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Open Access 01-12-2019 | Immunology, Transplantation, and Regenerative Medicine (L Piemonti and V Sordi, Section Editors)

Organoids from the Human Fetal and Adult Pancreas

Authors: Jeetindra R. A. Balak, Juri Juksar, Françoise Carlotti, Antonio Lo Nigro, Eelco J. P. de Koning

Published in: Current Diabetes Reports | Issue 12/2019

Abstract

Purpose of Review

Novel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue–derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine.

Recent Findings

Organoids derived from human fetal and adult pancreatic tissue have been used to study pancreas development and repair. Generated adult human pancreatic organoids harbor the capacity for clonal expansion and endocrine cell formation. In addition, organoids have been generated from human pancreatic ductal adenocarcinoma in order to study tumor behavior and assess drug responses.

Summary

Pancreatic organoids constitute an important translational bridge between in vitro and in vivo models, enhancing our understanding of pancreatic cell biology. Current applications for pancreatic organoid technology include studies on tissue regeneration, disease modelling, and drug screening.

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Title: Organoids from the Human Fetal and Adult Pancreas
Authors: Jeetindra R. A. Balak
Juri Juksar
Françoise Carlotti
Antonio Lo Nigro
Eelco J. P. de Koning
Publication date: 01-12-2019
Publisher: Springer US
Published in: Current Diabetes Reports / Issue 12/2019
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI: https://doi.org/10.1007/s11892-019-1261-z

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