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BMC Oral Health
Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | Oropharyngeal Cancer | Research

Causal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization study

Authors: Weixing Liu, Yue Liu, Pei Li, Zhiyuan Wang, Jia Chen, Hui Liu, Jin Ye

Published in: BMC Oral Health | Issue 1/2023

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Abstract

Background

Observational epidemiological studies revealed that multiple serum biomarkers can be associated with the risk of oral and oropharyngeal cancer (OC/OPC). However, the causal relationship between them remains largely unknown. This study aimed to investigate the causal relationship between potential serum biomarkers and (OC/OPC).

Methods

A two-sample Mendelian randomization (MR) approach was performed to assess the causal association of 10 serum biomarkers with the risk of OC / OPC. Summary data on OC/OPC were obtained from a GWAS meta-analysis that included 2497 cases and 2928 controls. The TwoSampleMR package in R was used to perform MR analyzes. Inverse-variance weighted (IVW), Weighted median and MR-Egger methods were used to assess causal effects.

Results

Suggestive associations with increased risk of C-reactive protein (CRP) (OR 1.52, 95% CI 1.14 to 2.02), using the IVW method. MR-Egger regression suggested that directional pleiotropy was unlikely to bias the result (P = 0.19). The findings were robust to sensitivity analyzes. The risk of OC/OPC was not associated with serum 25-hydroxyvitamin D, HDL cholesterol, LDL cholesterol, total cholesterol, triglycerides, adiponectin, leptin, HbA1C and Insulin-like growth factor 1 (IGF 1).

Conclusions

This study supports that CRP was causally associated with an increased risk of oral and oropharyngeal cancer.
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Metadata
Title
Causal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization study
Authors
Weixing Liu
Yue Liu
Pei Li
Zhiyuan Wang
Jia Chen
Hui Liu
Jin Ye
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-03729-x

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