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Endocrine

Published in:

28-09-2023 | Obesity | Review

Immune cells in adipose tissue microenvironment under physiological and obese conditions

Authors: Yuchen Jiang, Fengying Gong

Published in: Endocrine | Issue 1/2024

Abstract

Purpose

This review will focus on the immune cells in adipose tissue microenvironment and their regulatory roles in metabolic homeostasis of adipose tissue and even the whole body under physiological and obese conditions.

Methods

This review used PubMed searches of current literature to examine adipose tissue immune cells and cytokines, as well as the complex interactions between them.

Results

Aside from serving as a passive energy depot, adipose tissue has shown specific immunological function. Adipose tissue microenvironment is enriched with a large number of immune cells and cytokines, whose physiological regulation plays a crucial role for metabolic homeostasis. However, obesity causes pro-inflammatory alterations in these adipose tissue immune cells, which have detrimental effects on metabolism and increase the susceptibility of individuals to the obesity related diseases.

Conclusions

Adipose tissue microenvironment is enriched with various immune cells and cytokines, which regulate metabolic homeostasis of adipose tissue and even the whole body, whether under physiological or obese conditions. Targeting key immune cells and cytokines in adipose tissue microenvironment for obesity treatment becomes an attractive research point.

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Title: Immune cells in adipose tissue microenvironment under physiological and obese conditions
Authors: Yuchen Jiang
Fengying Gong
Publication date: 28-09-2023
Publisher: Springer US
Keywords: Obesity
Obesity
Insulins
Insulins
Cytokines
Published in: Endocrine / Issue 1/2024
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-023-03521-5

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