Published in:
Open Access
01-12-2021 | Obesity | Letter to the Editor
Vitamin D association with coagulation factors in polycystic ovary syndrome is dependent upon body mass index
Authors:
Abu Saleh Md Moin, Thozhukat Sathyapalan, Alexandra E. Butler, Stephen L. Atkin
Published in:
Journal of Translational Medicine
|
Issue 1/2021
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Excerpt
Polycystic ovary syndrome (PCOS) is associated with metabolic consequences including obesity and insulin resistance that are related to the excess prevalence of type 2 diabetes, hypertension, and cardiovascular diseases in later life [
1]. It is reported that PCOS subjects show marked platelet dysfunction [
2] and decreased plasma fibrinolytic activity, resulting in a prothrombotic state [
3]. In addition, coagulation variables such as thrombin-activatable fibrinolysis inhibitor, plasminogen activator inhibitor-1 (PAI-1), D-dimer, Antithrombin and thrombomodulin have been reported to be elevated in PCOS compared to control subjects [
4], and the functional coagulation tests including prothrombin time, thrombin time and fibrin degradation products may be predictive of PCOS [
5]. This suggests that PCOS women have a propensity to a hypercoagulable state; therefore, to determine whether this was the case in a cohort of PCOS women, and whether there was an association with vitamin D status, this study was undertaken. …