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Head & Neck Oncology
Published in: Head & Neck Oncology 1/2011

Open Access 01-12-2011 | Review

Oral squamous cell cancer: early detection and the role of alcohol and smoking

Authors: Anna G Zygogianni, George Kyrgias, Petros Karakitsos, Amanta Psyrri, John Kouvaris, Nikolaos Kelekis, Vassilis Kouloulias

Published in: Head & Neck Oncology | Issue 1/2011

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Abstract

Objective

Oral squamous cell carcinoma has a remarkable incidence worldwide and a fairly onerous prognosis, encouraging further research on factors that might modify disease outcome.

Data sources

A web-based search for all types of articles published was initiated using Medline/Pub Med, with the key words such as oral cancer, alcohol consumption, genetic polymorphisms, tobacco smoking and prevention. The search was restricted to articles published in English, with no publication date restriction (last update 2010).

Review Methods

In this review article, we approach the factors for a cytologic diagnosis during OSCC development and the markers used in modern diagnostic technologies as well. We also reviewed available studies of the combined effects of alcohol drinking and genetic polymorphisms on alcohol-related cancer risk.

Results

The interaction of smoking and alcohol significantly increases the risk for aero-digestive cancers. The interaction between smoking and alcohol consumption seems to be responsible for a significant amount of disease.

Conclusion

Published scientific data show promising pathways for the future development of more effective prognosis. There is a clear need for new prognostic indicators, which could be used in diagnostics and, therefore a better selection of the most effective treatment can be achieved.
Appendix
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Metadata
Title
Oral squamous cell cancer: early detection and the role of alcohol and smoking
Authors
Anna G Zygogianni
George Kyrgias
Petros Karakitsos
Amanta Psyrri
John Kouvaris
Nikolaos Kelekis
Vassilis Kouloulias
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Head & Neck Oncology / Issue 1/2011
Electronic ISSN: 1758-3284
DOI
https://doi.org/10.1186/1758-3284-3-2

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