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Osteoporosis International

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01-10-2020 | Obesity | Original Article

Association between benign paroxysmal positional vertigo and osteoporosis: two nested case-control studies

Authors: S. Y. Kim, H.-J. Kim, C. Min, H. G. Choi

Published in: Osteoporosis International | Issue 10/2020

Abstract

Summary

Benign paroxysmal positional vertigo (BPPV) was related to a 1.28 times higher risk of osteoporosis. In addition, osteoporosis was associated with a 1.34 times higher risk of BPPV. This bidirectional relation was maintained after adjusting past medical histories and lifestyle factors, including obesity, smoking, and alcohol consumption. To our knowledge, this is the first study to explore the reciprocal association between BPPV and osteoporosis. In subgroup analyses, only women showed a reciprocal association between BPPV and osteoporosis.

Introduction

A previous population cohort study suggested an association between osteoporosis and benign paroxysmal positional vertigo (BPPV). This study aimed to investigate the bidirectional association between BPPV and osteoporosis.

Methods

The Korean National Health Insurance Service-Health Screening Cohort data from 2002 to 2013 were used. In study I, the 50,897 osteoporosis patients were 1:1 matched with control I participants for age, sex, income, and region of residence. The previous histories of BPPV were analyzed in both groups using conditional logistic regression analysis. In study II, 9621 BPPV patients were 1:4 matched with control II participants. The previous histories of osteoporosis were analyzed in both groups using conditional logistic regression analysis. According to age and sex, subgroup analyses were achieved in both studies I and II.

Results

A total of 1.6% (822/50,897) of osteoporosis patients and 1.3% (644/50,897) of control I participants had BPPV. The osteoporosis patients demonstrated a 1.28 times higher chance of developing BPPV (95% confidence intervals [95% CI] = 1.16–1.42, P < 0.001). In study II, 21.2% (2040/9621) of BPPV patients and 17.6% (6790/38,484) of control II participants had osteoporosis. The BPPV patients showed 1.34 times higher chance of having osteoporosis (95% CI = 1.26–1.43, P < 0.001). In the analysis of the women subgroup, these relations were reliable.

Conclusion

Osteoporosis patients had increased odds of having BPPV. On the other hand, BPPV patients had increased odds of having osteoporosis. This bidirectional relation was consistent only in the women subgroup.

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Title: Association between benign paroxysmal positional vertigo and osteoporosis: two nested case-control studies
Authors: S. Y. Kim
H.-J. Kim
C. Min
H. G. Choi
Publication date: 01-10-2020
Publisher: Springer London
Keywords: Obesity
Obesity
Benign Paroxysmal Positional Vertigo
Osteoporosis
Osteoporosis
Published in: Osteoporosis International / Issue 10/2020
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-020-05478-x

2024 ASCO Annual Meeting

Springer Medicine

Association between benign paroxysmal positional vertigo and osteoporosis: two nested case-control studies

Abstract

Summary

Introduction

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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