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Cardiovascular Drugs and Therapy
Published in: Cardiovascular Drugs and Therapy 2/2018

01-04-2018 | REVIEW ARTICLE

Old Drugs for New Indications in Cardiovascular Medicine

Authors: Yaron Arbel, Wael Abuzeid, Robert S Rosenson, Alanna Weisman, Michael E. Farkouh

Published in: Cardiovascular Drugs and Therapy | Issue 2/2018

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Abstract

Inflammation participates in the initiation and progression of atherosclerotic cardiovascular disease, and it is a critical inciting factor leading to acute ischemic events. Evidence has shown that certain anti-inflammatory medications used to treat non-atherosclerotic inflammatory diseases reduce cardiovascular events. This article reviews evidence that commonly used anti-inflammatory therapies (colchicine, allopurinol, methotrexate), reduce cardiovascular events. We discuss potential mechanisms of action, efficacy, and safety of these therapies and propose a clinical trials design to investigate their efficacy.
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Metadata
Title
Old Drugs for New Indications in Cardiovascular Medicine
Authors
Yaron Arbel
Wael Abuzeid
Robert S Rosenson
Alanna Weisman
Michael E. Farkouh
Publication date
01-04-2018
Publisher
Springer US
Published in
Cardiovascular Drugs and Therapy / Issue 2/2018
Print ISSN: 0920-3206
Electronic ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-018-6785-y

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