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Published in: The journal of nutrition, health & aging 5/2021

Open Access 01-05-2021 | Nutrition

Nutritional Interventions for Early Dementia

Authors: Matteo Cesari, D. Azzolino, B. Arosio, M. Canevelli

Published in: The journal of nutrition, health & aging | Issue 5/2021

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Abstract

Nutrition plays a critical role in the definition of the individual’s wellbeing. Nutritional interventions have been repeatedly advocated as of potential interest for preventing or delaying the cognitive decline, also in the context of neurodegenerative conditions. The idea of targeting the initial phases of dementia, when the process is theoretically still amenable of correction, via lifestyle modifications (including healthy diet or supplementation of specific micro-/macro-nutrients) is extremely appealing. In this perspective paper, we describe the most recent evidence on the topic and discuss how the nutritional assessment should be nested within a comprehensive approach to the aging person with initial signs of dementia for promoting his/her optimal management.
Literature
1.
go back to reference Volkert D, Chourdakis M, Faxen-Irving G et al. ESPEN guidelines on nutrition in dementia. Clin Nutr 2015; 34: 1052–1073.CrossRef Volkert D, Chourdakis M, Faxen-Irving G et al. ESPEN guidelines on nutrition in dementia. Clin Nutr 2015; 34: 1052–1073.CrossRef
2.
go back to reference Calvani R, Miccheli A, Landi F et al. Current nutritional recommendations and novel dietary strategies to manage sarcopenia. J Frailty Aging 2013; 2: 16. Calvani R, Miccheli A, Landi F et al. Current nutritional recommendations and novel dietary strategies to manage sarcopenia. J Frailty Aging 2013; 2: 16.
3.
go back to reference Jung S, Hermann J, Bishop A. Impact of nutritional risk on self-care capacity: social support as a source of protection for community-dwelling older adults living in a rural area. J Frailty Aging 2013; 2: 145–149.PubMed Jung S, Hermann J, Bishop A. Impact of nutritional risk on self-care capacity: social support as a source of protection for community-dwelling older adults living in a rural area. J Frailty Aging 2013; 2: 145–149.PubMed
4.
go back to reference Landi F, Sieber C, Fielding RA, Rolland Y, Guralnik J, The ICFSR Task Force. Nutritional Intervention in Sarcopenia: Report from the International Conference on Frailty and Sarcopenia Research Task Force. J Frailty Aging 2018; 7: 247–252.PubMed Landi F, Sieber C, Fielding RA, Rolland Y, Guralnik J, The ICFSR Task Force. Nutritional Intervention in Sarcopenia: Report from the International Conference on Frailty and Sarcopenia Research Task Force. J Frailty Aging 2018; 7: 247–252.PubMed
5.
go back to reference Burgener SC, Buettner L, Buckwalter KC et al. Evidence supporting nutritional interventions for persons in early stage Alzheimer’s disease (AD). J Nutr Health Aging 2008; 12: 18–21.CrossRef Burgener SC, Buettner L, Buckwalter KC et al. Evidence supporting nutritional interventions for persons in early stage Alzheimer’s disease (AD). J Nutr Health Aging 2008; 12: 18–21.CrossRef
6.
go back to reference Gillette Guyonnet S, Abellan Van Kan G, Andrieu S et al. IANA task force on nutrition and cognitive decline with aging. J Nutr Health Aging 2007; 11: 132–152.PubMed Gillette Guyonnet S, Abellan Van Kan G, Andrieu S et al. IANA task force on nutrition and cognitive decline with aging. J Nutr Health Aging 2007; 11: 132–152.PubMed
7.
go back to reference The Orlando Frailty Conference Group. Raising awareness on the urgent need to implement frailty into clinical practice. J Frailty Aging 2013; 2: 121–124.PubMedCentral The Orlando Frailty Conference Group. Raising awareness on the urgent need to implement frailty into clinical practice. J Frailty Aging 2013; 2: 121–124.PubMedCentral
8.
go back to reference Kelaiditi E, Cesari M, Canevelli M et al. Cognitive frailty: rational and definition from an IANA-IAGG international consensus group. J Nutr Health Aging 2013; 17: 726–734.CrossRef Kelaiditi E, Cesari M, Canevelli M et al. Cognitive frailty: rational and definition from an IANA-IAGG international consensus group. J Nutr Health Aging 2013; 17: 726–734.CrossRef
9.
go back to reference Doorduijn AS, de van der Schueren MAE, van de Rest O et al. Olfactory and gustatory functioning and food preferences of patients with Alzheimer’s disease and mild cognitive impairment compared to controls: the NUDAD project. J Neurol 2020; 267: 144–152.CrossRef Doorduijn AS, de van der Schueren MAE, van de Rest O et al. Olfactory and gustatory functioning and food preferences of patients with Alzheimer’s disease and mild cognitive impairment compared to controls: the NUDAD project. J Neurol 2020; 267: 144–152.CrossRef
10.
go back to reference Olde Rikkert MGM, Verhey FR, Sijben JWC et al. Differences in Nutritional Status Between Very Mild Alzheimer’s Disease Patients and Healthy Controls. J Alzheimers Dis 2014; 41: 261–271.CrossRef Olde Rikkert MGM, Verhey FR, Sijben JWC et al. Differences in Nutritional Status Between Very Mild Alzheimer’s Disease Patients and Healthy Controls. J Alzheimers Dis 2014; 41: 261–271.CrossRef
11.
go back to reference Doorduijn AS, van de Rest O, van der Flier WM, Visser M, de van der Schueren MAE. Energy and Protein Intake of Alzheimer’s Disease Patients Compared to Cognitively Normal Controls: Systematic Review. Journal of the American Medical Directors Association 2019; 20: 14–21.CrossRef Doorduijn AS, van de Rest O, van der Flier WM, Visser M, de van der Schueren MAE. Energy and Protein Intake of Alzheimer’s Disease Patients Compared to Cognitively Normal Controls: Systematic Review. Journal of the American Medical Directors Association 2019; 20: 14–21.CrossRef
12.
go back to reference Wang R, Yan Z, Liang Y et al. Prevalence and Patterns of Chronic Disease Pairs and Multimorbidity among Older Chinese Adults Living in a Rural Area. PLoS One 2015; 10: e0138521.CrossRef Wang R, Yan Z, Liang Y et al. Prevalence and Patterns of Chronic Disease Pairs and Multimorbidity among Older Chinese Adults Living in a Rural Area. PLoS One 2015; 10: e0138521.CrossRef
13.
go back to reference Abad-Díez J, Calderón-Larrañaga A, Poncel-Falcó A et al. Age and gender differences in the prevalence and patterns of multimorbidity in the older population. BMC Geriatr 2014; 14: 75.CrossRef Abad-Díez J, Calderón-Larrañaga A, Poncel-Falcó A et al. Age and gender differences in the prevalence and patterns of multimorbidity in the older population. BMC Geriatr 2014; 14: 75.CrossRef
14.
go back to reference Bauer J, Biolo G, Cederholm T et al. Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group. J Am Med Dir Assoc 2013; 14: 542–559.CrossRef Bauer J, Biolo G, Cederholm T et al. Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group. J Am Med Dir Assoc 2013; 14: 542–559.CrossRef
15.
go back to reference Deutz N, Bauer J, Barazzoni R et al. Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group. Clin Nutr 2014; 33: 929–936.CrossRef Deutz N, Bauer J, Barazzoni R et al. Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group. Clin Nutr 2014; 33: 929–936.CrossRef
16.
go back to reference de Kerimel J, Tavassoli N, Lafont C et al. How to Manage Frail Older Adults in the Community? Proposal of a Health Promotion Program Experienced in a City of 16,638 Inhabitants in France. J Frailty Aging 2018; 7: 120–126.PubMed de Kerimel J, Tavassoli N, Lafont C et al. How to Manage Frail Older Adults in the Community? Proposal of a Health Promotion Program Experienced in a City of 16,638 Inhabitants in France. J Frailty Aging 2018; 7: 120–126.PubMed
17.
go back to reference Jesus P, Desport J, Massoulard A et al. Nutritional assessment and follow-up of residents with and without dementia in nursing homes in the limousin region of France: a health network initiative. J Nutr Health Aging 2012; 16: 504–508.CrossRef Jesus P, Desport J, Massoulard A et al. Nutritional assessment and follow-up of residents with and without dementia in nursing homes in the limousin region of France: a health network initiative. J Nutr Health Aging 2012; 16: 504–508.CrossRef
18.
go back to reference Cesari M, Incalzi R, Zamboni V, Pahor M. Vitamin D hormone: A multitude of actions potentially influencing the physical function decline in older persons. Geriatr Gerontol Int 2011; 11: 133–142.CrossRef Cesari M, Incalzi R, Zamboni V, Pahor M. Vitamin D hormone: A multitude of actions potentially influencing the physical function decline in older persons. Geriatr Gerontol Int 2011; 11: 133–142.CrossRef
19.
go back to reference Basile M, Ciardi L, Crespi I, Saliva E, Bellomo G, Vidali M. Assessing serum concentrations of 25-hydroxy-vitamin D in North-Western Italy. J Frailty Aging 2013; 2: 174–178.PubMed Basile M, Ciardi L, Crespi I, Saliva E, Bellomo G, Vidali M. Assessing serum concentrations of 25-hydroxy-vitamin D in North-Western Italy. J Frailty Aging 2013; 2: 174–178.PubMed
20.
go back to reference Hamilton B. Vitamin D and Human Skeletal Muscle. Scandinavian Journal of Medicine & Science in Sports 2009 Hamilton B. Vitamin D and Human Skeletal Muscle. Scandinavian Journal of Medicine & Science in Sports 2009
21.
go back to reference Hooshmand B, Lokk J, Solomon A et al. Vitamin D in Relation to Cognitive Impairment, Cerebrospinal Fluid Biomarkers, and Brain Volumes. J Gerontol A Biol Sci Med Sci 2014; 69: 1132–1138.CrossRef Hooshmand B, Lokk J, Solomon A et al. Vitamin D in Relation to Cognitive Impairment, Cerebrospinal Fluid Biomarkers, and Brain Volumes. J Gerontol A Biol Sci Med Sci 2014; 69: 1132–1138.CrossRef
22.
go back to reference Volkert D, Saeglitz C, Gueldenzoph H, Sieber C, Stehle P. Undiagnosed malnutrition and nutrition-related problems in geriatric patients. J Nutr Health Aging 2010; 14: 387–392.CrossRef Volkert D, Saeglitz C, Gueldenzoph H, Sieber C, Stehle P. Undiagnosed malnutrition and nutrition-related problems in geriatric patients. J Nutr Health Aging 2010; 14: 387–392.CrossRef
23.
go back to reference Kaiser M, Bauer J, Rämsch C et al. Frequency of malnutrition in older adults: a multinational perspective using the mini nutritional assessment. J Am Geriatr Soc 2010; 58: 1734–1738.CrossRef Kaiser M, Bauer J, Rämsch C et al. Frequency of malnutrition in older adults: a multinational perspective using the mini nutritional assessment. J Am Geriatr Soc 2010; 58: 1734–1738.CrossRef
24.
go back to reference Ponjoan A, Garre-Olmo J, Blanch J et al. Epidemiology of dementia: prevalence and incidence estimates using validated electronic health records from primary care. Clin Epidemiol 2019; 11: 217–228.CrossRef Ponjoan A, Garre-Olmo J, Blanch J et al. Epidemiology of dementia: prevalence and incidence estimates using validated electronic health records from primary care. Clin Epidemiol 2019; 11: 217–228.CrossRef
25.
go back to reference Vandewoude MFJ, van Wijngaarden JP, De Maesschalck L, Luiking YC, Van Gossum A. The prevalence and health burden of malnutrition in Belgian older people in the community or residing in nursing homes: results of the NutriAction II study. Aging Clin Exp Res 2019; 31: 175–183.CrossRef Vandewoude MFJ, van Wijngaarden JP, De Maesschalck L, Luiking YC, Van Gossum A. The prevalence and health burden of malnutrition in Belgian older people in the community or residing in nursing homes: results of the NutriAction II study. Aging Clin Exp Res 2019; 31: 175–183.CrossRef
26.
go back to reference Guigoz Y. Frailty and nutrition: what we have learned from research and clinical practice on the Mini Nutritional Assessment. J Frailty Aging 2012; 1: 52–55.PubMed Guigoz Y. Frailty and nutrition: what we have learned from research and clinical practice on the Mini Nutritional Assessment. J Frailty Aging 2012; 1: 52–55.PubMed
27.
go back to reference Nieuwenhuizen W, Weenen H, Rigby P, Hetherington M. Older adults and patients in need of nutritional support: review of current treatment options and factors influencing nutritional intake. Clin Nutr (Edinburgh, Scotland) 2010; 29: 160–169.CrossRef Nieuwenhuizen W, Weenen H, Rigby P, Hetherington M. Older adults and patients in need of nutritional support: review of current treatment options and factors influencing nutritional intake. Clin Nutr (Edinburgh, Scotland) 2010; 29: 160–169.CrossRef
28.
go back to reference Jadczak AD, Visvanathan R. Anorexia of Aging — An Updated Short Review. J Nutr Health Aging 2019; 23: 306–309.CrossRef Jadczak AD, Visvanathan R. Anorexia of Aging — An Updated Short Review. J Nutr Health Aging 2019; 23: 306–309.CrossRef
29.
go back to reference Cox NJ, Morrison L, Ibrahim K, Robinson SM, Sayer AA, Roberts HC. New horizons in appetite and the anorexia of ageing. Age Ageing 2020; 49: 526–534.CrossRef Cox NJ, Morrison L, Ibrahim K, Robinson SM, Sayer AA, Roberts HC. New horizons in appetite and the anorexia of ageing. Age Ageing 2020; 49: 526–534.CrossRef
30.
go back to reference Probert N, Lööw A, Akner G, Wretenberg P, Andersson ÅG. A Comparison of Patients with Hip Fracture, Ten Years Apart: Morbidity, Malnutrition and Sarcopenia. J Nutr Health Aging 2020; 24: 870–877.CrossRef Probert N, Lööw A, Akner G, Wretenberg P, Andersson ÅG. A Comparison of Patients with Hip Fracture, Ten Years Apart: Morbidity, Malnutrition and Sarcopenia. J Nutr Health Aging 2020; 24: 870–877.CrossRef
31.
go back to reference Correia M, Hegazi R, Higashiguchi T et al. Evidence-based recommendations for addressing malnutrition in health care: an updated strategy from the feedM.E. Global Study Group. J Am Med Dir Assoc 2014; 15: 544–550.CrossRef Correia M, Hegazi R, Higashiguchi T et al. Evidence-based recommendations for addressing malnutrition in health care: an updated strategy from the feedM.E. Global Study Group. J Am Med Dir Assoc 2014; 15: 544–550.CrossRef
32.
go back to reference Thomas D, Ashmen W, Morley J, Evans W. Nutritional management in long-term care: development of a clinical guideline. Council for Nutritional Strategies in Long-Term Care. J Gerontol A Biol Sci Med Sci 2000; 55: M725–34.CrossRef Thomas D, Ashmen W, Morley J, Evans W. Nutritional management in long-term care: development of a clinical guideline. Council for Nutritional Strategies in Long-Term Care. J Gerontol A Biol Sci Med Sci 2000; 55: M725–34.CrossRef
33.
go back to reference Nutrition and dementia: A review of available research. London, United Kingdom: Alzheimer’s Disease International, 2014. Nutrition and dementia: A review of available research. London, United Kingdom: Alzheimer’s Disease International, 2014.
34.
go back to reference World report on ageing and health. Geneva, Switzerland: World Health Organization, 2015. World report on ageing and health. Geneva, Switzerland: World Health Organization, 2015.
35.
go back to reference Soysal P, Dokuzlar O, Erken N, Dost Günay FS, Isik AT. The Relationship Between Dementia Subtypes and Nutritional Parameters in Older Adults. J Am Med Dir Assoc 2020 Soysal P, Dokuzlar O, Erken N, Dost Günay FS, Isik AT. The Relationship Between Dementia Subtypes and Nutritional Parameters in Older Adults. J Am Med Dir Assoc 2020
36.
go back to reference Edington J, Barnes R, Bryan F et al. A prospective randomised controlled trial of nutritional supplementation in malnourished elderly in the community: clinical and health economic outcomes. Clin Nutr 2004; 23: 195–204.CrossRef Edington J, Barnes R, Bryan F et al. A prospective randomised controlled trial of nutritional supplementation in malnourished elderly in the community: clinical and health economic outcomes. Clin Nutr 2004; 23: 195–204.CrossRef
37.
go back to reference Meijers J, Candel M, Schols J, van Bokhorst-de van der Schueren M, Halfens R. Decreasing trends in malnutrition prevalence rates explained by regular audits and feedback. J Nutr 2009; 139: 1381–1386.CrossRef Meijers J, Candel M, Schols J, van Bokhorst-de van der Schueren M, Halfens R. Decreasing trends in malnutrition prevalence rates explained by regular audits and feedback. J Nutr 2009; 139: 1381–1386.CrossRef
38.
go back to reference Integrated care for older people (ICOPE): Guidance for person-centred assessment and pathways in primary care. World Health Organization, 2019. Integrated care for older people (ICOPE): Guidance for person-centred assessment and pathways in primary care. World Health Organization, 2019.
39.
go back to reference Marzetti E, Sanna T, Calvani R, Bernabei R, Landi F, Cesari M. Brand New Medicine for an Older Society. J Am Med Dir Assoc 2016; 17: 558–559.CrossRef Marzetti E, Sanna T, Calvani R, Bernabei R, Landi F, Cesari M. Brand New Medicine for an Older Society. J Am Med Dir Assoc 2016; 17: 558–559.CrossRef
40.
go back to reference Rolfson DB, Heckman GA, Bagshaw SM, Robertson D, Hirdes JP, Canadian Frailty Network. Implementing Frailty Measures in the Canadian Healthcare System. J Frailty Aging 2018; 7: 208–216.PubMed Rolfson DB, Heckman GA, Bagshaw SM, Robertson D, Hirdes JP, Canadian Frailty Network. Implementing Frailty Measures in the Canadian Healthcare System. J Frailty Aging 2018; 7: 208–216.PubMed
41.
go back to reference Sanchez-Rodriguez D, Annweiler C, Gillain S, Vellas B. Implementation of the Integrated Care of Older People (ICOPE) App in Primary Care: New Technologies in Geriatric Care During Quarantine of COVID-19 and Beyond. J Frailty Aging 2020 Sanchez-Rodriguez D, Annweiler C, Gillain S, Vellas B. Implementation of the Integrated Care of Older People (ICOPE) App in Primary Care: New Technologies in Geriatric Care During Quarantine of COVID-19 and Beyond. J Frailty Aging 2020
42.
go back to reference Cummings J, Passmore P, McGuinness B et al. Souvenaid in the management of mild cognitive impairment: an expert consensus opinion. Alz Res Therapy 2019; 11: 73.CrossRef Cummings J, Passmore P, McGuinness B et al. Souvenaid in the management of mild cognitive impairment: an expert consensus opinion. Alz Res Therapy 2019; 11: 73.CrossRef
43.
go back to reference Scheltens P, Twisk JWR, Blesa R et al. Efficacy of Souvenaid in Mild Alzheimer’s Disease: Results from a Randomized, Controlled Trial. J Alzheimers Dis 2012; 31: 225–236.CrossRef Scheltens P, Twisk JWR, Blesa R et al. Efficacy of Souvenaid in Mild Alzheimer’s Disease: Results from a Randomized, Controlled Trial. J Alzheimers Dis 2012; 31: 225–236.CrossRef
44.
go back to reference Scheltens P, Kamphuis PJGH, Verhey FRJ et al. Efficacy of a medical food in mild Alzheimer’s disease: A randomized, controlled trial. Alzheimers Dement 2010; 6: 1–10.e1.CrossRef Scheltens P, Kamphuis PJGH, Verhey FRJ et al. Efficacy of a medical food in mild Alzheimer’s disease: A randomized, controlled trial. Alzheimers Dement 2010; 6: 1–10.e1.CrossRef
45.
go back to reference Soininen H, Solomon A, Visser PJ et al. 24-month intervention with a specific multinutrient in people with prodromal Alzheimer’s disease (LipiDiDiet): a randomised, double-blind, controlled trial. Lancet Neurol 2017; 16: 965–975.CrossRef Soininen H, Solomon A, Visser PJ et al. 24-month intervention with a specific multinutrient in people with prodromal Alzheimer’s disease (LipiDiDiet): a randomised, double-blind, controlled trial. Lancet Neurol 2017; 16: 965–975.CrossRef
Metadata
Title
Nutritional Interventions for Early Dementia
Authors
Matteo Cesari
D. Azzolino
B. Arosio
M. Canevelli
Publication date
01-05-2021
Publisher
Springer Paris
Published in
The journal of nutrition, health & aging / Issue 5/2021
Print ISSN: 1279-7707
Electronic ISSN: 1760-4788
DOI
https://doi.org/10.1007/s12603-021-1616-4

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