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14-10-2022 | Obesity | Research Letter to the editor

Reporting and representation of obesity in randomized controlled trials of noninvasive oxygenation strategies in hypoxemic respiratory failure

Authors: Timothy G. Gaulton, Lorenzo Berra, Bruno L. Ferreyro, Maurizio Cereda

Published in: Internal and Emergency Medicine | Issue 8/2022

Excerpt

Hypoxemic respiratory failure is a common cause of critical illness and is associated with high rates of mortality [1]. Obesity is a major risk factor for developing hypoxemic respiratory failure, an association that has been highly visible within the coronavirus pandemic, where nearly half of patients needing intensive care have had obesity [2‐4]. …

Scala R, Heunks L (2018) Highlights in acute respiratory failure. Eur Respir Rev. https://doi.org/10.1183/16000617.0008-2018CrossRefPubMed

Hibbert K, Rice M, Malhotra A (2012) Obesity and ARDS. Chest 1423:785–790. https://doi.org/10.1378/chest.12-0117CrossRef

Cummings MJ, Baldwin MR, Abrams D, Jacobson SD, Meyer BJ, Balough EM, Aaron JG, Claassen J, Rabbani LE, Hastie J et al (2020) Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study. Lancet 39510239:1763–1770. https://doi.org/10.1016/S0140-6736(20)31189-2CrossRef

Kompaniyets L, Goodman AB, Belay B, Freedman DS, Sucosky MS, Lange SJ, Gundlapalli AV, Boehmer TK, Blanck HM (2021) Body Mass Index and Risk for COVID-19-Related Hospitalization, Intensive Care Unit Admission, Invasive Mechanical Ventilation, and Death - United States, March-December 2020. MMWR Morb Mortal Wkly Rep 7010:355–361. https://doi.org/10.15585/mmwr.mm7010e4CrossRef

Gray A, Goodacre S, Newby DE, Masson M, Sampson F, Nicholl J, Trialists CPO (2008) Noninvasive ventilation in acute cardiogenic pulmonary edema. N Engl J Med 3592:142–151. https://doi.org/10.1056/NEJMoa0707992CrossRef

De Jong A, Wrigge H, Hedenstierna G, Gattinoni L, Chiumello D, Frat JP, Ball L, Schetz M, Pickkers P, Jaber S (2020) How to ventilate obese patients in the ICU. Intensive Care Med 4612:2423–2435. https://doi.org/10.1007/s00134-020-06286-xCrossRef

Fumagalli J, Santiago RRS, Teggia Droghi M, Zhang C, Fintelmann FJ, Troschel FM, Morais CCA, Amato MBP, Kacmarek RM, Berra L et al (2019) Lung recruitment in obese patients with acute respiratory distress syndrome. Anesthesiology 1305:791–803. https://doi.org/10.1097/ALN.0000000000002638CrossRef

Neligan PJ, Malhotra G, Fraser M, Williams N, Greenblatt EP, Cereda M, Ochroch EA (2009) Continuous positive airway pressure via the Boussignac system immediately after extubation improves lung function in morbidly obese patients with obstructive sleep apnea undergoing laparoscopic bariatric surgery. Anesthesiology 1104:878–884. https://doi.org/10.1097/ALN.0b013e31819b5d8cCrossRef

Ferreyro BL, Angriman F, Munshi L, Del Sorbo L, Ferguson ND, Rochwerg B, Ryu MJ, Saskin R, Wunsch H, da Costa BR et al (2020) Association of noninvasive oxygenation strategies with all-cause mortality in adults with acute hypoxemic respiratory failure: a systematic review and meta-analysis. JAMA 3241:57–67. https://doi.org/10.1001/jama.2020.9524CrossRef

10.

Pestine E, Stokes A, Trinquart L (2018) Representation of obese participants in obesity-related cancer randomized trials. Ann Oncol 297:1582–1587. https://doi.org/10.1093/annonc/mdy138CrossRef

11.

Sabin JA, Marini M, Nosek BA (2012) Implicit and explicit anti-fat bias among a large sample of medical doctors by BMI, race/ethnicity and gender. PLoS ONE 711:e48448. https://doi.org/10.1371/journal.pone.0048448CrossRef

12.

Courtright K (2016) POINT: do randomized controlled trials ignore needed patient populations? Yes. Chest 1495:1128–1130. https://doi.org/10.1016/j.chest.2016.01.029CrossRef

Title: Reporting and representation of obesity in randomized controlled trials of noninvasive oxygenation strategies in hypoxemic respiratory failure
Authors: Timothy G. Gaulton
Lorenzo Berra
Bruno L. Ferreyro
Maurizio Cereda
Publication date: 14-10-2022
Publisher: Springer International Publishing
Keywords: Obesity
Obesity
Published in: Internal and Emergency Medicine / Issue 8/2022
Print ISSN: 1828-0447
Electronic ISSN: 1970-9366
DOI: https://doi.org/10.1007/s11739-022-03118-2

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