degree of deterioration than that of the tibial and patellar articular cartilage in early stage knee osteoarthritis: a cross-sectional study. Osteoarthritis Cartilage. 2014;22(10):1583–9. doi:10.​1016/​j.​joca.​2014.​07.​021.CrossRefPubMed
70.
71.
go back to reference Berthiaume MJ, Raynauld JP, Martel-Pelletier J, Labonte F, Beaudoin G, Bloch DA, et al. Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging. Ann Rheum Dis. 2005;64(4):556–63. doi:10.1136/ard.2004.023796.CrossRefPubMed Berthiaume MJ, Raynauld JP, Martel-Pelletier J, Labonte F, Beaudoin G, Bloch DA, et al. Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging. Ann Rheum Dis. 2005;64(4):556–63. doi:10.​1136/​ard.​2004.​023796.CrossRefPubMed
72.
go back to reference Sharma L, Eckstein F, Song J, Guermazi A, Prasad P, Kapoor D, et al. Relationship of meniscal damage, meniscal extrusion, malalignment, and joint laxity to subsequent cartilage loss in osteoarthritic knees. Arthritis Rheum. 2008;58(6):1716–26. doi:10.1002/art.23462.CrossRefPubMed Sharma L, Eckstein F, Song J, Guermazi A, Prasad P, Kapoor D, et al. Relationship of meniscal damage, meniscal extrusion, malalignment, and joint laxity to subsequent cartilage loss in osteoarthritic knees. Arthritis Rheum. 2008;58(6):1716–26. doi:10.​1002/​art.​23462.CrossRefPubMed
73.
go back to reference Kawaguchi K, Enokida M, Otsuki R, Teshima R. Ultrasonographic evaluation of medial radial displacement of the medial meniscus in knee osteoarthritis. Arthritis Rheum. 2012;64(1):173–80. doi:10.1002/art.33319.CrossRefPubMed Kawaguchi K, Enokida M, Otsuki R, Teshima R. Ultrasonographic evaluation of medial radial displacement of the medial meniscus in knee osteoarthritis. Arthritis Rheum. 2012;64(1):173–80. doi:10.​1002/​art.​33319.CrossRefPubMed
74.
go back to reference Hunter DJ, Zhang YQ, Niu JB, Tu X, Amin S, Clancy M, et al. The association of meniscal pathologic changes with cartilage loss in symptomatic knee osteoarthritis. Arthritis Rheum. 2006;54(3):795–801. doi:10.1002/art.21724.CrossRefPubMed Hunter DJ, Zhang YQ, Niu JB, Tu X, Amin S, Clancy M, et al. The association of meniscal pathologic changes with cartilage loss in symptomatic knee osteoarthritis. Arthritis Rheum. 2006;54(3):795–801. doi:10.​1002/​art.​21724.CrossRefPubMed
75.
go back to reference Raynauld JP, Martel-Pelletier J, Berthiaume MJ, Beaudoin G, Choquette D, Haraoui B, et al. Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes. Arthritis Res Ther. 2006;8(1):R21. doi:10.1186/ar1875.CrossRefPubMed Raynauld JP, Martel-Pelletier J, Berthiaume MJ, Beaudoin G, Choquette D, Haraoui B, et al. Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes. Arthritis Res Ther. 2006;8(1):R21. doi:10.​1186/​ar1875.CrossRefPubMed
77.
go back to reference Bloecker K, Wirth W, Guermazi A, Hunter DJ, Resch H, Hochreiter J, et al. Relationship between medial meniscal extrusion and cartilage loss in specific femorotibial subregions: data from the osteoarthritis initiative. Arthritis Care Res (Hoboken). 2015;67(11):1545–52. doi:10.1002/acr.22615.CrossRef Bloecker K, Wirth W, Guermazi A, Hunter DJ, Resch H, Hochreiter J, et al. Relationship between medial meniscal extrusion and cartilage loss in specific femorotibial subregions: data from the osteoarthritis initiative. Arthritis Care Res (Hoboken). 2015;67(11):1545–52. doi:10.​1002/​acr.​22615.CrossRef
Metadata
Title
Osteoarthritis as a Cause of Locomotive Syndrome: Its Influence on Functional Mobility and Activities of Daily Living
Authors
Muneaki Ishijima
Haruka Kaneko
Shinnosuke Hada
Mayuko Kinoshita
Ryo Sadatsuki
Lizu Liu
Yukio Shimura
Hitoshi Arita
Jun Shiozawa
Anwarjan Yusup
Ippei Futami
Yuko Sakamoto
Masayoshi Ishibashi
Syuichi Machida
Hisashi Naito
Eri Arikawa-Hirasawa
Chieko Hamada
Yoshitomo Saita
Yuji Takazawa
Hiroshi Ikeda
Yasunori Okada
Kazuo Kaneko
Publication date
01-06-2016
Publisher
Springer US
Published in
Clinical & Translational Metabolism / Issue 2/2016
Print ISSN: 1534-8644
Electronic ISSN: 2948-2445
DOI
https://doi.org/10.1007/s12018-016-9212-6

Other articles of this Issue 2/2016

Clinical Reviews in Bone and Mineral Metabolism 2/2016 Go to the issue

Locomotive Syndrome

Introduction

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.