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Journal of Cancer Research and Clinical Oncology

Published in:

01-07-2009 | Original Paper

Down-regulation of plasma membranous Annexin A1 protein expression in premalignant and malignant lesions of the oral cavity: correlation with epithelial differentiation

Authors: Hitomi Nomura, Katsuhiro Uzawa, Yukio Yamano, Kazuaki Fushimi, Dai Nakashima, Yukinao Kouzu, Atsushi Kasamatsu, Katsunori Ogawara, Masashi Shiiba, Hiroki Bukawa, Hidetaka Yokoe, Hideki Tanzawa

Published in: Journal of Cancer Research and Clinical Oncology | Issue 7/2009

Abstract

Purpose

To determine the potential involvement of ANXA1 in oral squamous-cell carcinoma (OSCC), we evaluated the ANXA1 protein expression in oral premalignant lesions (OPLs) and OSCCs and correlated the results with clinicopathologic variables.

Methods

Matched normal and tumour specimens of 44 primary OSCCs and 28 OPLs were analyzed for ANXA1 subcellular localization and protein expression level by immunohistochemistry (IHC). Correlations between ANXA1-IHC staining scores of OSCCs and clinicopathologic features were evaluated by Fisher’s exact test.

Results

Markedly down-regulation of ANXA1 protein expression was identified on the plasma membrane of epithelial cells in OSCCs (P < 0.001) and OPLs (P = 0.001) compared with normal counterparts. Moreover, loss of plasma membranous ANXA1 expression was significantly correlated with the poorly differentiated status of OSCC cells (P = 0.012).

Conclusions

Our findings suggest that loss of ANXA1 is frequent and early event during oral carcinogenesis and that ANXA1 could contribute to maintaining epithelial differentiation in OSCC.

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Title: Down-regulation of plasma membranous Annexin A1 protein expression in premalignant and malignant lesions of the oral cavity: correlation with epithelial differentiation
Authors: Hitomi Nomura
Katsuhiro Uzawa
Yukio Yamano
Kazuaki Fushimi
Dai Nakashima
Yukinao Kouzu
Atsushi Kasamatsu
Katsunori Ogawara
Masashi Shiiba
Hiroki Bukawa
Hidetaka Yokoe
Hideki Tanzawa
Publication date: 01-07-2009
Publisher: Springer-Verlag
Published in: Journal of Cancer Research and Clinical Oncology / Issue 7/2009
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-008-0530-z

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Down-regulation of plasma membranous Annexin A1 protein expression in premalignant and malignant lesions of the oral cavity: correlation with epithelial differentiation

Abstract

Purpose

Methods

Results

Conclusions

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