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Open Access 01-12-2023 | Oral Cancer | Review

Current advances in noninvasive methods for the diagnosis of oral squamous cell carcinoma: a review

Authors: Shan Wang, Mao Yang, Ruiying Li, Jie Bai

Published in: European Journal of Medical Research | Issue 1/2023

Abstract

Oral squamous cell carcinoma (OSCC), one of the most common types of cancers worldwide, is diagnosed mainly through tissue biopsy. However, owing to the tumor heterogeneity and other drawbacks, such as the invasiveness of the biopsy procedure and high cost and limited usefulness of longitudinal surveillance, there has been a focus on adopting more rapid, economical, and noninvasive screening methods. Examples of these include liquid biopsy, optical detection systems, oral brush cytology, microfluidic detection, and artificial intelligence auxiliary diagnosis, which have their own strengths and weaknesses. Extensive research is being performed on various liquid biopsy biomarkers, including novel microbiome components, noncoding RNAs, extracellular vesicles, and circulating tumor DNA. The majority of these elements have demonstrated encouraging clinical outcomes in early OSCC detection. This review summarizes the screening methods for OSCC with a focus on providing new guiding strategies for the diagnosis of the disease.

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Title: Current advances in noninvasive methods for the diagnosis of oral squamous cell carcinoma: a review
Authors: Shan Wang
Mao Yang
Ruiying Li
Jie Bai
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Oral Cancer
Oral Cavity Carcinoma
Biomarkers
Published in: European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-022-00916-4

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Springer Medicine

Current advances in noninvasive methods for the diagnosis of oral squamous cell carcinoma: a review

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Keynote webinar | Spotlight on medication adherence

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