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BMC Oral Health
Published in: BMC Oral Health 1/2021

Open Access 01-12-2021 | Oral Cancer | Research article

The burden of oral cancer in China, 1990–2017: an analysis for the Global Burden of Disease, Injuries, and Risk Factors Study 2017

Authors: Yang Yang, Maigeng Zhou, Xinying Zeng, Chunxiao Wang

Published in: BMC Oral Health | Issue 1/2021

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Abstract

Background

Oral cancer is among the most common malignant tumors worldwide, and it has become an increasingly important public health problem in China. This study systematically assesses the current state of oral cancer in China from 1990 to 2017, providing new information and perspectives for oral health researchers and public health policy makers.

Methods

Based on the Global Burden of Disease, Injuries, and Risk Factors Study 2017 (GBD 2017), we evaluated the incidence rates, mortality and disability-adjusted life year (DALY) rates for oral cancer in China and their changing trends between 1990 and 2017, making comparisons by gender and age. We also assessed the DALY rates associated with oral cancer at the provincial level for 33 provinces and their trends over time.

Results

From 1990 to 2017, the number of new cases and the age-standardized incidence rate for oral cancer in China increased by 280.0% and 79.7%, respectively; the number of deaths and the age-standardized mortality rose by 196.8% and 29.0%, respectively; and the number of DALYs and the age-standardized DALY rate increased by 149.1% and 21.0%, respectively. The incidence rates for oral cancer rose after 30 years of age and peaked at 65–69 years; the mortality for oral cancer rose after 50 years of age and peaked at 65–69 years; and the DALY rates for oral cancer rose after 45 years of age and peaked at 65–69 years. The incidence rates, mortality and DALY rates for oral cancer in males were significantly higher than those in females and showed an upward trend, while there was a decrease or no significant change in females. The DALY rates increased in 21 provinces and decreased in 12 provinces, with the largest growth in Henan Province and the largest decline in Hong Kong Province.

Conclusions

The burden of oral cancer in China continues to increase continuously. More prevention, control and intervention measures should be taken and increased attention paid to common risk factors is essential for the prevention of oral cancer.
Literature
1.
Zhang LW, Li J, Cong X, Hu XS, Li D, Wu LL, Hua H, Yu GY, Kerr AR. Incidence and mortality trends in oral and oropharyngeal cancers in China, 2005–2013. Cancer Epidemiol. 2018;57:120–6.PubMedCrossRef
2.
Dhanuthai K, Rojanawatsirivej S, Thosaporn W, Kintarak S, Subarnbhesaj A, Darling M, Kryshtalskyj E, Chiang CP, Shin HI, Choi SY, et al. Oral cancer: A multicenter study. Med Oral Patol Oral Cir Bucal. 2018;23(1):e23–9.PubMed
3.
Rao SVK, Mejia G, Roberts-Thomson K, Logan R. Epidemiology of oral cancer in Asia in the past decade—an update (2000–2012). Asian Pac J Cancer Prev. 2013;14(10):5567–77.CrossRef
4.
Shield KD, Ferlay J, Jemal A, Sankaranarayanan R, Chaturvedi AK, Bray F, Soerjomataram I. The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin. 2017;67(1):51–64.PubMedCrossRef
5.
Xia B, Hong T, He X, Hu XL, Gao YB. A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability. Cell Transplant. 2019;28(12):1614–23.PubMedPubMedCentralCrossRef
6.
Zeng HM, Chen WQ, Zheng RS, Zhang S, Wei JJS, Zou XN, Xia CF, Sun KX, Yang ZX, Li H, et al. Changing cancer survival in China during 2003–15: a pooled analysis of 17 population-based cancer registries. Lancet Glob Health. 2018;6(5):e555–67.PubMedCrossRef
7.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.PubMedCrossRef
8.
Gupta B, Johnson NW, Kumar N. Global epidemiology of head and neck cancers: a continuing challenge. Oncology. 2016;91(1):13–23.PubMedCrossRef
9.
Lei L, Zheng R, Peng K, Si L, Peng J, Cai W, Zhang S, Wei W, He J. Incidence and mortality of oral and oropharyngeal cancer in China, 2015. Chin J Cancer Res. 2020;32(1):1–9.PubMedPubMedCentralCrossRef
10.
Chen WQ, Zheng RS, Baade PD, Zhang SW, Zeng HM, Bray F, Jemal A, Yu XQ, He J. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–32.PubMedCrossRef
11.
Lee YA, Li S, Chen Y, Li Q, Chen CJ, Hsu WL, Lou PJ, Zhu C, Pan J, Shen H, et al. Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population. Head Neck. 2019;41(1):92–102.PubMed
12.
13.
Li YR, Wang J, Zhao LY, Wang ZH, Yu DM, He YN, Ding GQ. The drinking status and associated factors in adults in China. Chin J Epidemiol. 2018;39(7):898–903.
14.
Zhang XL, Reichart PA. A review of betel quid chewing, oral cancer and precancer in Mainland China. Oral Oncol. 2007;43(5):424–30.PubMedCrossRef
15.
James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, Abbastabar H, Abd-Allah F, Abdela J, Abdelalim A, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1789–858.CrossRef
16.
Dicker D, Nguyen G, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, Abbastabar H, Abd-Allah F, Abdela J, et al. Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1684–735.CrossRef
17.
Roth GA, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, Abbastabar H, Abd-Allah F, Abdela J, Abdelalim A, et al. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1736–88.CrossRef
18.
Zhou MG, Wang HD, Zeng XY, Yin P, Zhu J, Chen WQ, Li XH, Wang LJ, Wang LM, Liu YN, et al. Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2019;394(10204):1145–58.PubMedPubMedCentralCrossRef
19.
Duan LL, Ye PP, Haagsma JA, Jin Y, Wang Y, Yuliang E, Deng X, Gao X, Ji CR, Wang LH, et al. The burden of injury in China, 1990–2017: findings from the Global Burden of Disease Study 2017. Lancet Public Health. 2019;4(9):e449–61.CrossRef
20.
Kyu HH, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, Abbastabar H, Abd-Allah F, Abdela J, Abdelalim A, et al. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1859–922.CrossRef
21.
Murray CJL, Callender CSKH, Kulikoff XR, Srinivasan V, Abate D, Abate KH, Abay SM, Abbasi N, Abbastabar H, Abdela J, et al. Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1995–2051.CrossRef
22.
Stanaway JD, Afshin A, Gakidou E, Lim SS, Abate D, Abate KH, Abbafati C, Abbasi N, Abbastabar H, Abd-Allah F, et al. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1923–94.CrossRef
23.
24.
Stevens GA, Alkema L, Black RE, Boerma JT, Collins GS, Ezzati M, Grove JT, Hogan DR, Hogan MC, Horton R, et al. Guidelines for Accurate And Transparent Health Estimates Reporting: The GATHER statement. PLoS Med. 2016;13(6):e1002056.PubMedPubMedCentralCrossRef
25.
Gouda HN, Charlson F, Sorsdahl K, Ahmadzada S, Ferrari AJ, Erskine H, Leung J, Santamauro D, Lund C, Aminde LN, et al. Burden of non-communicable diseases in sub-Saharan Africa, 1990–2017: results from the Global Burden of Disease Study 2017. Lancet Glob Health. 2019;7(10):e1375–87.PubMedCrossRef
26.
Du M, Nair R, Jamieson L, Liu Z, Bi P. Incidence trends of lip, oral cavity, and pharyngeal cancers: global burden of disease 1990–2017. J Dent Res. 2020;99(2):143–51.PubMedCrossRef
27.
Hung LC, Kung PT, Lung CH, Tsai MH, Liu SA, Chiu LT, Huang KH, Tsai WC. Assessment of the risk of oral cancer incidence in a high-risk population and establishment of a predictive model for oral cancer incidence using a population-based cohort in Taiwan. Int J Environ Res Public Health. 2020;17(2):665.PubMedCentralCrossRef
28.
Zhou MG, Wang HD, Zhu J, Chen WQ, Wang LH, Liu SW, Li YC, Wang LJ, Liu YM, Yin P, et al. Cause-specific mortality for 240 causes in China during 1990–2013: a systematic subnational analysis for the Global Burden of Disease Study 2013. Lancet. 2016;387(10015):251–72.PubMedCrossRef
29.
Yang TZ, Barnett R, Rockett IRH, Yang XZY, Wu D, Zheng WJ, Li L. The impact of regional economic reliance on the tobacco industry on current smoking in China. Health Place. 2015;33:159–71.PubMedCrossRef
30.
Astell-Burt T, Zhang M, Feng XQ, Wang LM, Li YC, Page A, Zhou MG, Wang LH. Geographical inequality in tobacco control in China: multilevel evidence from 98058 participants. Nicotine Tob Res. 2018;20(6):755–65.PubMedCrossRef
31.
Millwood IY, Walters RG, Mei XW, Guo Y, Yang L, Bian Z, Bennett DA, Chen YP, Dong CX, Hu RY, et al. Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China. Lancet. 2019;393(10183):1831–42.PubMedPubMedCentralCrossRef
32.
Hu YJ, Chen J, Zhong WS, Ling TY, Jian XC, Lu RH, Tang ZG, Tao L. Trend analysis of betel nut-associated oral cancer and health burden in China. Chin J Dent Res. 2017;20(2):69–78.PubMed
33.
Chen WQ, Xia CF, Zheng RS, Zhou MG, Lin CQ, Zeng HM, Zhang SW, Wang LJ, Yang ZX, Sun KX, et al. Disparities by province, age, and sex in site-specific cancer burden attributable to 23 potentially modifiable risk factors in China: a comparative risk assessment. Lancet Glob Health. 2019;7(2):e257–69.PubMedCrossRef
34.
Rao YS, Guo YL, Ge WT, Zhang J, Tai J, Huang YB, Pen XX, Han SJ. Systematic review and meta-analysis on the relationship of smoking with the risk of oral cancer among Chinese population. Chin Arch Otolaryngol Head Neck Surg. 2014;21(10):505–10.
35.
Chinese Center for Disease Control and Prevention. China adult tobacco survey report 2015. People’s Medical Publishing House; 2016.
36.
Lin X, Wu X, Gomaa A, Chen J, Wu L, Xie X, Hu Y, Jiang C. Analysis of risk factors for multiple primary oral squamous cell carcinoma: a cohort study. Clin Oral Investig. 2020;24(9):3147–55.PubMedCrossRef
37.
Madani AH, Dikshit M, Bhaduri D, Aghamolaei T, Moosavy SH, Azarpaykan A. Interaction of alcohol use and specific types of smoking on the development of oral cancer. Int J High Risk Behav Addict. 2014;3(1):e12120.PubMedPubMedCentralCrossRef
38.
Gapstur SM, Drope JM, Jacobs EJ, Teras LR, McCullough ML, Douglas CE, Patel AV, Wender RC, Brawley OW. A blueprint for the primary prevention of cancer: targeting established, modifiable risk factors. CA Cancer J Clin. 2018;68(6):446–70.PubMedCrossRef
39.
Jakob M, Kevin DS, Margaret R, Omer SMH, Charlotte P, Jürgen R. Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study. Lancet. 2019;393(10190):2493–502.CrossRef
40.
World Health Organization. Global status report on alcohol and health 2018. World Health Organization; 2019.
41.
Guha N, Warnakulasuriya S, Vlaanderen J, Straif K. Betel quid chewing and the risk of oral and oropharyngeal cancers: a meta-analysis with implications for cancer control. Int J Cancer. 2014;135(6):1433–43.PubMedCrossRef
42.
Lee CH, Ko AM, Warnakulasuriya S, Yin BL, Sunarjo ZRB, Ibrahim SO, Liu ZW, Li WH, Zhang SS, et al. Intercountry prevalences and practices of betel-quid use in south, southeast and eastern Asia regions and associated oral preneoplastic disorders: an international collaborative study by Asian betel-quid consortium of south and east Asia. Int J Cancer. 2011;129(7):1741–51.PubMedCrossRef
43.
Huang WL, Zhu SL, Zou YH. Incidence and mortality of oral cancer in registered regions of Hunan in 2009–2012. China Cancer. 2017;26(7):507–14.
44.
Hu YN, Zhong R, Li HL, Zou YH. Effects of Betel Quid, Smoking and alcohol on oral cancer risk: a case-control study in Hunan Province. China. Subst Use Misuse. 2020;55(9):1501–8.PubMedCrossRef
45.
Tan XD, Liu XX, Shao HY. Healthy China 2030: a vision for health care. Value Health Reg Issues. 2017;12:112–4.PubMedCrossRef
46.
47.
48.
Metadata
Title
The burden of oral cancer in China, 1990–2017: an analysis for the Global Burden of Disease, Injuries, and Risk Factors Study 2017
Authors
Yang Yang
Maigeng Zhou
Xinying Zeng
Chunxiao Wang
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2021
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-020-01386-y

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