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Archives of Gynecology and Obstetrics

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01-11-2019 | Obesity | Maternal-Fetal Medicine

Offspring of women following bariatric surgery and those of patients with obesity are at an increased risk for long-term pediatric endocrine morbidity

Authors: Pinhas Damti, Michael Friger, Daniella Landau, Ruslan Sergienko, Eyal Sheiner

Published in: Archives of Gynecology and Obstetrics | Issue 5/2019

Abstract

Objective

To assess whether offspring of women following bariatric surgery as well as offspring of obese women are at an increased risk for long-term pediatric endocrine morbidity.

Setting

This study was conducted at the university hospital.

Methods

A population-based cohort study compared the incidence of long-term (up to the age of 18 years) occurrence of endocrine morbidity between offspring of mothers following bariatric surgery and obese mothers, as compared with parturients without obesity and without prior bariatric surgery.

Results

During the study period 220,563 newborns met the inclusion criteria; 1001 were delivered by patients following bariatric surgery, 2275 were delivered by obese women and 217,287 were delivered by normal weight women without prior bariatric surgery. Long-term endocrine morbidity was more common in the bariatric group (2.3%) and the obesity group (1.5%) as compared with the comparison group (0.5%; P < 0.001). Specifically, pediatric obesity was significantly more common in children of mothers following bariatric surgery (1.8%) and of mothers with obesity (1.2%) as compared with the comparison group (0.2%; P < 0.001). Children born to women following bariatric surgery as well as obese women had higher cumulative incidence of pediatric endocrine morbidity (Log rank, P < 0.001). The results remained significant when controlling for maternal factors, adjusted HR 6.25, 95% CI 4.10–9.50; P < 0.001 for women following bariatric surgery and aHR 2.40 95% CI 1.69–3.40; P < 0.001 for obese women.

Conclusion

Offspring of women following bariatric surgery as well as those of obese women are at an increased risk for long-term pediatric endocrine morbidity.

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Title: Offspring of women following bariatric surgery and those of patients with obesity are at an increased risk for long-term pediatric endocrine morbidity
Authors: Pinhas Damti
Michael Friger
Daniella Landau
Ruslan Sergienko
Eyal Sheiner
Publication date: 01-11-2019
Publisher: Springer Berlin Heidelberg
Keywords: Obesity
Obesity
Bariatric Surgery
Bariatric Surgery
Published in: Archives of Gynecology and Obstetrics / Issue 5/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05322-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Offspring of women following bariatric surgery and those of patients with obesity are at an increased risk for long-term pediatric endocrine morbidity

Abstract

Objective

Setting

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Setting

Methods

Results

Conclusion

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