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Published in: BMC Public Health 1/2012

Open Access 01-12-2012 | Study protocol

Nutrition and physical activity programs for obesity treatment (PRONAF study): methodological approach of the project

Authors: Augusto G Zapico, Pedro J Benito, Marcela González-Gross, Ana B Peinado, Esther Morencos, Blanca Romero, Miguel A Rojo-Tirado, Rocio Cupeiro, Barbara Szendrei, Javier Butragueño, Maite Bermejo, María Alvarez-Sánchez, Miguel García-Fuentes, Carmen Gómez-Candela, Laura M Bermejo, Ceila Fernandez-Fernandez, Francisco J Calderón

Published in: BMC Public Health | Issue 1/2012

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Abstract

Background

At present, scientific consensus exists on the multifactorial etiopatogenia of obesity. Both professionals and researchers agree that treatment must also have a multifactorial approach, including diet, physical activity, pharmacology and/or surgical treatment. These two last ones should be reserved for those cases of morbid obesities or in case of failure of the previous ones. The aim of the PRONAF study is to determine what type of exercise combined with caloric restriction is the most appropriate to be included in overweigth and obesity intervention programs, and the aim of this paper is to describe the design and the evaluation methods used to carry out the PRONAF study.

Methods/design

One-hundred nineteen overweight (46 males) and 120 obese (61 males) subjects aged 18–50 years were randomly assigned to a strength training group, an endurance training group, a combined strength + endurance training group or a diet and physical activity recommendations group. The intervention period was 22 weeks (in all cases 3 times/wk of training for 22 weeks and 2 weeks for pre and post evaluation). All subjects followed a hypocaloric diet (25-30% less energy intake than the daily energy expenditure estimated by accelerometry). 29–34% of the total energy intake came from fat, 14–20% from protein, and 50–55% from carbohydrates. The mayor outcome variables assesed were, biochemical and inflamatory markers, body composition, energy balance, physical fitness, nutritional habits, genetic profile and quality of life. 180 (75.3%) subjects finished the study, with a dropout rate of 24.7%. Dropout reasons included: personal reasons 17 (28.8%), low adherence to exercise 3 (5.1%), low adherence to diet 6 (10.2%), job change 6 (10.2%), and lost interest 27 (45.8%).

Discussion

Feasibility of the study has been proven, with a low dropout rate which corresponds to the estimated sample size. Transfer of knowledge is foreseen as a spin-off, in order that overweight and obese subjects can benefit from the results. The aim is to transfer it to sports centres. Effectiveness on individual health-related parameter in order to determine the most effective training programme will be analysed in forthcoming publications.

Trial registration

ClinicalTrials.gov NCT01116856
Appendix
Available only for authorised users
Literature
1.
Berghofer A, Pischon T, Reinhold T, Apovian CM, Sharma AM, Willich SN: Obesity prevalence from a European perspective: a systematic review. BMC Publ Health. 2008, 8: 200-10.1186/1471-2458-8-200.CrossRef
2.
Bellido A, Soto JM, García Almeida M, de la López T: Foro ACTUA II (abordaje y recomendaciones de actuación útil sobre el exceso de peso en atención primaria). Revista Española de Obesidad. 2008, 6 (4): 175-197.
3.
Salas-Salvadó J, Rubio MA, Barbany M, Moreno B, Aranceta J, Bellido D, Blay V, Carraro R, Formiguera X, Foz M, et al: Consenso SEEDO 2007 para la evaluación del sobrepeso y la obesidad y el establecimiento de criterios de intervención terapéutica. Rev Esp Obes. 2007, 3: 7-48.
4.
Gutin B: Diet vs exercise for the prevention of pediatric obesity: the role of exercise. Int J Obes (Lond). 2011, 35: 29-32. 10.1038/ijo.2010.140.CrossRef
5.
Maziak W, Ward KD, Stockton MB: Childhood obesity: are we missing the big picture?. Obes Rev. 2008, 9 (1): 35-42. 10.1111/j.1467-789X.2007.00436.x.PubMed
6.
Wing RR, Lang W, Wadden TA, Safford M, Knowler WC, Bertoni AG, Hill JO, Brancati FL, Peters A, Wagenknecht L: Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care. 2011, 34 (7): 1481-1486. 10.2337/dc10-2415.CrossRefPubMedPubMedCentral
7.
Rodríguez A, López-Valcárcel BG: El transfondo económico de las intervenciones sanitarias en la prevención de la obesidad. Rev Esp Salud Publica. 2009, 83: 25-41. 10.1590/S1135-57272009000100003.CrossRef
8.
Hunter GR, Wetzstein CJ, Fields DA, Brown A, Bamman MM: Resistance training increases total energy expenditure and free-living physical activity in older adults. J Appl Physiol. 2000, 89 (3): 977-984.PubMed
9.
Poehlman ET, Dvorak RV, DeNino WF, Brochu M, Ades PA: Effects of resistance training and endurance training on insulin sensitivity in nonobese, young women: a controlled randomized trial. J Clin Endocrinol Metab. 2000, 85 (7): 2463-2468. 10.1210/jc.85.7.2463.PubMed
10.
Ryan AS: Insulin resistance with aging: effects of diet and exercise. Sports Med. 2000, 30 (5): 327-346. 10.2165/00007256-200030050-00002.CrossRefPubMed
11.
Castaneda C, Layne JE, Munoz-Orians L, Gordon PL, Walsmith J, Foldvari M, Roubenoff R, Tucker KL, Nelson ME: A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care. 2002, 25 (12): 2335-2341. 10.2337/diacare.25.12.2335.CrossRefPubMed
12.
Dunstan DW, Daly RM, Owen N, Jolley D, De Courten M, Shaw J, Zimmet P: High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care. 2002, 25 (10): 1729-1736. 10.2337/diacare.25.10.1729.CrossRefPubMed
13.
Fahlman MM, Boardley D, Lambert CP, Flynn MG: Effects of endurance training and resistance training on plasma lipoprotein profiles in elderly women. J Gerontol A Biol Sci Med Sci. 2002, 57 (2): B54-B60. 10.1093/gerona/57.2.B54.CrossRefPubMed
14.
Hunter GR, Bryan DR, Wetzstein CJ, Zuckerman PA, Bamman MM: Resistance training and intra-abdominal adipose tissue in older men and women. Med Sci Sports Exerc. 2002, 34 (6): 1023-1028. 10.1097/00005768-200206000-00019.CrossRefPubMed
15.
Janssen I, Fortier A, Hudson R, Ross R: Effects of an energy-restrictive diet with or without exercise on abdominal fat, intermuscular fat, and metabolic risk factors in obese women. Diabetes Care. 2002, 25 (3): 431-438. 10.2337/diacare.25.3.431.CrossRefPubMed
16.
Maiorana A, O’Driscoll G, Goodman C, Taylor R, Green D: Combined aerobic and resistance exercise improves glycemic control and fitness in type 2 diabetes. Diabetes Res Clin Pract. 2002, 56 (2): 115-123. 10.1016/S0168-8227(01)00368-0.CrossRefPubMed
17.
Poehlman ET, Denino WF, Beckett T, Kinaman KA, Dionne IJ, Dvorak R, Ades PA: Effects of endurance and resistance training on total daily energy expenditure in young women: a controlled randomized trial. J Clin Endocrinol Metab. 2002, 87 (3): 1004-1009. 10.1210/jc.87.3.1004.CrossRefPubMed
18.
Baldi JC, Snowling N: Resistance training improves glycaemic control in obese type 2 diabetic men. Int J Sports Med. 2003, 24 (6): 419-423.CrossRefPubMed
19.
Banz WJ, Maher MA, Thompson WG, Bassett DR, Moore W, Ashraf M, Keefer DJ, Zemel MB: Effects of resistance versus aerobic training on coronary artery disease risk factors. Exp Biol Med (Maywood). 2003, 228 (4): 434-440.
20.
Park SK, Park JH, Kwon YC, Kim HS, Yoon MS, Park HT: The effect of combined aerobic and resistance exercise training on abdominal fat in obese middle-aged women. J Physiol Anthropol Appl Human Sci. 2003, 22 (3): 129-135. 10.2114/jpa.22.129.CrossRefPubMed
21.
Reynolds TH, Supiano MA, Dengel DR: Resistance training enhances insulin-mediated glucose disposal with minimal effect on the tumor necrosis factor-alpha system in older hypertensives. Metabolism. 2004, 53 (3): 397-402. 10.1016/j.metabol.2003.09.017.CrossRefPubMed
22.
Tokmakidis SP, Zois CE, Volaklis KA, Kotsa K, Touvra AM: The effects of a combined strength and aerobic exercise program on glucose control and insulin action in women with type 2 diabetes. Eur J Appl Physiol. 2004, 92 (4–5): 437-442.PubMed
23.
Cauza E, Hanusch-Enserer U, Strasser B, Ludvik B, Metz-Schimmerl S, Pacini G, Wagner O, Georg P, Prager R, Kostner K, et al: The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2 diabetes mellitus. Arch Phys Med Rehabil. 2005, 86 (8): 1527-1533. 10.1016/j.apmr.2005.01.007.CrossRefPubMed
24.
Fatouros IG, Tournis S, Leontsini D, Jamurtas AZ, Sxina M, Thomakos P, Manousaki M, Douroudos I, Taxildaris K, Mitrakou A: Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol Metab. 2005, 90 (11): 5970-5977. 10.1210/jc.2005-0261.CrossRefPubMed
25.
Ibanez J, Izquierdo M, Arguelles I, Forga L, Larrion JL, Garcia-Unciti M, Idoate F, Gorostiaga EM: Twice-weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes. Diabetes Care. 2005, 28 (3): 662-667. 10.2337/diacare.28.3.662.CrossRefPubMed
26.
Kukkonen-Harjula KT, Borg PT, Nenonen AM, Fogelholm MG: Effects of a weight maintenance program with or without exercise on the metabolic syndrome: a randomized trial in obese men. Prev Med. 2005, 41 (3–4): 784-790.CrossRefPubMed
27.
Arciero PJ, Gentile CL, Martin-Pressman R, Ormsbee MJ, Everett M, Zwicky L, Steele CA: Increased dietary protein and combined high intensity aerobic and resistance exercise improves body fat distribution and cardiovascular risk factors. Int J Sport Nutr Exerc Metab. 2006, 16 (4): 373-392.PubMed
28.
Fenkci S, Sarsan A, Rota S, Ardic F: Effects of resistance or aerobic exercises on metabolic parameters in obese women who are not on a diet. Adv Ther. 2006, 23 (3): 404-413. 10.1007/BF02850161.CrossRefPubMed
29.
Ferrara CM, Goldberg AP, Ortmeyer HK, Ryan AS: Effects of aerobic and resistive exercise training on glucose disposal and skeletal muscle metabolism in older men. J Gerontol A Biol Sci Med Sci. 2006, 61 (5): 480-487. 10.1093/gerona/61.5.480.CrossRefPubMed
30.
Shaibi GQ, Cruz ML, Ball GD, Weigensberg MJ, Salem GJ, Crespo NC, Goran MI: Effects of resistance training on insulin sensitivity in overweight latino adolescent males. Med Sci Sports Exerc. 2006, 38 (7): 1208-1215. 10.1249/01.mss.0000227304.88406.0f.CrossRefPubMed
31.
Brooks N, Layne JE, Gordon PL, Roubenoff R, Nelson ME, Castaneda-Sceppa C: Strength training improves muscle quality and insulin sensitivity in hispanic older adults with type 2 diabetes. Int J Med Sci. 2007, 4 (1): 19-27.CrossRef
32.
Olson TP, Dengel DR, Leon AS, Schmitz KH: Changes in inflammatory biomarkers following one-year of moderate resistance training in overweight women. Int J Obes (Lond). 2007, 31 (6): 996-1003. 10.1038/sj.ijo.0803534.CrossRef
33.
Sigal RJ, Kenny GP, Boule NG, Wells GA, Prud’homme D, Fortier M, Reid RD, Tulloch H, Coyle D, Phillips P, et al: Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med. 2007, 147 (6): 357-369.CrossRefPubMed
34.
Camargo MD, Stein R, Ribeiro JP, Schvartzman PR, Rizzatti MO, Schaan BD: Circuit weight training and cardiac morphology: a trial with magnetic resonance imaging. Br J Sports Med. 2008, 42 (2): 141-145. discussion 145CrossRefPubMed
35.
Hunter GR, Byrne NM, Sirikul B, Fernandez JR, Zuckerman PA, Darnell BE, Gower BA: Resistance training conserves fat-free mass and resting energy expenditure following weight loss. Obesity (Silver Spring). 2008, 16 (5): 1045-1051. 10.1038/oby.2008.38.CrossRef
36.
Bouchard DR, Soucy L, Senechal M, Dionne IJ, Brochu M: Impact of resistance training with or without caloric restriction on physical capacity in obese older women. Menopause. 2009, 16 (1): 66-72. 10.1097/gme.0b013e31817dacf7.CrossRefPubMed
37.
Brochu M, Malita MF, Messier V, Doucet E, Strychar I, Lavoie JM, Prud’homme D, Rabasa-Lhoret R: Resistance training does not contribute to improving the metabolic profile after a 6-month weight loss program in overweight and obese postmenopausal women. J Clin Endocrinol Metab. 2009, 94 (9): 3226-3233. 10.1210/jc.2008-2706.CrossRefPubMed
38.
Davidson LE, Hudson R, Kilpatrick K, Kuk JL, McMillan K, Janiszewski PM, Lee S, Lam M, Ross R: Effects of exercise modality on insulin resistance and functional limitation in older adults: a randomized controlled trial. Arch Intern Med. 2009, 169 (2): 122-131. 10.1001/archinternmed.2008.558.CrossRefPubMed
39.
Kirk EP, Donnelly JE, Smith BK, Honas J, Lecheminant JD, Bailey BW, Jacobsen DJ, Washburn RA: Minimal resistance training improves daily energy expenditure and fat oxidation. Med Sci Sports Exerc. 2009, 41 (5): 1122-1129. 10.1249/MSS.0b013e318193c64e.CrossRefPubMedPubMedCentral
40.
Sillanpaa E, Laaksonen DE, Hakkinen A, Karavirta L, Jensen B, Kraemer WJ, Nyman K, Hakkinen K: Body composition, fitness, and metabolic health during strength and endurance training and their combination in middle-aged and older women. Eur J Appl Physiol. 2009, 106 (2): 285-296. 10.1007/s00421-009-1013-x.CrossRefPubMed
41.
Del Corral P, Chandler-Laney PC, Casazza K, Gower BA, Hunter GR: Effect of dietary adherence with or without exercise on weight loss: a mechanistic approach to a global problem. J Clin Endocrinol Metab. 2009, 94 (5): 1602-1607. 10.1210/jc.2008-1057.CrossRefPubMedPubMedCentral
42.
Salas-Salvadó J, Rubio MA, Barbany M, Moreno B, Aranceta J, Bellido D, Blay V, Carraro R, Formiguera X, Foz M, et al: Recomendaciones nuticionales basadas en la evidencia para la prevención y el tratamiento del sobrepeso y la obesidad en adultos. Rev Esp Obes. 2011, 9 (Suplemento): 6-78.
43.
Singhal A, Trilk JL, Jenkins NT, Bigelman KA, Cureton KJ: Effect of intensity of resistance exercise on postprandial lipemia. J Appl Physiol. 2009, 106 (3): 823-829. 10.1152/japplphysiol.90726.2008.CrossRefPubMed
44.
Donnelly JE, Blair SN, Jakicic JM, Manore MM, Rankin JW, Smith BK: American college of sports medicine position stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc. 2009, 41 (2): 459-471. 10.1249/MSS.0b013e3181949333.CrossRefPubMed
45.
Morgan BWS, Tiidus PM: Aerobic energy expenditure during recreational weight training in females and males. J Sports Sci Med. 2003, 2 (1303–2968): 117-122.PubMedPubMedCentral
46.
Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD, McManus K, Champagne CM, Bishop LM, Laranjo N, et al: Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med. 2009, 360 (9): 859-873. 10.1056/NEJMoa0804748.CrossRefPubMedPubMedCentral
47.
Ghroubi S, Elleuch H, Chikh T, Kaffel N, Abid M, Elleuch MH: Physical training combined with dietary measures in the treatment of adult obesity. A comparison of two protocols. Ann Phys Rehabil Med. 2009, 52 (5): 394-413. 10.1016/j.rehab.2008.12.017.CrossRefPubMed
48.
Carter J, Jeukendrup AE: Validity and reliability of three commercially available breath-by-breath respiratory systems. Eur J Appl Physiol. 2002, 86 (5): 435-441. 10.1007/s00421-001-0572-2.CrossRefPubMed
49.
Foss O, Hallen J: Validity and stability of a computerized metabolic system with mixing chamber. Int J Sports Med. 2005, 26 (7): 569-575. 10.1055/s-2004-821317.CrossRefPubMed
50.
51.
Morgan B, Woodruff SJ, Tiidus PM: Aerobic energy expenditure during recreational weight training in females y males. J Sports Sci & Med. 2003, 2: 117-122.
52.
Jurca R, Lamonte MJ, Church TS, Earnest CP, Fitzgerald SJ, Barlow CE, Jordan AN, Kampert JB, Blair SN: Associations of muscle strength and fitness with metabolic syndrome in men. Med Sci Sports Exerc. 2004, 36 (8): 1301-1307. 10.1249/01.MSS.0000135780.88930.A9.CrossRefPubMed
53.
Murphy SL: Review of physical activity measurement using accelerometers in older adults: considerations for research design and conduct. Prev Med. 2009, 48 (2): 108-114. 10.1016/j.ypmed.2008.12.001.CrossRefPubMed
54.
Brooks R: EuroQol: the current state of play. Health Policy. 1996, 37 (1): 53-72. 10.1016/0168-8510(96)00822-6.CrossRefPubMed
55.
Alonso J, Prieto L, Anto JM: The spanish version of the SF-36 health survey (the SF-36 health questionnaire): an instrument for measuring clinical results. Med Clin (Barc). 1995, 104 (20): 771-776.
56.
McHorney CA, Ware JE, Raczek AE: The MOS 36-item short-form health survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care. 1993, 31 (3): 247-263. 10.1097/00005650-199303000-00006.CrossRefPubMed
57.
Ortega R, Requejo A, Lopez-Sobaler A: Questionniares for dietetic studies and the assessment of nutritional status. Nutriguía manual of clinical nutrition in primary care. Edited by: Requejo A, Ortega R. 2003, Madrid: Editorial Complutense, 456-459.
58.
Ortega R, Requejo A, Navia B, López-Sobaler A: Recommended daily intakes of energy and nutrients for the spanish population. Food composition A basic tool for assessing nutritional status. Edited by: RM O, López-Sobaler A, Requejo A, Andrés P. 2004, Madrid: Complutense, 82-85.
59.
Chung WK, Power-Kehoe L, Chua M, Chu F, Aronne L, Huma Z, Sothern M, Udall JN, Kahle B, Leibel RL: Exonic and intronic sequence variation in the human leptin receptor gene (LEPR). Diabetes. 1997, 46 (9): 1509-1511.CrossRefPubMed
60.
Clement K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD: Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med. 1995, 333 (6): 352-354. 10.1056/NEJM199508103330605.CrossRefPubMed
61.
Cupeiro R, Benito PJ, Maffulli N, Calderon FJ, Gonzalez-Lamuno D: MCT1 genetic polymorphism influence in high intensity circuit training: a pilot study. J Sci Med Sport. 2010, 13 (5): 526-530. 10.1016/j.jsams.2009.07.004.CrossRefPubMed
62.
Gotoda T, Manning BS, Goldstone AP, Imrie H, Evans AL, Strosberg AD, McKeigue PM, Scott J, Aitman TJ: Leptin receptor gene variation and obesity: lack of association in a white british male population. Hum Mol Genet. 1997, 6 (6): 869-876. 10.1093/hmg/6.6.869.CrossRefPubMed
63.
Hara K, Okada T, Tobe K, Yasuda K, Mori Y, Kadowaki H, Hagura R, Akanuma Y, Kimura S, Ito C, et al: The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun. 2000, 271 (1): 212-216. 10.1006/bbrc.2000.2605.CrossRefPubMed
64.
Hixson JE, Vernier DT: Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res. 1990, 31 (3): 545-548.PubMed
65.
Large V, Hellstrom L, Reynisdottir S, Lonnqvist F, Eriksson P, Lannfelt L, Arner P: Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function. J Clin Invest. 1997, 100 (12): 3005-3013. 10.1172/JCI119854.CrossRefPubMedPubMedCentral
66.
Lindpaintner K, Pfeffer MA, Kreutz R, Stampfer MJ, Grodstein F, LaMotte F, Buring J, Hennekens CH: A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med. 1995, 332 (11): 706-711. 10.1056/NEJM199503163321103.CrossRefPubMed
67.
Matsuoka N, Ogawa Y, Hosoda K, Matsuda J, Masuzaki H, Miyawaki T, Azuma N, Natsui K, Nishimura H, Yoshimasa Y, et al: Human leptin receptor gene in obese japanese subjects: evidence against either obesity-causing mutations or association of sequence variants with obesity. Diabetologia. 1997, 40 (10): 1204-1210. 10.1007/s001250050808.CrossRefPubMed
68.
Taroni F, Verderio E, Fiorucci S, Cavadini P, Finocchiaro G, Uziel G, Lamantea E, Gellera C, DiDonato S: Molecular characterization of inherited carnitine palmitoyltransferase II deficiency. Proc Natl Acad Sci U S A. 1992, 89 (18): 8429-8433. 10.1073/pnas.89.18.8429.CrossRefPubMedPubMedCentral
69.
Ball Geoff D, Crespo Noe C, Cruz Martha L, Goran Michael I, Salem George J, Shaibi Gabriel Q, Weigensberg Marc J: Effects of resistance training on insulin sensitivity in overweight latino adolescent males. Med Sci Sports Exerc. 2006, 38 (7): 1208-1215. 10.1249/01.mss.0000227304.88406.0f.CrossRefPubMed
70.
Benito PJ, Neiva C, Gonzalez-Quijano PS, Cupeiro R, Morencos E, Peinado AB: Validation of the sensewear armband in circuit resistance training with different loads. Eur J Appl Physiol. 2012, 112 (8): 3155-3159. 10.1007/s00421-011-2269-5.CrossRefPubMed
71.
Cupeiro R, González-Lamuño D, Amigo T, Peinado AB, Ruiz JR, Ortega FB, Benito PJ: Influence of the MCT1-T1470A polymorphism (rs1049434) on blood lactate accumulation during different circuit weight trainings in men and women. J Sci Med Sport. 2012, 15 (6): 541-547. 10.1016/j.jsams.2012.03.009.CrossRefPubMed
Metadata
Title
Nutrition and physical activity programs for obesity treatment (PRONAF study): methodological approach of the project
Authors
Augusto G Zapico
Pedro J Benito
Marcela González-Gross
Ana B Peinado
Esther Morencos
Blanca Romero
Miguel A Rojo-Tirado
Rocio Cupeiro
Barbara Szendrei
Javier Butragueño
Maite Bermejo
María Alvarez-Sánchez
Miguel García-Fuentes
Carmen Gómez-Candela
Laura M Bermejo
Ceila Fernandez-Fernandez
Francisco J Calderón
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2012
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-12-1100

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