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Critical Care
Published in: Critical Care 1/2007

01-02-2007 | Letter

Oral decontamination with chlorhexidine reduces the incidence of nosocomial pneumonia

Authors: Ilias I Siempos, Matthew E Falagas

Published in: Critical Care | Issue 1/2007

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Excerpt

Pineda and colleagues [1] published a well-performed meta-analysis of four randomized controlled trials (RCTs) [2‐5] exploring the effect of oral chlorhexidine (CHX) application on the incidence of nosocomial pneumonia (NP) in mechanically ventilated patients. They concluded that oral CHX decontamination did not reduce the incidence of NP in such patients; however, they clearly stated that the combined sample size of the four RCTs included may be inadequate for detecting important differences. Meanwhile, additional important data on this issue have been published; updating the findings of the above meta-analysis [1] is therefore warranted. …
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Literature
1.
Pineda LA, Saliba RG, El Solh AA: Effect of oral decontamination with chlorhexidine on the incidence of nosocomial pneumonia: a meta-analysis. Crit Care 2006, 10: R35. 10.1186/cc4837PubMedCentralCrossRefPubMed
2.
DeRiso A, Ladowski J, Dillon T, Justice J, Peterson A: Chlorhexidine gluconate 0.12% oral rinse reduces the incidence of total nosocomial respiratory infection and nonprophylactic systemic antibiotic use in patients undergoing heart surgery. Chest 1996, 109: 1556-1561.CrossRefPubMed
3.
Fourrier F, Cau-Pottier E, Boutigny H, Roussel-Delvallez M, Jourdain M, Chopin C: Effects of dental plaque antiseptic decontamination on bacterial colonization and nosocomial infections in critically ill patients. Intensive Care Med 2000, 26: 1239-1247. 10.1007/s001340000585CrossRefPubMed
4.
Fourrier F, Dubois D, Pronnier P, Herbecq P, Leroy O, Desmettre T, Pottier-Cau E, Boutigny H, Di Pompeo C, Durocher A, Roussel-Delvallez M, for the PIRAD Study Group: Effect of gingival and dental plaque antiseptic decontamination on nosocomial infections acquired in the intensive care unit: a double-blind placebo controlled multicenter study. Crit Care Med 2005, 33: 1728-1735. 10.1097/01.CCM.0000171537.03493.B0CrossRefPubMed
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Houston S, Hougland P, Anderson J, LaRocco M, Kennedy V, Gentry L: Effectiveness of 0.12% chlorhexidine gluconate oral rinse in reducing prevalence of nosocomial pneumonia in patients undergoing heart surgery. Am J Crit Care 2002, 11: 567-570.PubMed
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Koeman M, van der Ven AJ, Hak E, Joore HC, Kaasjager K, de Smet AG, Ramsay G, Dormans TP, Aarts LP, de Bel EE, et al.: Oral decontamination with chlorhexidine reduces the incidence of ventilator-associated pneumonia. Am J Respir Crit Care Med 2006, 173: 1348-1355. 10.1164/rccm.200505-820OCCrossRefPubMed
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Bopp M, Darby M, Loftin KC, Broscious S: Effects of daily oral care with 0.12% chlorhexidine gluconate and a standard oral care protocol on the development of nosocomial pneumonia in intubated patients: a pilot study. J Dent Hyg 2006,80(9):1-10.
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Lau J, Ioannidis JPA, Schmid CH: Quantitative synthesis. In Systematic reviews: synthesis of best evidence for health care decisions. Edited by: Mulrow CD, Cook D. Philadelphia: American College of Physicians; 1998:91-101.
Metadata
Title
Oral decontamination with chlorhexidine reduces the incidence of nosocomial pneumonia
Authors
Ilias I Siempos
Matthew E Falagas
Publication date
01-02-2007
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2007
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc5129

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