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BMC Oral Health

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01-12-2021 | Lichen Planus | Research

Clinical characteristics of oral lichen planus and its causal context with dental restorative materials and oral health-related quality of life

Authors: Linda Daume, Constance Kreis, Lauren Bohner, Susanne Jung, Johannes Kleinheinz

Published in: BMC Oral Health | Issue 1/2021

Abstract

Background

The aim of this study was to investigate the influence of clinical characteristics and dental restorative materials on oral health-related quality of life in patients with oral lichen planus. In particular, the influences of amalgam and metals were investigated.

Methods

A total of 112 patients with clinical and histological features of oral lichen planus from the Department of Cranio-Maxillofacial Surgery at the University Hospital of Münster participated in this prospective study. Clinical parameters of oral lichen planus and the dental restorative materials used were evaluated. Oral health-related quality of life was investigated by using the short form of the German version of the Oral Health Impact Profile (OHIP-14). In addition, physical pain was rated on a visual analogue scale.

Results

The average OHIP-14 score was 13.54. A high correlation was seen between OHIP and pain. Likewise, higher OHIP-values were seen for male patients, and such as for those patients with non-reticular forms of oral lichen planus (OLP). A local form of OLP is more often seen on female patients, such as with the presence of reticular lichen. In regard to the restorations, the presence of composite restorations is correlated with a local lichen, whereas the presence of gold restorations is often seen with a generalized lichen. Furthermore, the grading of strength of association between mucosal lesion and amalgam/metal was tested. No significant differences revealed the analysis of the relationship between gender, clinical form of OLP, age, and presentation form between the 4 gradings of Thornhill.

Conclusions

The oral health-related quality of life is significantly limited in patients with oral lichen planus. But these OHIP scores are not influenced by the restorative materials. Here, pain severity is the most important aspect. We found no statistical differences in the clinical parameters between patients with amalgam or metal restoration and patients without these restorations. It is not necessary to replace amalgam fillings that are not in direct contact with mucosal surfaces.

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Cervino G, Cicciù M, de Stefano R, Falcomatà D, Bianchi A, Crimi S, et al. Oral health in patients with Marfan syndrome. Arch Oral Biol. 2020;116:104745. https://doi.org/10.1016/j.archoralbio.2020.104745.CrossRefPubMed

Fiorillo L, Cervino G, Laino L, D’Amico C, Mauceri R, Tozum TF, et al. Porphyromonas gingivalis, periodontal and systemic implications: a systematic review. Dent J (Basel). 2019. https://doi.org/10.3390/dj7040114.CrossRef

González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, González-Ruiz L, Ayén Á, Lenouvel D, et al. Worldwide prevalence of oral lichen planus: a systematic review and meta-analysis. Oral Dis. 2020. https://doi.org/10.1111/odi.13323.CrossRefPubMed

Giuliani M, Troiano G, Cordaro M, Corsalini M, Gioco G, Lo Muzio L, et al. Rate of malignant transformation of oral lichen planus: a systematic review. Oral Dis. 2019;25:693–709. https://doi.org/10.1111/odi.12885.CrossRefPubMed

Gupta S, Jawanda MK. Oral lichen planus: an update on etiology, pathogenesis, clinical presentation, diagnosis and management. Indian J Dermatol. 2015;60:222–9. https://doi.org/10.4103/0019-5154.156315.CrossRefPubMedPubMedCentral

Ismail SB, Kumar SKS, Zain RB. Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation. J Oral Sci. 2007;49:89–106. https://doi.org/10.2334/josnusd.49.89.CrossRefPubMed

Lartitegui-Sebastián M-J, Martínez-Revilla B, Saiz-Garcia C, Eguizabal-Saracho S, Aguirre-Urizar J-M. Oral lichenoid lesions associated with amalgam restorations: a prospective pilot study addressing the adult population of the Basque Country. Med Oral Patol Oral Cir Bucal. 2012;17:e545–9. https://doi.org/10.4317/medoral.17733.CrossRefPubMedPubMedCentral

López-Jornet P, Camacho-Alonso F, Gomez-Garcia F, Bermejo FA. The clinicopathological characteristics of oral lichen planus and its relationship with dental materials. Contact Derm. 2004;51:210–1. https://doi.org/10.1111/j.0105-1873.2004.0424a.x.CrossRef

Thornhill MH, Pemberton MN, Simmons RK, Theaker ED. Amalgam-contact hypersensitivity lesions and oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95:291–9. https://doi.org/10.1067/moe.2003.115.CrossRefPubMed

10.

Issa Y, Brunton PA, Glenny AM, Duxbury AJ. Healing of oral lichenoid lesions after replacing amalgam restorations: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:553–65. https://doi.org/10.1016/j.tripleo.2003.12.027.CrossRefPubMed

11.

Dunsche A, Kästel I, Terheyden H, Springer ING, Christophers E, Brasch J. Oral lichenoid reactions associated with amalgam: improvement after amalgam removal. Br J Dermatol. 2003;148:70–6. https://doi.org/10.1046/j.1365-2133.2003.04936.x.CrossRefPubMed

12.

Andreasen JO. Oral lichen planus. Oral Surgery, Oral Medicine, Oral Pathology. 1968;25:31–42. https://doi.org/10.1016/0030-4220(68)90194-1.CrossRefPubMed

13.

Cheng Y-SL, Gould A, Kurago Z, Fantasia J, Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:332–54. https://doi.org/10.1016/j.oooo.2016.05.004.CrossRefPubMed

14.

Lodi G, Manfredi M, Mercadante V, Murphy R, Carrozzo M. Interventions for treating oral lichen planus: corticosteroid therapies. Cochrane Database Syst Rev. 2020;2:CD001168. https://doi.org/10.1002/14651858.CD001168.pub3.CrossRefPubMed

15.

Liu L-J, Xiao W, He Q-B, Jiang W-W. Generic and oral quality of life is affected by oral mucosal diseases. BMC Oral Health. 2012;12:2. https://doi.org/10.1186/1472-6831-12-2.CrossRefPubMedPubMedCentral

16.

Cervino G, Terranova A, Briguglio F, de Stefano R, Famà F, D’Amico C, et al. Diabetes: oral health related quality of life and oral alterations. Biomed Res Int. 2019;2019:5907195. https://doi.org/10.1155/2019/5907195.CrossRefPubMedPubMedCentral

17.

Cortelli SC, Costa FO, Gargioni-Filho A, Aquino DR, Cota LOM, Scherma AP, et al. Impact of gingivitis treatment for diabetic patients on quality of life related to periodontal objective parameters: a randomized controlled clinical trial. Arch Oral Biol. 2018;86:80–6. https://doi.org/10.1016/j.archoralbio.2017.11.010.CrossRefPubMed

18.

John MT, Miglioretti DL, LeResche L, Koepsell TD, Hujoel P, Micheelis W. German short forms of the Oral Health Impact Profile. Community Dent Oral Epidemiol. 2006;34:277–88. https://doi.org/10.1111/j.1600-0528.2006.00279.x.CrossRefPubMed

19.

Bijur PE, Silver W, Gallagher EJ. Reliability of the visual analog scale for measurement of acute pain. Acad Emerg Med. 2001;8:1153–7. https://doi.org/10.1111/j.1553-2712.2001.tb01132.x.CrossRefPubMed

20.

Ji J, Sundquist J, Sundquist K. Gender-specific incidence of autoimmune diseases from national registers. J Autoimmun. 2016;69:102–6. https://doi.org/10.1016/j.jaut.2016.03.003.CrossRefPubMed

21.

Issa Y, Duxbury AJ, Macfarlane TV, Brunton PA. Oral lichenoid lesions related to dental restorative materials. Br Dent J. 2005;198:361–6. https://doi.org/10.1038/sj.bdj.4812176.CrossRefPubMed

22.

Jirau-Colón H, González-Parrilla L, Martinez-Jiménez J, Adam W, Jiménez-Velez B. Rethinking the dental amalgam dilemma: an integrated toxicological approach. Int J Environ Res Public Health. 2019. https://doi.org/10.3390/ijerph16061036.CrossRefPubMedPubMedCentral

23.

Skoglund A. Value of epicutaneous patch testing in patients with oral, mucosal lesions of lichenoid character. Scand J Dent Res. 1994;102:216–22. https://doi.org/10.1111/j.1600-0722.1994.tb01183.x.CrossRefPubMed

24.

Martin MD, Broughton S, Drangsholt M. Oral lichen planus and dental materials: a case-control study. Contact Derm. 2003;48:331–6. https://doi.org/10.1034/j.1600-0536.2003.00146.x.CrossRef

25.

Ahlgren C, Bruze M, Möller H, Gruvberger B, Axéll T, Liedholm R, Nilner K. Contact allergy to gold in patients with oral lichen lesions. Acta Derm Venereol. 2012;92:138–43. https://doi.org/10.2340/00015555-1247.CrossRefPubMed

26.

Parlatescu I, Tovaru M, Nicolae CL, Sfeatcu R, Didilescu AC. Oral health-related quality of life in different clinical forms of oral lichen planus. Clin Oral Investig. 2020;24:301–8. https://doi.org/10.1007/s00784-019-02951-8.CrossRefPubMed

27.

Karbach J, Al-Nawas B, Moergel M, Daubländer M. Oral health-related quality of life of patients with oral lichen planus, oral leukoplakia, or oral squamous cell carcinoma. J Oral Maxillofac Surg. 2014;72:1517–22. https://doi.org/10.1016/j.joms.2014.04.008.CrossRefPubMed

28.

Aksoy B, Hapa FA. Do we really not need to treat patients with white reticular lesions of oral lichen planus?: A case-control pilot study. TURKDERM. 2018;52:24–8. https://doi.org/10.4274/turkderm.37790.CrossRef

29.

Zuo W, Li X, Chen Y, Peng H. Oral health-related quality of life in patients with oral lichen planus. Hua Xi Kou Qiang Yi Xue Za Zhi. 2012;30:40–4.PubMed

30.

Ni Riordain R, Hodgson T, Porter S, Fedele S. Validity and reliability of the Chronic Oral Mucosal Diseases Questionnaire in a UK population. J Oral Pathol Med. 2016;45:613–6. https://doi.org/10.1111/jop.12425.CrossRefPubMed

31.

McGrath C, Bedi R. A review of the influences of oral health on the quality of life. Int J Health Promot Educ. 1999;37:116–9. https://doi.org/10.1080/14635240.1999.10806111.CrossRef

32.

Daume L, Kreis C, Bohner L, Kleinheinz J, Jung S. Does the Clinical Form of Oral Lichen Planus (OLP) Influence the Oral Health-Related Quality of Life (OHRQoL)? Int J Environ Res Public Health. 2020. https://doi.org/10.3390/ijerph17186633.CrossRefPubMedPubMedCentral

33.

Wiriyakijja P, Porter S, Fedele S, Hodgson T, McMillan R, Shephard M, Ni RR. Validation of the HADS and PSS-10 and psychological status in patients with oral lichen planus. Oral Dis. 2020;26:96–110. https://doi.org/10.1111/odi.13220.CrossRefPubMed

34.

Gavic L, Cigic L, Biocina Lukenda D, Gruden V, Gruden Pokupec JS. The role of anxiety, depression, and psychological stress on the clinical status of recurrent aphthous stomatitis and oral lichen planus. J Oral Pathol Med. 2014;43:410–7. https://doi.org/10.1111/jop.12148.CrossRefPubMed

35.

Zucoloto ML, Shibakura MEW, Pavanin JV, Garcia FT, da Silva Santos PS, Maciel AP, et al. Severity of oral lichen planus and oral lichenoid lesions is associated with anxiety. Clin Oral Investig. 2019;23:4441–8. https://doi.org/10.1007/s00784-019-02892-2.CrossRefPubMed

36.

Pippi R, Romeo U, Santoro M, Del Vecchio A, Scully C, Petti S. Psychological disorders and oral lichen planus: matched case-control study and literature review. Oral Dis. 2016;22:226–34. https://doi.org/10.1111/odi.12423.CrossRefPubMed

37.

Chen HX, Blasiak R, Kim E, Padilla R, Culton DA. Triggers of oral lichen planus flares and the potential role of trigger avoidance in disease management. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124:248–52. https://doi.org/10.1016/j.oooo.2017.05.508.CrossRefPubMed

38.

Fiorillo L. Oral health: the first step to well-being. Medicina (Kaunas). 2019. https://doi.org/10.3390/medicina55100676.CrossRef

39.

Cicciù M, Cervino G, Fiorillo L, D’Amico C, Oteri G, Troiano G, et al. Early diagnosis on oral and potentially oral malignant lesions: a systematic review on the VELscope® fluorescence method. Dent J (Basel). 2019. https://doi.org/10.3390/dj7030093.CrossRef

Title: Clinical characteristics of oral lichen planus and its causal context with dental restorative materials and oral health-related quality of life
Authors: Linda Daume
Constance Kreis
Lauren Bohner
Susanne Jung
Johannes Kleinheinz
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Lichen Planus
Published in: BMC Oral Health / Issue 1/2021
Electronic ISSN: 1472-6831
DOI: https://doi.org/10.1186/s12903-021-01622-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical characteristics of oral lichen planus and its causal context with dental restorative materials and oral health-related quality of life

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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