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Journal of Cardiovascular Translational Research

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01-10-2020 | Original Article

Optimal Blood Pressure Control Improves Left Ventricular Torsional Deformation and Vascular Function in Newly Diagnosed Hypertensives: a 3-Year Follow-up Study

Authors: Stavros Tzortzis, Ignatios Ikonomidis, Hellen Triantafyllidi, Paraskevi Trivilou, George Pavlidis, Spyridon Katsanos, Konstantinos Katogiannis, Dionisia Birba, John Thymis, Georgios Makavos, Maria Varoudi, Alexandra Frogoudaki, Agathi-Rosa Vrettou, Dimitrios Vlastos, John Parissis, John Lekakis

Published in: Journal of Cardiovascular Translational Research | Issue 5/2020

Abstract

We investigated the effects of optimizing blood pressure control on cardiac deformation and vascular function. For this purpose, in 200 untreated patients with essential hypertension, we assessed at baseline as well as after 3 years of optimal blood pressure control: arterial stiffness and coronary microcirculatory function as well as longitudinal and torsional deformation parameters. Compared to baseline, after 3 years of optimal blood pressure control, there was an improvement of longitudinal strain, twisting as well as untwisting parameters of the left ventricle. In parallel, there was an improvement in coronary microcirculatory function, arterial stiffness, left ventricular mass, and ventricular-arterial interaction. The reduction of arterial stiffness was independently associated with the respective improvement of cardiac deformation markers and coronary flow reserve after adjusting for blood pressure improvement. Blood pressure optimization improves LV longitudinal and torsional mechanics in hypertensives in parallel with arterial stiffness, resulting in improved ventricular-arterial interaction and coronary flow reserve. Trial registration: ClinicalTrials.gov Identifier: NCT02346695

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Title: Optimal Blood Pressure Control Improves Left Ventricular Torsional Deformation and Vascular Function in Newly Diagnosed Hypertensives: a 3-Year Follow-up Study
Authors: Stavros Tzortzis
Ignatios Ikonomidis
Hellen Triantafyllidi
Paraskevi Trivilou
George Pavlidis
Spyridon Katsanos
Konstantinos Katogiannis
Dionisia Birba
John Thymis
Georgios Makavos
Maria Varoudi
Alexandra Frogoudaki
Agathi-Rosa Vrettou
Dimitrios Vlastos
John Parissis
John Lekakis
Publication date: 01-10-2020
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 5/2020
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-019-09951-9

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Optimal Blood Pressure Control Improves Left Ventricular Torsional Deformation and Vascular Function in Newly Diagnosed Hypertensives: a 3-Year Follow-up Study

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