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American Journal of Clinical Dermatology
Published in: American Journal of Clinical Dermatology 4/2020

01-08-2020 | Omalizumab | Leading Article

New and Emerging Biologics for Atopic Dermatitis

Authors: Wenelia Baghoomian, ChanHo Na, Eric L. Simpson

Published in: American Journal of Clinical Dermatology | Issue 4/2020

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Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by complex pathophysiology involving both skin barrier dysfunction and aberrant type 2 inflammation/immune responses. AD can be a debilitating condition that drastically impairs quality of life, especially in patients with moderate-to-severe disease. Currently, topical therapies such as corticosteroids and non-steroidal immunomodulatory therapy provide limited efficacy for patients with moderate-to-severe AD; limitations include inadequate response, cutaneous toxicity from overuse, and poor tolerance due to stinging and burning. Historically, the development of targeted therapies has been challenging due to the complex and multifaceted etiology of AD. Recent progress in understanding the immunopathology of AD reinforces the development of newly targeted therapeutics. The successful launch of dupilumab, a monoclonal antibody targeting the interleukin (IL)-4α receptor subunit, for AD in 2017 spurred the development of a number of biologics targeting novel cytokine and receptor targets that are now in phase II and III of development. This review aims to explore the rationale behind these novel biological therapies and to summarize current clinical studies of these agents.
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Metadata
Title
New and Emerging Biologics for Atopic Dermatitis
Authors
Wenelia Baghoomian
ChanHo Na
Eric L. Simpson
Publication date
01-08-2020
Publisher
Springer International Publishing
Published in
American Journal of Clinical Dermatology / Issue 4/2020
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI
https://doi.org/10.1007/s40257-020-00515-1

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