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BMC Public Health
Published in: BMC Public Health 1/2024

Open Access 01-12-2024 | Obesity | Research

Prevalence, associated factors, and gene polymorphisms of obesity in Tibetan adults in Qinghai, China

Authors: Ye Wang, Li Pan, Huijing He, Zhanquan Li, Sen Cui, Airong Yang, Wenfang Li, Guoqiang Jia, Ximing Han, Xianghua Wang, Guangliang Shan

Published in: BMC Public Health | Issue 1/2024

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Abstract

Objectives

To explore the prevalence and associated factors of obesity in Tibetan adults in Qinghai, China, and to determine the association between the FTO (rs1121980 and rs17817449) and MC4R gene (rs17782313 and rs12970134) polymorphisms with obesity.

Methods

A cross-sectional survey was conducted in 2015 in Qinghai to selected Tibetan adults aged 20 to 80 years. Prevalence of obesity (BMI ≥ 28 kg/m2) and overweight (BMI 24 ~ 27.9 kg/m2) were evaluated. Multivariable logistic models were used to determine the associated factors. Pair-matched subjects of obesity cases and normal-weight controls were selected for the gene polymorphism analyses. Conditional logistic models were used to assess the association between gene polymorphisms with obesity. Additive and multiplicative gene-environment interactions were tested.

Results

A total of 1741 Tibetan adults were enrolled. The age- and sex- standardized prevalence of obesity and overweight was 18.09% and 31.71%, respectively. Male sex, older age, heavy level of leisure-time exercise, current smoke, and heavy level of occupational physical activity were associated with both obesity and overweight. MC4R gene polymorphisms were associated with obesity in Tibetan adults. No significant gene-environment interaction was detected.

Conclusion

The prevalence of obesity and overweight in Tibetan adults was high. Both environmental and genetic factors contributed to the obesity prevalent.
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Metadata
Title
Prevalence, associated factors, and gene polymorphisms of obesity in Tibetan adults in Qinghai, China
Authors
Ye Wang
Li Pan
Huijing He
Zhanquan Li
Sen Cui
Airong Yang
Wenfang Li
Guoqiang Jia
Ximing Han
Xianghua Wang
Guangliang Shan
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2024
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-023-17181-7

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