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European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 8/2018

01-08-2018 | Rhinology

Olfactory bulbus volume and olfactory sulcus depth in migraine patients: an MRI evaluation

Authors: Adil Doğan, Nuray Bayar Muluk, Mehmet Hamdi Şahan, Neşe Asal, Mikail Inal, Ufuk Ergün

Published in: European Archives of Oto-Rhino-Laryngology | Issue 8/2018

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Abstract

Objectives

To compare the measurements of olfactory bulb volume and olfactory sulcus depth in patients with migraine and a control group.

Methods

The study included the cranial MRI (1.5 T) images of 200 adults diagnosed with migraine and a control group of 100 subjects without migraine. The control group mainly consisted of the patients with non-migraneous headache. The measurements were obtained from coronal T2-weighted images for standard olfactory bulb (OB) volume and olfactory sulcus (OS) depth.

Results

The OB volume and OS depth values were lower in the migraine group than in the control group. In the migraine group, left OB volume of the males was significantly lower than those of the females. In both the migraine and control groups separately, the left-side OB volume values and the right side OS depth values were significantly greater than those of the contralateral side. There were positive correlations between right and left OB volume, and right and left OS depth values. No change was seen in OB volume and OS depth values according to gender. In older patients, a decrease was determined in the right and left OB volume, and the left-side OS depth values. There was a negative correlation between osmophobia and OB volume values. In migraine patients with osmophobia, the OB volume values were significantly decreased.

Conclusion

OB volume values were lower in migraine patients. When osmophobia was present, the OB volume was lower than that of the non-osmophobia migraine patients. Olfactory function monitoring with olfactory tests and olfactory volume monitoring on MRI can be recommended for all migraine patients to diagnose olfactory dysfunction earlier, especially those with osmophobia. Because their OB volume values were detected as lower than those of the migraine patients without osmophobia, it may be thought that blood flow changes and osmophobia may affect the olfactory bulb volume shrinkage in migraine patients.
Literature
1.
Ertas M, Baykan B, Orhan EK, Zarifoglu M, Karli N, Saip S et al (2012) One-year prevalence and the impact of migraine and tension-type headache in Turkey: a nationwide home-based study in adults. J Headache Pain 13:147–157CrossRefPubMedPubMedCentral
2.
Jurgens TP, Schulte LH, May A (2014) Migraine trait symptoms in migraine with and without aura. Neurology 82:1416–1424CrossRefPubMed
3.
4.
5.
Harriott AM, Schwedt TJ (2014) Migraine is associated with altered processing of sensory stimuli. Curr Pain Headache Rep 18:458CrossRefPubMed
6.
Leonardi M, Raggi A (2013) Burden of migraine: international perspectives. Neurol Sci 34(Suppl. 1):S117–S118
7.
Fornazieri MA, Neto AR, de Rezende Pinna F, Gobbi Porto FH, de Lima Navarro P, Voegels RL et al (2016) Olfactory symptoms reported by migraineurs with and without auras. Headache 56(10):1608–1616CrossRefPubMed
8.
9.
Saisu A, Tatsumoto M, Hoshiyama E, Aiba S, Hirata K (2011) Evaluation of olfaction in patients with migraine using an odour stick identification test. Cephalalgia 31(9):1023–1028CrossRefPubMed
10.
Zanchin G, Dainese F, Trucco M, Mainardi F, Mampreso E, Maggioni F (2007) Osmophobia in migraine and tension-type headache and its clinical features in patients with migraine. Cephalalgia 27:1061–1068CrossRefPubMed
11.
Sjostrand C, Savic I, Laudon-Meyer E, Hillert L, Lodin K, Waldenlind E (2010) Migraine and olfactory stimuli. Curr Pain Headache Rep 14:244–51CrossRefPubMed
12.
Lima AM, Sapienza GB, Giraud VO, Fragoso YD (2011) Odors as triggering and worsening factors for migraine in men. Arq Neuropsiquiatr 69:324–327CrossRefPubMed
13.
Kelman L (2004) The place of osmophobia and taste abnormalities in migraine classification: a tertiary care study of 1237 patients. Cephalalgia 24:940–946CrossRefPubMed
14.
.Rombaux P, Duprez T, Hummel T (2009) Olfactory bulb volume in the clinical assessment of olfactory dysfunction. Rhinology 47(1):3–9PubMed
15.
Headache Classification Committee of the International Headache Society (IHS) (2013) The international classification of headache disorders, 3rd edn (beta version) Cephalalgia 33(9):629–808CrossRef
16.
Thierry P, Duprez A, Rombaux P (2010) Imaging the olfactory tract. Eur J Radiol 74:288–298CrossRef
17.
Buschhüter D, Smitka M, Puschmann S, Gerber JC, Witt M, Abolmaali ND et al (2008) Correlation between olfactory bulb volume and olfactory function. Neuroimage 42:498–502CrossRefPubMed
18.
Rombaux P, Wetz H, Mouraux A, Nicolas G, Bertrand B, Duprez T et al (2006) Olfactory function assessed with orthonasal and retronasal testing, olfactory bulb volume and chemosensory event related potentials. Arch Otolaryngol Head Neck Surg 132:1346–1351CrossRefPubMed
19.
Kobal G, Klimek L, Wolfensberger M, Gudziol H, Temmel A, Owen CM et al. (2000) Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination and olfactory thresholds. Eur Arch Otorhinolaryngol 257: 205–11CrossRef
20.
Heilmann S, Strehle G, Rosenheim K, Damm M, Hummel T (2002) Clinical assessment of retronasal olfactory function. Arch Otolaryngol Head Neck Surg 128:414–418CrossRefPubMed
21.
Frasnelli J, Landis BN, Heilmann S, Hauswald B, Hüttenbrink KB, Lacroix JS et al (2004) Clinical presentation of qualitative olfactory dysfunction. Eur Arch Otorhinolaryngol 261:411–415CrossRefPubMed
22.
Youssem DM, Geckle RJ, Doty RL (1995) Evaluation of olfactory deficits in neurodegenerative disorders. In: The Radiological Society of North America Scientific Program. Chicago, IL, USA, Abstract 271
23.
Mueller A, Abolmaali ND, Hakini AR, Gloeckler T, Herting B, Reichmann H et al (2005) Olfactory bulb volume in patients with idiopathic Parkinson’s disease—a pilot study. J Neural Transm 112:1363–1370CrossRefPubMed
24.
Hudspeth AJ (2000) Hearing. In: Kandel ER, Schwartz JH, Jessell TM (eds) Principles of neural science, 4th edn. The McGrawHill Companies, NewYork, pp 481–498
25.
Rombaux P, Mouraux A, Bertrand B, Nicolas G, Duprez T, Hummel T (2006) Olfactory function and olfactory bulb volume in patients with postinfectious olfactory loss. Laryngoscope 116:436–439CrossRefPubMed
26.
Kayabaşoglu G, Altundag A, Kotan D, Dizdar D, Kaymaz R (2017) Osmophobia and olfactory functions in patients with migraine. Eur Arch Otorhinolaryngol 274(2):817–21CrossRefPubMed
27.
Demarquay G, Royet JP, Mick G, Ryvlin P (2008) Olfactory hypersensitivity in migraineurs: A H(2)(15)O-PET study. Cephalalgia 28:1069–1080CrossRefPubMed
Metadata
Title
Olfactory bulbus volume and olfactory sulcus depth in migraine patients: an MRI evaluation
Authors
Adil Doğan
Nuray Bayar Muluk
Mehmet Hamdi Şahan
Neşe Asal
Mikail Inal
Ufuk Ergün
Publication date
01-08-2018
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 8/2018
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-018-5029-x

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