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Trials
Published in: Trials 1/2022

Open Access 01-12-2022 | Obesity | Study protocol

Effects of physical training on physical and functional fitness, physical activity level, endothelial function, hemodynamic variables, bone metabolism, and quality of life of post-bariatric patients: study protocol for a randomized controlled trial

Authors: Karynne Grutter Lopes, Maria das Graças Coelho de Souza, Michelle da Costa Tavares Bezerra, Lucas Miranda Bessa, Paulo Farinatti, Eliete Bouskela, Miguel Madeira, Luiz Guilherme Kraemer-Aguiar

Published in: Trials | Issue 1/2022

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Abstract

Background

Evidence of the benefits induced from resistance exercise on health markers of post-bariatric patients is limited. The study will investigate the effects of a resistance training (RT) program on muscle mass and strength, bone metabolism biomarkers, bone mineral density (BMD), bone microarchitecture, and endothelial function of patients subjected to Roux-en-Y gastric bypass.

Methods/design

This randomized controlled trial will include 60 post-bariatric patients, physically inactive, aging 18 to 50 years, with a post-surgery period ≥ 12 months. They will be randomly assigned into two groups: (i) the non-exercised control group, which will receive the standard clinical follow-up, or (ii) the intervention group which will consist of RT (60 min/session; 3 times/week, for 6 months). The primary outcomes will include muscle mass and strength, bone metabolism biomarkers, BMD, and bone microarchitecture. The secondary outcomes will be anthropometry, hemodynamic measurements, cardiovascular risk factors, health-related quality of life (QoL), and endothelial function. Outcomes will be assessed by blood biomarkers of bone formation and reabsorption, dual X-ray absorptiometry, repetition maximum and handgrip strength tests, high-resolution peripheral quantitative computed tomography, 36-Item Short-Form Health Survey, venous occlusion plethysmography, and nailfold videocapillaroscopy.

Discussion

It is expected that there are greater benefits from the RT program, possibly improving muscle mass and strength, bone metabolism, density and microarchitecture, QoL, and cardiovascular risk.

Trial registration

ClinicalTrials.gov NCT04193397. Registered on 7 December 2019.
Appendix
Available only for authorised users
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Metadata
Title
Effects of physical training on physical and functional fitness, physical activity level, endothelial function, hemodynamic variables, bone metabolism, and quality of life of post-bariatric patients: study protocol for a randomized controlled trial
Authors
Karynne Grutter Lopes
Maria das Graças Coelho de Souza
Michelle da Costa Tavares Bezerra
Lucas Miranda Bessa
Paulo Farinatti
Eliete Bouskela
Miguel Madeira
Luiz Guilherme Kraemer-Aguiar
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Trials / Issue 1/2022
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-022-06677-z

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