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European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 2/2017

01-02-2017 | Rhinology

Osmophobia and olfactory functions in patients with migraine

Authors: Gürkan Kayabaşoglu, Aytug Altundag, Dilcan Kotan, Denizhan Dizdar, Recep Kaymaz

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2017

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Abstract

Olfactory dysfunction and migraine has been associated for a long time. In this study, we planned to compare olfactory functions in patients with migraine and osmophobia with patients having migraine but no osmophobia, in addition with a normal control group using “Sniffin’ Sticks” test. The main distinction of this study is that all qualitative and quantitative properties of olfactory functions; threshold, discrimination and identification, are evaluated separately and jointly. Thirty healthy person aged between 16 and 56 (18 women, 12 men) and 60 migraine patients aged between 15 and 54 (39 women, 21 man) were included in the study. All patients have been inquired about osmophobia and have been assessed with Hedonic tone assessment. Osmophobia has been tested for perfume, cigarette smoke, leather, stale food, soy sauce, fish, spices and coffee smells. Olfactory functions has been assessed with “Sniffin’ Sticks” smell test. Thresholds, discrimination and identification have been determined for each patient. In migraine patients with osmophobia, threshold was 7.75 ± 2.3, in migraine patients without osmophobia threshold was 8.25 ± 1.5 and threshold was 10.75 ± 1.3 for the control group. Discrimination score was 6 ± 1.2 in migraine patients with osmophobia, 9 ± 0.8 in patients without osmophobia and was 12 ± 1.4 in the control group. In migraine patient with or without osmophobia Threshold/Discrimination/Identification (TDI) scores were lower than the control group. The most important parameter in our study is that discrimination scores were especially lower in patients with osmophobia. We believe that this decrease in discrimination in migraine patients with osmophobia; who claim that they smell everything and they are sensitive to all smells, is significant. Further studies about smell discrimination will help better understand some conditions; especially anosmia and hyposmia after upper respiratory tract infections and parosmia.
Literature
1.
Ertas M, Baykan B, Orhan EK, Zarifoglu M, Karli N, Saip S, Onal AE, Siva A (2012) One-year prevalence and the impact of migraine and tension-type headache in Turkey: a nationwide home-based study in adults. J Headache Pain 13:147–157CrossRefPubMedPubMedCentral
2.
Headache Classification Subcommittee of the International Headache Society (2004) The international classification of headache disorders: 2nd ed. Cephalalgia 24(Suppl 1):9–160
3.
Demarquay G, Royet JP, Giraud P, Chazot G, Valade D, Ryvlin P (2006) Rating of olfactory judgements in migraine patients. Cephalalgia 26(9):1123–1130CrossRefPubMed
4.
5.
Sjöstrand C, Savic I, Laudon-Meyer E, Hillert L, Lodin K, Waldenlind E (2010) Migraine and olfactory stimuli. Curr Pain Headache Rep 14(3):244–251CrossRefPubMed
6.
Stankewitz A, May A (2011) Increased limbic and brainstem activity during migraine attacks following olfactory stimulation. Neurology 77(5):476–482CrossRefPubMed
7.
Coleman ER, Grosberg BM, Robbins MS (2011) Olfactory hallucinations in primary headache disorders: case series and literature review. Cephalalgia 31(14):1477–1489CrossRefPubMed
8.
Saisu A, Tatsumoto M, Hoshiyama E, Aiba S, Hirata K (2011) Evaluation of olfaction in patients with migraine using an odour stick identification test. Cephalalgia 31(9):1023–1028CrossRefPubMed
9.
10.
11.
Hudspeth AJ (2000) Hearing. In: Kandel ER, Schwartz JH, Jessell TM (eds) Principles of neural science, 4th edn. The McGraw-Hill Companies, New York, pp 481–498
12.
Olsson P, Berglind N, Bellander T, Stjärne P (2000) Prevalence of self-reported allergic and non-allergic rhinitis symptoms in Stockholm: relation to age, gender, olfactory sense, and smoking. Acta Otolaryngol 123:75–80CrossRef
13.
Murphy C, Schubert CR, Cruickshanks KJ, Klein BE, Klein R, Nondahl DM (2002) Prevalence of olfactory impairment in older adults. JAMA 288:2307–2312CrossRefPubMed
14.
Landis BN, Hummel T (2006) New evidence for high occurrence of olfactory dysfunctions within the population. Am J Med 119(1):91–92CrossRefPubMed
15.
Nordin S, Brämerson A, Millqvist E, Bende M (2001) Prevalence of parosmia: the Skövde population-based studies. Rhinology 45(1):50–53
16.
Nordin S, Bramerson A, Bende M (2004) Prevalence of self-reported poor odor detection sensitivity: the Skovde population-based study. Acta Otolaryngol 124:1171–1173CrossRefPubMed
17.
Altundag A, Tekeli H, Salihoglu M, Cayonu M, Kendirli MT, Yasar H, Ozturk A (2014) A study on olfactory dysfunction in Turkish population with using survey method and validated olfactory testing. Indian J Otolaryngol Head Neck Surg. doi:10.​1007/​s12070-014-0720-8 PubMedPubMedCentral
18.
Temmel AF, Quint C, Schickinger-Fischer B, Klimek L, Stoller E, Hummel T (2002) Characteristics of olfactory disorders in relation to major causes of olfactory loss. Arch Otolaryngol Head Neck Surg 128:635–641CrossRefPubMed
19.
Attems J, Walker L, Jellinger KA (2014) Olfactory bulb involvement in neurodegenerative diseases. Acta Neuropathol 127(4):459–475CrossRefPubMed
20.
Huisman E, Uylings HB, Hoogland PV (2004) A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson’s disease. Mov Disord 19:687–692CrossRefPubMed
21.
Attems J, Lintner F, Jellinger KA (2005) Olfactory involvement in aging and Alzheimer’s disease: an autopsy study. J Alzheimers Dis 7:149–157PubMed
22.
Attems J, Jellinger KA (2006) Olfactory tau pathology in Alzheimer disease and mild cognitive impairment. Clin Neuropathol 25:265–271PubMed
23.
Doty RL (2012) Olfaction in Parkinson’s disease and related disorders. Neurobiol Dis 46(3):527–552CrossRefPubMed
24.
Guyton AC, Hall JE (eds) (2006) The special senses. In: Textbook of medical physiology. Elsevier, New York, p 613
25.
Tekeli H, Altundağ A, Salihoğlu M, Çayönü M, Kendirli MT (2013) The applicability of the “Sniffin’ Sticks” olfactory test in a Turkish population. Med Sci Monit 19:1221–1226CrossRefPubMedPubMedCentral
26.
Croy I, Symmank A, Schellong J, Hummel C, Gerber J, Joraschky P, Hummel T (2014) Olfaction as a marker for depression in humans. J Affect Disord 160:80–86CrossRefPubMed
27.
Cameron EL (2007) Measures of human olfactory perception during pregnancy. Chem Senses 32(8):775–782CrossRefPubMed
28.
Nordin S, Broman DA, Olofsson JK, Wulff M (2004) A longitudinal descriptive study of self-reported abnormal smell and taste perception in pregnant women. Chem Senses 29(5):391–402CrossRefPubMed
29.
Ochsenbein-Kölble N, von Mering R, Zimmermann R, Hummel T (2007) Changes in olfactory function in pregnancy and postpartum. Int J Gynaecol Obstet 97(1):10–14CrossRefPubMed
30.
De Carlo D, Toldo I, Dal Zotto L, Perissinotto E, Sartori S, Gatta M, Balottin U, Mazzotta G, Moscato D, Raieli V, Rossi LN, Sangermani R, Soriani S, Termine C, Tozzi E, Vecchio A, Zanchin G, Battistella PA (2012) Osmophobia as an early marker of migraine: a follow-up study in juvenile patients. Cephalalgia 32(5):401–406CrossRefPubMed
31.
32.
Altundag A, Tekeli H, Salihoglu M, Cayonu M, Yasar H, Kendirli MT, Saglam O (2015) Cross-culturally modified University of Pennsylvania Smell Identification Test for a Turkish population. Am J Rhinol Allergy 29(5):e138–e141CrossRefPubMed
Metadata
Title
Osmophobia and olfactory functions in patients with migraine
Authors
Gürkan Kayabaşoglu
Aytug Altundag
Dilcan Kotan
Denizhan Dizdar
Recep Kaymaz
Publication date
01-02-2017
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Oto-Rhino-Laryngology / Issue 2/2017
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-016-4283-z

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