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Archives of Gynecology and Obstetrics

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01-11-2019 | Misoprostol | General Gynecology

The role of repeat misoprostol dose in the management of early pregnancy failure

Authors: Amihai Rottenstreich, Gabriel Levin, Avi Ben Shushan, Simcha Yagel, Shay Porat

Published in: Archives of Gynecology and Obstetrics | Issue 5/2019

Abstract

Purpose

We aimed to assess the role of repeat misoprostol administration in those with thickened endometrium in the management of early pregnancy failure (EPF).

Methods

A retrospective cohort study in two university hospitals among women receiving misoprostol treatment for EPF. Those with thickened endometrium at the first follow-up visit, who received a repeat 800 µg dose of vaginal misoprostol in institution B and no treatment in institution A, constituted the study group. The primary outcome was treatment success, defined as complete uterine evacuation without the need for any operative intervention

Results

Overall, 608 women with thickened endometrium as assessed by transvaginal ultrasonography 2 days following initial misoprostol administration for EPF were included. Of them, 427 did not receive repeat misoprostol dose, and 181 received repeat misoprostol dose. The rate of surgical intervention did not differ between those who received a repeat misoprostol dose (6.1%) and those who did not (4.3%) (P = 0.32). The median endometrial thickness was similar in those that did and did not require subsequent surgical intervention (P = 0.65), and was a poor predictor of treatment outcome.

Conclusions

Repeat misoprostol administration among women with thickened endometrium following initial misoprostol administration for EPF was not associated with improved treatment success rates.

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Title: The role of repeat misoprostol dose in the management of early pregnancy failure
Authors: Amihai Rottenstreich
Gabriel Levin
Avi Ben Shushan
Simcha Yagel
Shay Porat
Publication date: 01-11-2019
Publisher: Springer Berlin Heidelberg
Keyword: Misoprostol
Published in: Archives of Gynecology and Obstetrics / Issue 5/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05274-x

At a glance: The STEP trials

Springer Medicine

The role of repeat misoprostol dose in the management of early pregnancy failure

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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