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Japanese Journal of Radiology
Published in: Japanese Journal of Radiology 10/2017

01-10-2017 | Original Article

Organ retention of gadolinium in mother and pup mice: effect of pregnancy and type of gadolinium-based contrast agents

Authors: Khongorzul Erdene, Takahito Nakajima, Satomi Kameo, Miski Aghnia Khairinisa, Oyunbold Lamid-Ochir, Amartuvshin Tumenjargal, Noriyuki Koibuchi, Hiroshi Koyama, Yoshito Tsushima

Published in: Japanese Journal of Radiology | Issue 10/2017

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Abstract

Purpose

To investigate the effect of pregnancy and type of gadolinium (Gd)-based contrast agents (GBCAs) on organ retention of Gd in mother and pup mice after maternal administration.

Materials and methods

Gd-DTPA-BMA (gadodiamide) or Gd-DOTA (gadoterate dimeglumine) was administered (2.0 mmol/kg of maternal weight) four times to pregnant Balb/c mice from gestational day 16–19, respectively. At 28 days after birth, they were euthanized and their organs (blood, brain, liver, kidney, spleen, and bone) were removed for the measurement of Gd by inductively coupled plasma mass spectrometry.

Results

Gd retention in maternal organs was generally lower than that in the organs of non-pregnant mice in both Gd-DTPA-BMA and Gd-DOTA groups. Significantly higher Gd retention was observed in the organs of pups whose mothers were administered Gd-DTPA-BMA as compared to those whose mothers were administered Gd-DOTA. Tissue-to-muscle ratio in the brains of pups was higher than that of mothers.

Conclusion

We demonstrated in utero transplacental Gd retention in pups. In various organs in both mothers and pups, Gd retention was consistently higher for Gd-DTPA-BMA than Gd-DOTA administration. Pregnancy affected Gd retention in many maternal organs.
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Metadata
Title
Organ retention of gadolinium in mother and pup mice: effect of pregnancy and type of gadolinium-based contrast agents
Authors
Khongorzul Erdene
Takahito Nakajima
Satomi Kameo
Miski Aghnia Khairinisa
Oyunbold Lamid-Ochir
Amartuvshin Tumenjargal
Noriyuki Koibuchi
Hiroshi Koyama
Yoshito Tsushima
Publication date
01-10-2017
Publisher
Springer Japan
Published in
Japanese Journal of Radiology / Issue 10/2017
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-017-0667-2

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