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Archives of Gynecology and Obstetrics

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01-03-2020 | Obesity | Gynecologic Endocrinology and Reproductive Medicine

Maternal exposure to a high-fat diet showed unfavorable effects on the body weight, apoptosis and morphology of cardiac myocytes in offspring

Authors: Xiao-Min Ma, Qing-Yun Shi, Yong-Xian Zhao

Published in: Archives of Gynecology and Obstetrics | Issue 3/2020

Abstract

Objective

The study intends to explore the functions of maternal high-fat diet exposure on progeny weight and heart.

Methods

Sprague–Dawley (SD) rats, fed on a high-fat diet, were used to establish a model of weight gain before and during pregnancy. The body and cardiac weight of neonatal, 1-month- and 3-month-old rats were measured. The morphology of myocardial cells was observed by hemotoxylin and eosin (H&E) staining. The expression of caspase-3, 8, 9 was measured by qRT-PCR and western blot.

Results

Normal pregnant rats, fed on a high-fat diet throughout pregnancy, had a significant increase in body and cardiac weight of their neonates, and more fat deposition in myocardial cells and an increased expression of caspase-3, 8, 9, compared with that of the normal pregnant rats + normal diet group. These phenomena were relieved through later diet control. Pregnant rats, which fed on a high-fat diet throughout pregnancy, showed more adverse effects on neonatal body and cardiac weight, myocardial cell fat deposition, and the expression of caspase-3, 8, 9, compared with pregnant rats exposed to high-fat diet + normal diet and pregnant rats exposed to high-fat diet + normal diet + exercise. These phenomena cannot be fully restored via controlling later diet.

Conclusions

Our results stated that a proper diet before and during pregnancy was important for the cardiac health of offspring.

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Title: Maternal exposure to a high-fat diet showed unfavorable effects on the body weight, apoptosis and morphology of cardiac myocytes in offspring
Authors: Xiao-Min Ma
Qing-Yun Shi
Yong-Xian Zhao
Publication date: 01-03-2020
Publisher: Springer Berlin Heidelberg
Keywords: Obesity
Obesity
Published in: Archives of Gynecology and Obstetrics / Issue 3/2020
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-020-05470-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Maternal exposure to a high-fat diet showed unfavorable effects on the body weight, apoptosis and morphology of cardiac myocytes in offspring

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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